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Chemistry World May 2010 Derek Lowe |
Column: In the pipeline The author wonders whether tagging molecules with fluorescent labels for assay is like tracking the members of a shoal of fish by tying each one to a whale. In the pharmaceutical business, our work absolutely lives and dies by assay results. |
Chemistry World June 27, 2010 Simon Hadlington |
Nanoparticles allow remote control of cells In an experiment reminiscent of the mind-control rays that featured prominently in B-movies from the 1950s, scientists in the US have used a magnetic field to alter the behavior of an animal. |
Technology Research News July 13, 2005 |
Magnetics Drives Particle Patterns Researchers have devised a way to use electric and magnetic fields to assemble magnetic microparticles into a wide variety of patterns, including clusters, rings, chains and networks. |
Chemistry World February 27, 2009 Hayley Birch |
More data from mixtures via NMR Finnish scientists have developed a new technique for separating out the NMR spectra of compounds in a mixture. |
Chemistry World July 13, 2007 Tom Westgate |
Colourful Colloids A simple mixture of iron oxide, a polymer and water can take on any color simply by applying a magnetic field. |
Chemistry World February 18, 2009 Lewis Brindley |
Nanomaterials Blossom US researchers have found a new way to use magnetic fields to encourage nanoparticles to self-assemble into unique shapes. |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. |
Chemistry World August 3, 2010 Lewis Brindley |
Nanoparticles and ultrasound team up to treat tumors A new, non-invasive method to deliver drugs to the brain has been developed by Taiwanese researchers. |
Technology Research News January 14, 2004 Eric Smalley |
Nanoparticle dyes boost storage The idea of storing data in fluorescent dyes has been around for a while, and researchers have been trying to boost storage capacity by recording multiple bits of information in a single spot using several types of dye. A new solution to this problem uses layered nanoparticles. |
Chemistry World May 13, 2009 Lewis Brindley |
Combination nanoparticles to fight cancer Korean chemists have assembled a multitalented nanoparticle that can hunt down, treat, and illuminate cancerous cells. |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery |
Chemistry World June 19, 2009 Jon Cartwright |
Nanoparticles make 'self-erasing' images Materials displaying 'self-erasing' color images have been created by chemists in the US, who have studied how certain nanoparticles can assemble and disassemble themselves under different wavelengths of light. |
Chemistry World May 31, 2009 Nina Notman |
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. |
Chemistry World April 30, 2008 Lewis Brindley |
Chemical compass clue to migration mystery Trying to identify the mysterious innate compass that many animals use to navigate the globe, chemists at the University of Oxford, UK, have shown for the first time that the Earth's magnetic field can influence the outcome of a chemical reaction. |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. |
Chemistry World June 15, 2010 Manisha Lalloo |
Colour change test for brain chemicals Chemists in China have devised a system which uses gold nanoparticles to detect glucose in the brain, based on a simple colour change test. |
Chemistry World July 21, 2015 Tim Wogan |
Nanoparticle cats drawn at the flick of a switch A new way of using light to reversibly assemble nanoparticles has been developed by scientists in Israel. |
Chemistry World December 2008 |
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. |
Chemistry World October 15, 2009 Simon Hadlington |
Optical conveyor belt gathers up molecules Researchers in Germany have developed a novel way to 'round up' biological molecules that are freely suspended in solution and trap them in a confined space using nothing more than light. |
Chemistry World October 22, 2013 Simon Hadlington |
Virtual molds cast colloid Blue Mosque A way to direct colloids to self-assemble in an almost infinite variety of configurations has been devised. The technique relies on the creation of a pre-determined pattern of magnetic fields to generate a 'virtual mold' to dictate the final position of the particles. |
Chemistry World June 2008 |
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team. |
Chemistry World February 4, 2011 |
MOF magnets deliver drugs German scientists have encapsulated nanomagnets inside metal organic frameworks. The MOF magnets can be filled with a drug, which is released when a magnetic field is applied. |
Chemistry World January 14, 2009 Hayley Birch |
MRI at the nanoscale US scientists have demonstrated the remarkable power of magnetic resonance imaging (MRI) by adapting it to create 3D nanoscale pictures of a tobacco mosaic virus. |
Technology Research News December 11, 2002 Eric Smalley |
