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Chemistry World March 25, 2011 Simon Hadlington	New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.
Chemistry World February 6, 2008 Simon Hadlington	Better Detection of DNA Synthesis Researchers in the US have developed a new way to detect DNA synthesis in living cells by using click chemistry -- the concept of reacting together two 'high energy' molecules that 'click' together efficiently under mild conditions.
Chemistry World April 12, 2012 Simon Hadlington	Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds.
Chemistry World October 29, 2009 Lewis Brindley	Cascading reactions in artificial cells Dutch researchers have started performing multi-step reactions inside artificial cells made from enzymes and polymers.
Bio-IT World February 10, 2003 Malorye Branca	Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic.
Chemistry World January 17, 2010 Simon Hadlington	Sugars synthesised with help of promiscuous enzyme European researchers have discovered a new way to make synthetically elusive sugar molecules that could lead to novel vaccine candidates and other medically important compounds.
Reactive Reports Issue 56 Jeffrey Krise	A Basic Approach to Chemotherapy Chemists have found a way to attack malignant cells with an anticancer drug, while sparing healthy cells.
Chemistry World February 24, 2011 Laura Howes	Seaweed recruited in fight against malaria Compounds found in seaweed have shown anti-malarial properties, killing even drug-resistant malaria parasites.
Chemistry World May 15, 2014 Jenifer Mizen	Freeze-dried cells make better biocatalysts A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses.
Chemistry World January 20, 2014 David Bradley	Molecular librarians create druglike collections Finding biologically active small molecules with pharmaceutical potential is a bittersweet process. Now, a new approach to building libraries of diverse alkaloid-type structures has been developed by US chemists.
Chemistry World September 29, 2015	Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make?
Chemistry World November 27, 2008 Lewis Brindley	Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.
Chemistry World January 4, 2007 Henry Nicholls	Microscopic Lab Investigates Contents of a Cell It's small-scale science that could have a massive impact on research into cell biology. Scientists have produced a microscopic laboratory where they can count individual proteins in a single cell.
Chemistry World February 28, 2013 Andy Extance	Chemical transport defines 'Goldilocks' cell size A US team has suggested molecular movement as an answer to the question of why cells are the size they are. A question that they say 'still awaits an answer from first principles'.
Chemistry World July 2, 2007 Michael Gross	Transistor tuned to ion channel As living cells can detect many compounds with high sensitivity via receptors on their membranes, researchers are keen to exploit them in electronic biosensors. Researchers in Germany now report the feasibility of just such a receptor-cell-transistor biosensor.
Chemistry World October 14, 2008 Simon Hadlington	Enzymes hit with double punch US chemists have made a small molecule that simultaneously blocks two key enzymes involved in the growth of cancer cells.
Chemistry World January 18, 2009 Hayley Birch	Plants reprogrammed to produce potential drugs Plants could one day function as factories for producing anti-cancer drugs, say US scientists.
Chemistry World July 28, 2009 Michael Gross	DNA to direct and switch off chemo Researchers in the US have developed a new approach to cancer chemotherapy using short DNA strands to help target delivery of the drug directly to cancer cells, and 'call it off' should problems arise.
Chemistry World February 12, 2014 Manisha Lalloo	Synthetic strategy targets 'undruggable' small RNAs Chemists in the US have found a way to predict small molecules that can target short pieces of RNA involved in some diseases, such as cancer.
Chemistry World November 1, 2013 Megan Tyler	High-throughput chip for drug screening in 3D A simple micro-array chip developed by scientists in China could sharpen the search for new drugs by enabling the high-throughput screening of drug candidates against cells cultured in three dimensions.
Chemistry World November 24, 2011 Elinor Richards	Blocking cancer's path A concise synthesis of the natural product rasfonin could reignite interest in this molecule as a tool to develop cancer drugs, say scientists from the Netherlands.
Chemistry World July 14, 2011 Simon Hadlington	Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.
Bio-IT World December 15, 2003 Malorye A. Branca	Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful.
Chemistry World May 20, 2015 Katrina Kramer	Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs.
Chemistry World July 2008 Kevin Rogers	What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril
Chemistry World August 2, 2011 Kate McAlpine	Hacking into chemical cell phone calls US researchers have made a nanodevice that can eavesdrop on a cell's mutterings, and they say it could be adapted to listen in on conversations between cells.
Chemistry World August 1, 2013 James Urquhart	Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.
Chemistry World August 16, 2009 Tom Bond	Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.
Chemistry World December 12, 2013 Jeanne Therese Andres	Kiss-and-run drug delivery Carriers that release hydrophobic substances at cell membranes but do not enter the cells themselves could be the foundation for a new way to deliver drugs into cells, according to a team of scientists in Germany.
Chemistry World August 15, 2007 John Bonner	Chemists Claim Biological Alchemy South Korean chemists say they have turned muscle cells from the sole of a human foot into something akin to stem cells, using a simple molecule called neurodazine.
Chemistry World February 15, 2006 Simon Hadlington	Pharmaceutical Promise in the Desert Two molecules that inhibit a protein linked to cancer pathogenesis have been discovered in the Arizona desert.
Chemistry World June 9, 2008 Simon Hadlington	Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes.
Chemistry World December 6, 2013 Julianne Wyrick	Crowdsourcing unearths promising anticancer compound Crowdsourcing soil from across the US turned up some interesting fungi with promising medicinal molecules.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World September 26, 2006 Fiona Case	Synchronised Delivery for DNA and Drugs Polymer capsules that can simultaneously deliver drug molecules and DNA into a cell could boost the power of cancer treatments.
Chemistry World April 23, 2010 Lewis Brindley	Ricin antidote on the horizon For the first time, compounds that protect against ricin poisoning have been identified by French researchers.
Chemistry World August 2009 Derek Lowe	Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder
Chemistry World August 30, 2009 Phillip Broadwith	C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.
Chemistry World May 31, 2009 Nina Notman	The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used.
Chemistry World May 27, 2008 Simon Hadlington	Computer brain unearths better insect repellents Mosquitoes seeking to gorge on human blood could soon be faced with a new range of chemicals designed to put them off, thanks to new research.
Chemistry World April 2011	Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products.
Chemistry World August 21, 2008 Fred Campbell	Double bonding with silicon In a landmark for silicon chemistry, US researchers have reported the first stable silicon (0) compound to contain a silicon-silicon double bond.
Chemistry World June 15, 2007 Lionel Milgrom	Electrochemical Screening for Anti-Cancer Drugs A test that predicts an individual cancer patient's response to different drugs is about to enter clinical trials, developers have announced. The chances of successful treatment will increase, they predict, while costs will decrease.
Reactive Reports Issue 41 David Bradley	Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip.
Chemistry World November 2009 Derek Lowe	Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times
HHMI Bulletin May 2010 Sarah C.P. Williams	Lab-Grown Liver New cell culture system solves problem of growing liver cells.
Chemistry World November 2007 Dylan Stiles	Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.
Chemistry World January 2012	Column: In the pipeline Derek Lowe discusses how companies are increasingly trying to do more with the compounds they already know a lot about
Chemistry World October 28, 2014 Derek Lowe	Chemical space is big. Really big. We are not going to run out of interesting and useful structures, and the uses that they could be put to are probably also beyond our imagining. In chemical space, we really do have an effectively endless frontier.
Chemistry World March 10, 2006	Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates.