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Chemistry World February 2, 2012 Philip Robinson |
Ultrafast NMR shows the way Chemists have created an ultrafast NMR technique that can 'watch' how chemical reactions occur in real time. They've used the technique to follow the formation of pyrimidines from carbonyls and even identified new intermediates never before thought to be part of the reaction. |
Chemistry World June 24, 2011 Yuandi Li |
An NMR machine in a fume hood Scientists in Germany have demonstrated a portable nuclear magnetic resonance spectrometer that's small enough to be placed in a fume cupboard to monitor the progress of a reaction in situ. |
Chemistry World May 24, 2013 David Bradley |
Microwaves show their hand The chirality of a gas phase molecule held in an electric field can be revealed using microwave spectroscopy. Hooking the technique to a separation step might even be exploited to isolate a specific enantiomer from a racemic mixture of both forms. |
Chemistry World October 15, 2012 Melissae Fellet |
Synthesis by mass spectrometry Chemists have used mass spectrometry, commonly used to analyze molecules, to synthesize them on the microscale. |
Chemistry World October 26, 2007 Richard Van Noorden |
Proton NMR Spots Shape-Shifting Tablets UK scientists have extended the bounds of solid-state NMR to quickly solve a problem plaguing the pharmaceutical industry: how to spot unwanted crystal packing forms in a drug tablet. |
Chemistry World February 15, 2011 Mary Badcock |
Building up a natural product toolkit US scientists have come up with a method that makes it easier to extract compounds that are difficult to isolate from crude natural product mixtures. |
Chemistry World April 11, 2012 Andy Benniston |
Identifying unknowns As a person who has taught undergraduate students the basics of how to identify unknown organic compounds using spectra I looked forward to reading Interpretation of Organic Spectra by Yong-Cheng Ning. |
Reactive Reports Issue 52 David Bradley |
Interview with Gary Martin With more than 35 years experience in NMR spectroscopy, Gary Martin reveals some of the insights he has gained in this field. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World January 20, 2011 Jon Cartwright |
Chemists separate water isomers Chemists in Israel claim to have separated water into its two spin isomers and suggest the outcome could deliver highly sensitive nuclear magnetic resonance experiments. |
Chemistry World June 14, 2011 |
A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR. |
Chemistry World November 25, 2014 Hugh Cowley |
Benchtop NMR gives feedback in flow The platform performs algorithm driven organic synthesis using real-time feedback from in-line flow NMR spectroscopy |
Chemistry World May 3, 2013 Alison Rodger |
VCD spectroscopy for organic chemists I highly recommend VCD Spectroscopy, by Philip Stephens and others, for organic chemists as the textbook of choice on this useful topic. |
Chemistry World June 10, 2010 Simon Hadlington |
Elusive intermediate snared Chemists in Germany have succeeded in trapping an elusive intermediate involved in a key synthetic reaction catalysed by an organic molecule. |
Chemistry World November 13, 2012 Phillip Broadwith |
Calculations correct natural product structure US chemists have used NMR prediction calculations to correct the structure of a complex natural product, aquatolide. The work emphasises the power of this burgeoning technique to challenge and inform experimental structure determination. |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World March 21, 2007 Richard Van Noorden |
Forcing a Reaction US chemists have forced molecules to react by ripping their bonds apart with ultrasound. The scientists carefully stretched one targeted bond until it snapped, guiding the molecule's subsequent reaction into pathways forbidden by conventional chemistry. |
Chemistry World July 2007 Dylan Stiles |
Opinion: Bench Monkey Synthesizing molecules that force atoms into bizarre contortionist acts is the only way to learn. |
Chemistry World August 23, 2010 Lewis Brindley |
Microscopic barcodes with extra stirring A way to label molecules with colourful barcodes has been developed by chemists in South Korea. |
Chemistry World March 10, 2006 |
Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates. |
Chemistry World February 24, 2014 Derek Lowe |
Tools of the trade Organic synthesis has always depended on instrumental analysis, even when the instruments were a thermometer for distillations and a melting point stage for crystals. |
Chemistry World July 30, 2013 Derek Lowe |
Knowledge lost or time gained? Techniques like infrared spectroscopy are falling from favor. |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. |
Chemistry World March 2008 Derek Lowe |
Column: In the Pipeline How to revive some lost chemistry techniques. |
Bio-IT World May 2006 Robert M. Frederickson |
A New (Bio)Spin on NMR Applications Bruker BioSpin recently announced several introductions to improve throughput, sensitivity, and versatility of its systems for nuclear magnetic resonance applications starting with the SampleJet, a robotics system for high-throughput transfers of NMR sample tubes into the NMR spectrometer. |
Chemistry World January 30, 2013 Philip Robinson |
NMR with a light touch Interactions between NMR-active nuclei in a sample and laser light could lead to a new, simpler form of NMR. |