Microscopic mix strengthens magnet Magnets are usually an either-or proposition. They either generate a strong magnetic field or they hold up well in the presence of external magnetic fields. A method that mixes the two types of magnets at the nanoscale could pave the way for smaller electric motors and generators. |
Bio-IT World October 14, 2004 Robert M. Frederickson |
Nanosphere Strikes Gold Recently, scientists at Nanosphere developed a colorimetric method for DNA detection that obviates the need for target or signal amplification. |
Chemistry World November 6, 2009 Phillip Broadwith |
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World November 21, 2012 James Urquhart |
Two-faced particles self-assemble in sync US scientists have synchronized the motion of colloidal magnetic spheres with a rotating magnetic field and found that the particles self-organize into micrometer-sized tubes. |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Chemistry World July 25, 2013 Rowan Frame |
Nanomagnets clean blood Nanoparticles that never have to enter the body can capture harmful components in blood, scientists in Switzerland have shown. |
Chemistry World October 13, 2011 Rachel Cooper |
Beating the Counterfeiters Scientists from China have created nanoparticles with dual mode color for anti-counterfeiting ink, making it harder to imitate than current inks. |
Chemistry World July 31, 2008 |
Nanostructures Made Easy Scotland-based chemists have invented a new way to build nanoscale arrays of molecules over a large surface area: a technique that may be key to making nanostructures in sophisticated sensors, catalysts, and tiny computer parts. |
Chemistry World March 29, 2012 Simon Hadlington |
Seeds of life incubated in proto-planetary nurseries New findings imply that the organic chemistry required to produce the necessary molecules for life is part of the normal processes of planet formation. |
Chemistry World October 30, 2014 Emma Stoye |
DNA 'barcodes' used to track food A DNA 'barcode' that can be added directly to food to enable it to be tracked and authenticated as it moves from farm to fork has been developed by scientists in Switzerland. |
Chemistry World July 13, 2010 Lewis Brindley |
Magnetic micro-machines made from liquid iron Chinese researchers have made microscopic springs and turbines by shining light through ferrofluids - liquids containing iron nanoparticles. |
Chemistry World May 17, 2012 Rebecca Brodie |
Enhancing Fingerprints with Electrochromism Scientists have developed a method to enhance latent fingerprints on metal surfaces using electrochromism, a process that causes a color change when a charge is applied. |
Chemistry World November 28, 2007 Tom Westgate |
Molecular Traffic Spied in Nanoscale Tube Network Chemists in Germany have tracked single molecules diffusing through a porous solid for the first time. |
Chemistry World May 1, 2012 David Bradley |
A colorful way to size up nanoparticles Researchers in China have now developed a straightforward light-scattering technique to estimate the size of gold nanoparticles in the 35 to 110nm range. |
Chemistry World April 1, 2008 Lewis Brindley |
Easier Cancer Imaging with Raman A new imaging technique based on Raman spectroscopy has been used to illuminate tumors in mice with unprecedented precision. |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Reactive Reports December 2003 David Bradley |
Mo' Better Blues Vesicles form from molybdenum wheels, giving rise to deep blue water. |
Chemistry World March 20, 2009 Jon Cartwright |
Medical Probes Get Easy to Spot Scientists in the US have created nano-scale medical probes that are visible via both magnetic resonance imaging (MRI) and optical microscopy. |
Chemistry World July 20, 2012 Simon Hadlington |
New type of chemical bond around dwarf stars The work, led by Trygve Helgaker at the University of Oslo in Norway, not only provides insights into fundamental aspects of electronic interactions with magnetic fields, but also sheds light on the exotic chemistry that exists in stellar environments. |
Reactive Reports Issue 60 David Bradley |
Fried Rust Could Prevent Arsenic Poisoning Arsenic-contaminated drinking water, could one day become a thing of the past thanks to the unexpected discovery of the magnetic properties of rusty nanoparticles. |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug |
Chemistry World November 2008 Derek Lowe |
Column: In the pipeline Drug discovery chemists live by assay data; we depend on these numbers to tell us if we're heading in the right direction with our molecules. |
Chemistry World October 2008 Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat' |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions |
Chemistry World September 2, 2007 Lewis Brindley |
Nanoparticles Paint a Finer Picture Swiss scientists have developed a process that can print detailed images using nanoparticles as 'ink', while maintaining their catalytic and optical properties. |