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Chemistry World May 20, 2015 Katrina Kramer	Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs.
Chemistry World May 31, 2009 Nina Notman	The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used.
Chemistry World September 29, 2015	Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make?
Bio-IT World November 19, 2004 Kevin Davies	De-Lovely Pharmaceuticals De Novo Pharmaceuticals identifies novel compounds right before your eyes.
Chemistry World June 2008 Sarah Houlton	Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success
Chemistry World October 2008 Derek Lowe	Column: In the pipeline The author seeks a cure for 'compound bloat'
Chemistry World March 2012	Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug
Wired Erin Biba	Molecular Frameworks, the Building Blocks of All Life The world is complicated, but not as complicated as you might think. Most organic molecules derive from a few relatively simple architectures.
Chemistry World July 14, 2011 Simon Hadlington	Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.
Chemistry World January 3, 2012 Simon Hadlington	One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division.
Chemistry World November 28, 2013	Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity.
Bio-IT World August 18, 2004 Kevin Davies	In Praise of Chemical Diversity How to build better small-molecule libraries.
Chemistry World November 30, 2007 Lewis Brindley	Crystal Clear Structure Prediction One team of researchers has hit the jackpot by correctly predicting the crystal structures of four organic molecules in a competition organized by the University of Cambridge.
Chemistry World April 2011	Molecular Obesity is Weighing Down Drug Discovery Medicinal chemistry's quest for potent drug candidates has resulted in molecules that are too large and too lipophilic for their own good.
Chemistry World November 2011 Derek Lowe	Column: In the Pipeline In recent years there's another class of 'unknown' compounds that's become more prominent than ever: the ones you can buy from the chemical catalogues.
Chemistry World February 21, 2007 Tom Westgate	Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World August 2007 Derek Lowe	Opinion: In the Pipeline Process chemists just don't get the credit they deserve.
Chemistry World October 2010	Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery
Chemistry World November 30, 2012 Andy Extance	Chemists cull compounds using 'intuition' Medicinal chemists might be using far fewer parameters to choose candidate fragments for a screening collection than they think they do. Their choices can be mimicked based on just one or two properties, a team led by researchers at Swiss-headquarted pharmaceutical firm Novartis has found.
Information Today November 13, 2006 Ed Vawter	Thomson Pharma Adds 2.2 Million Chemical Structures to PubChem Database While it is exciting to see content from a major information source such as Thomson Pharma get incorporated into a freely available government-sponsored database such as PubChem, there are still drawbacks.
Chemistry World August 2009 Derek Lowe	Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder
Chemistry World September 24, 2009 Phillip Broadwith	Carbon can't but tin can US chemists have discovered that distannynes - tin-based analogues of acetylenes - can react reversibly with ethene to make cyclic complexes.
The Motley Fool May 25, 2007 Brian Orelli	Amylin Sifts for Gold The biotech mines extra value from its compound library. Investors, take note.
Chemistry World May 27, 2008 Simon Hadlington	Computer brain unearths better insect repellents Mosquitoes seeking to gorge on human blood could soon be faced with a new range of chemicals designed to put them off, thanks to new research.
Chemistry World December 10, 2013 David Bradley	Breaking the mold with recycled plastic drugs James Hedrick of the IBM Almaden Research Center, US, and colleagues have used supramolecular chemistry to self-assemble a range of polymer-like structures that display antifungal properties.
Chemistry World September 12, 2008 Rebecca Trager	NIH funds chemical biology network NIH-funded scientists will have access to the tools for rapidly screening hundreds of thousands of small molecules against many novel biological assays at lower costs than previously possible,' said the agency's director, Elias Zerhouni.
Chemistry World October 28, 2014 Derek Lowe	Chemical space is big. Really big. We are not going to run out of interesting and useful structures, and the uses that they could be put to are probably also beyond our imagining. In chemical space, we really do have an effectively endless frontier.
Chemistry World November 2, 2015	Batzelladine B Of all the diverse substances that nature produces, the alkaloids -- small molecules containing basic nitrogen -- have had the greatest impact on human history and health.
Food Processing March 2009 Diane Toops	Kraft Foods Global Thinks Outside the Box with Bioactive Ingredients Kraft hires a pharmaceutical company to help it develop functional foods.
Chemistry World July 2008 Kevin Rogers	What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril
Chemistry World December 10, 2014	Big pharma opens up abandoned drugs Sixty eight stalled pharmaceutical compounds are being made available for academic research through the UK Medical Research Council.
Chemistry World November 2007 Dylan Stiles	Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.
Chemistry World November 26, 2015 Rebecca Trager	Drug firms to share chemical compound libraries Anglo-Swedish pharmaceutical firm AstraZeneca and French drug company Sanofi have agreed to exchange 210,000 chemical compounds from their respective proprietary libraries.
Chemistry World April 26, 2007 Richard Van Noorden	Hydrogen Busters go Synthetic Chemists have created a small molecule which mimics the way natural enzymes chew up hydrogen. The model should inspire designs for new catalysts that can break up hydrogen in fuel cells; or (running in reverse) help produce the fuel for a hydrogen economy.
Chemistry World January 18, 2009 Hayley Birch	Plants reprogrammed to produce potential drugs Plants could one day function as factories for producing anti-cancer drugs, say US scientists.
Chemistry World March 5, 2015 Emma Stoye	Forgotten synthetic PhD theses set to be given new lease of life A team of researchers have amassed a digital collection of more than 75,000 compounds from PhD theses that might otherwise have mouldered in obscurity.
Chemistry World July 26, 2012 Derek Lowe	Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time.
Chemistry World August 1, 2013 James Urquhart	Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.
Chemistry World July 3, 2014 Tami Spector	Of atoms and aesthetics Molecular aesthetics means many things to a few people. For some it means tangible aspects of compounds; for others yet, the ways that chemists represent molecules.
Chemistry World April 2011	Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products.
Chemistry World August 2008	Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?
Chemistry World December 2008	Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project.
Bio-IT World February 10, 2003 Malorye Branca	Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic.
Chemistry World February 27, 2009 Hayley Birch	More data from mixtures via NMR Finnish scientists have developed a new technique for separating out the NMR spectra of compounds in a mixture.
Chemistry World November 24, 2006 Richard Van Noorden	Cooking up Nano-Fusilli Here's a new twist on nanotubes: chemists have found a set of organic molecules that spontaneously assemble themselves into a helical spiral with a hollow core.
Chemistry World April 2007 Derek Lowe	Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?
Chemistry World February 8, 2006 Jon Evans	To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space.
Chemistry World March 12, 2015 Matthew Gunther	Chemical building blocks produce a wellspring of organic molecules Scientists in the US have developed an automated platform to create small organic molecules from a set of simple of chemical building blocks.
Chemistry World July 6, 2006 Michael Gross	Insecticide Simplified A rapid, flexible way to make variants of potent insecticide molecules known as spinosyns could help to combat the growing problem of insect resistance, according to German chemists.