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Reactive Reports Issue 56 Jeffrey Krise |
A Basic Approach to Chemotherapy Chemists have found a way to attack malignant cells with an anticancer drug, while sparing healthy cells. |
Chemistry World March 28, 2006 Jon Evans |
Explosives go Unleaded Explosives could become safer following the synthesis of lead-free environmentally-friendly primary explosives by researchers in the US. |
Chemistry World March 2, 2015 Andy Extance |
Chemists zinc up 'aromatic' metal cubes Researchers in China and the US have synthesized polyzinc clusters that have pushed back the boundaries of the kind of aromatic structures chemists can make. |
Chemistry World March 10, 2006 |
Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates. |
Chemistry World May 31, 2009 Nina Notman |
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. |
Chemistry World January 19, 2007 Lionel Milgrom |
Quantum Theory Reveals Why Lead Poisons Lead is one heavy metal. It can cause irreversible blood, brain, kidney, and liver damage. But why is it so toxic? Using quantum chemistry and enzyme model compounds, researchers now believe they have the answer. |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World August 2009 Derek Lowe |
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder |
Chemistry World January 3, 2012 Simon Hadlington |
One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division. |
Chemistry World October 2008 Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat' |
Chemistry World April 2009 Derek Lowe |
Column: In the pipeline The author considers the problems of addressing drug development out of sequence |
Chemistry World August 2007 Dylan Stiles |
Opinion: Bench Monkey There is no doubt that many of the world's greatest achievements have been due to complete and utter dumb luck. |
Reactive Reports Issue 62 |
Alumination at last! More powerful solid rocket fuel could be the product of research into a new class of compounds containing aluminum and hydrogen compounds, according to an international research team. |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World January 20, 2010 James Urquhart |
Disilicate synthesis success A compound containing a stable silicon-silicon bond between two negatively charged pentacoordinated silicon atoms - silicates - has been synthesized and isolated for the first time by Japanese researchers. |
Chemistry World May 4, 2011 Emma Shiells |
Anticancer drug found to cause zinc deficiency Cisplatin is responsible for abnormally low zinc levels in patients undergoing chemotherapy, say scientists in China and the UK. |
Food Processing March 2009 Diane Toops |
Kraft Foods Global Thinks Outside the Box with Bioactive Ingredients Kraft hires a pharmaceutical company to help it develop functional foods. |
The Motley Fool March 29, 2007 Brian Lawler |
Genentech Going Forward Genentech gives guidance for first-quarter sales numbers. Investors, take note. |
The Motley Fool May 25, 2007 Brian Orelli |
Amylin Sifts for Gold The biotech mines extra value from its compound library. Investors, take note. |
Chemistry World November 2009 Derek Lowe |
Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times |
Chemistry World September 2007 Derek Lowe |
Column: In the Pipeline Will Phase Zero trials actually help drug development? |
The Motley Fool August 8, 2007 Brian Lawler |
Array's Bright Pipeline Array BioPharma announces its goals for the months ahead in its fourth-quarter results. What is interesting is the varied mix of new compounds in their pipeline. |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. |
Chemistry World December 2008 |
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. |
The Motley Fool June 29, 2007 Brian Lawler |
Genentech's All Good The biotech's latest partnership deal is nothing to worry about. Investors, take note. |
Chemistry World June 2011 |
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most. |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery |
Chemistry World June 18, 2015 Emma Stoye |
Crowdsourcing compounds to tackle antibiotic resistance Chemists around the world are being called on to donate samples of novel compounds they have synthesized to a crowdsourcing project that aims to find new antibiotics. |
Bio-IT World February 10, 2003 Malorye Branca |
Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic. |
Bio-IT World August 18, 2004 Kevin Davies |
In Praise of Chemical Diversity How to build better small-molecule libraries. |
Chemistry World April 2011 |
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products. |
Chemistry World October 28, 2014 Derek Lowe |
Chemical space is big. Really big. We are not going to run out of interesting and useful structures, and the uses that they could be put to are probably also beyond our imagining. In chemical space, we really do have an effectively endless frontier. |
Reactive Reports Issue 41 David Bradley |
Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip. |
Chemistry World July 2008 Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril |
Chemistry World November 27, 2013 Derek Lowe |
Rolling boulders uphill A lot of preclinical projects don't even get off the ground, and many that do still never deliver anything to the development groups. |
Chemistry World March 2006 |
Letters Chemistry's changing face... Exeter's chemistry closure... DDT ditty... Chlorine in poetry... etc. |
Chemistry World November 4, 2015 Suzanne Howson |
Oral delivery of anticancer drug Scientists in China have unveiled a way to deliver a platinum-based anticancer drug orally. |
Chemistry World July 2009 Derek Lowe |
Column: In the pipeline The author wonders where we'd be without the formulation chemists |
Chemistry World February 22, 2011 Amaya Camara-Campos |
Repairing faulty genes Israeli scientists have developed compounds that could be better treatments for genetic diseases than current drugs. |
Science News May 3, 2003 Janet Raloff |
Selenium's Value to Prostate Health Prostate cancer remains the most common malignancy among U.S. men. Though few studies have offered much insight into what triggers this disease, a growing number of researchers have found evidence suggesting that dietary selenium protects men against this cancer. |