Chemistry World August 30, 2006 Tom Westgate |
Lasers Shed Light on Magnetic Resonance A new way of measuring nuclear magnetic resonance (NMR) in liquid samples could have implications across spectroscopy and imaging, report researchers. |
Chemistry World September 28, 2010 Lewis Brindley |
Helium nanodroplets host ion analysis Chemists have developed a sensitive new infrared spectroscopy method that analyses molecular ions by capturing them in nanosized bubbles of freezing helium. |
Reactive Reports Issue 75 David Bradley |
CSI: Waco A statistical method that processes spectroscopic measurements very quickly could allow crime scene investigators to determine time of death of skeletal remains more accurately and quicker than before. |
Chemistry World June 12, 2013 Kirsty Muirhead |
An end to chasing molecules that were never there? Ariel Sarotti from the Rosario National University, Argentina, has developed a new, computationally inexpensive method combining calculated and experimental 13C NMR data to flag up incorrect structures. |
Chemistry World March 2007 Dylan Stiles |
Opinion: Bench Monkey For structural analysis of small molecules, NMR spectroscopy can't be beat. |
Chemistry World September 1, 2011 Yuandi Li |
Self-cleaning fabrics now even cleaner US scientists have made a self-cleaning fabric that lasts longer, shows better antibacterial action and is more comfortable to wear than current materials. |
Chemistry World July 26, 2012 Cecilia Fenech |
Understanding 2D NMR Organic structure determination using 2-D NMR spectroscopy: a problem-based approach by Jeffrey Simpson is a balanced text covering both theoretical and practical aspects of NMR spectroscopy. |
Chemistry World November 18, 2014 Katrina Kramer |
Molecules: the elements and the architecture of everything Molecules is a serious attempt to explain the world of chemical compounds to the reader without assuming previous science knowledge. |
Chemistry World October 16, 2006 Michael Gross |
Brief Encounter Observing fleeting interactions between molecules in solution requires extremely sophisticated methods. NMR spectroscopists have now developed tools that let them watch the transient encounter between two proteins before a well-defined complex is formed. |
Chemistry World October 23, 2013 Manisha Lalloo |
NMR thermometer takes reactor's temperature Scientists in the US have used NMR to create temperature maps of reactions taking place inside catalytic reactors. Their technique opens the door to an easy, non-invasive way to discover hot and cold 'spots' inside reactors. |
Chemistry World January 9, 2014 |
Spinning into focus NMR is used by big industry, and scientists in pharmaceutical companies, for example, have appreciated the benefits of NMR spectroscopy for years. It reveals the structure of molecules in a sample, providing more information than some other analytical techniques. |
Chemistry World May 17, 2012 David Bradley |
Plutonium in a Spin Spectroscopists have finally pinned down the nuclear magnetic resonance spectrum of plutonium-239. The finding might point the way to improved approaches to the long-term storage of nuclear waste. |
Chemistry World January 20, 2014 David Bradley |
Molecular librarians create druglike collections Finding biologically active small molecules with pharmaceutical potential is a bittersweet process. Now, a new approach to building libraries of diverse alkaloid-type structures has been developed by US chemists. |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World August 13, 2015 Heather Powell |
Study probes role of chemical corruption in origin of life Researchers are incorporating what they describe as defective compounds into their experiments to help them understand how the first molecules of life formed. |
Chemistry World December 12, 2013 Emma Stoye |
Cutting edge chemistry in 2013 What discoveries caused the biggest buzz in chemistry labs in 2013? |
Chemistry World October 26, 2011 Jon Cartwright |
Complex organic matter may have been found beyond the Solar System Scientists in Hong Kong believe they have found traces of organic compounds deep in interstellar space that have similar structures to coal and oil. |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Reactive Reports December 2006 David Bradley |
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database. |
Chemistry World May 30, 2014 Phillip Broadwith |
How good do you want it? In a chemical manufacturing environment, the most important questions for process chemists are qualitative: how shall we make this molecule? How can we do it safely? |
Chemistry World May 31, 2009 Nina Notman |
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. |
Reactive Reports Issue 62 |
Alumination at last! More powerful solid rocket fuel could be the product of research into a new class of compounds containing aluminum and hydrogen compounds, according to an international research team. |
Chemistry World March 10, 2011 Kate McAlpine |
Aerosol data from BP spill Analysis of atmospheric data suggests that emissions of intermediate volatile organic compounds and semi-volatile organic compounds were low compared with those of volatile organic compounds. |
Chemistry World March 6, 2013 Michal Leskes |
Solid state NMR: basic principles & practice This book by Apperley et al., first considers different types of solids and their properties, followed by a detailed survey of the main NMR interactions and phenomena that govern the spectra. |