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HHMI Bulletin
Nov 2011
Sarah C. P. Williams
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. mark for My Articles similar articles
Bio-IT World
April 15, 2003
Mark D. Uehling
Target Elimination Industry and FDA scientists turn to databases, applications software, and laboratory chips to move the safest, most effective molecules into clinical trials. mark for My Articles similar articles
Bio-IT World
September 11, 2003
Malorye Branca
The Odd Couple CombinatoRx brings matchmaking to drug discovery and development. mark for My Articles similar articles
Bio-IT World
May 19, 2004
John Russell
Informatics Black Boxes ... Not! Vertex's chief technical officer, discusses informatics' bad reputation, buying vs. building, open-source tools, and ROI on IT. mark for My Articles similar articles
Chemistry World Fishing for Chemical Answers to Biological Questions James K. Chen talks about chemical biology, his love for the outdoors and fly fishing. mark for My Articles similar articles
Bio-IT World
December 15, 2003
Malorye A. Branca
Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful. mark for My Articles similar articles
Pharmaceutical Executive
February 1, 2006
Ron Feemster
Gene Logic: Rescue Squad One or two late-stage clinical failures can land promising drug candidates on the shelf. Forever? Maybe not. Gene Logic tests Big Pharma's dead drugs for hundreds of different targets. mark for My Articles similar articles
Bio-IT World
September 2006
Kevin Davies
Pfizer's Global Survey of Pharmacological Space The pharma blends knowledge, computational chemistry and research informatics to build a unified database. Gathering all the data in one place offered greater control for indexing and data retrieval and management, enabling Pfizer scientists to perform global mapping. mark for My Articles similar articles
Bio-IT World
April 16, 2004
Malorye Branca
Finding the Perfect Fit Fragment-based drug discovery is unique and effective. mark for My Articles similar articles
Bio-IT World
January 21, 2005
Defining 'Integrative Genomics' Five experts from academia and industry discuss the burgeoning field of integrative genomics. mark for My Articles similar articles
CIO
October 15, 2001
Stephanie Overby
Drug Companies on speed The marriage of IT and medical research may be just what traditional pharmaceutical companies need to survive in an increasingly competitive field. Learn how IT is bringing the pharmaceutical industry into the information age... mark for My Articles similar articles
Bio-IT World
November 12, 2002
James Golden
The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success. mark for My Articles similar articles
Bio-IT World
July 11, 2002
Malorye Branca
Deep Sequence Diving Like sailors of old, genomic data miners dream of discovering riches and fame. Given the recent improvements in analytics -- and a little more time -- they just might succeed. mark for My Articles similar articles
Chemistry World
August 13, 2015
Exploiting the data mine Chemists must embrace open data to allow us to collectively get the best out of the masses of new knowledge we unearth, reports Clare Sansom mark for My Articles similar articles
Chemistry World
May 31, 2009
Nina Notman
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. mark for My Articles similar articles
Wired
August 2003
Jennifer Kahn
The End of Cancer (As we Know it) Diagnosis. Chemotherapy. Radiation. Slow painful death. No more. A new era of cancer treatment is dawning. Meet three scientists who are using the revelations of the Human Genome Project to reshape medicine. mark for My Articles similar articles
Bio-IT World
August 18, 2004
Kevin Davies
In Praise of Chemical Diversity How to build better small-molecule libraries. mark for My Articles similar articles
Bio-IT World
March 2007
Kevin Davies
Leading by Example At Cambridge Healthtech Institute's annual Pharmaceutical and Biotech Leader's Summit, drug industry executives provided accounts of the profound organizational and technological changes that are helping organizations overcome industry-wide challenges. mark for My Articles similar articles
Chemistry World
June 23, 2015
Derek Lowe
Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example. mark for My Articles similar articles
Bio-IT World
September 2005
John Russell
BioSeek's MAP to Discovery Now, after roughly five years of platform development and building a database of assays, BioSeek seems poised for growth. mark for My Articles similar articles
Bio-IT World
August 13, 2003
Malorye Branca
Targeting Tumors Next-generation cancer drugs will take aim with unprecedented certainty, but making them requires a new discovery and development paradigm. mark for My Articles similar articles
Chemistry World
September 29, 2015
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make? mark for My Articles similar articles
Bio-IT World
December 10, 2002
Hillel Alpert
Bio-IT Shines Bright in Israel Companies such as Quark and Pharmos are still flourishing as other industries decline in this country torn by conflict. mark for My Articles similar articles
Chemistry World
July 2010
Column: In the pipeline Derek Lowe ponders the possibility of phosphatase inhibitors mark for My Articles similar articles
Bio-IT World
November 14, 2003
Malorye Branca
Genomics Provides the Kick Inside New tools and business structures show signs of plumping early-stage pipelines. mark for My Articles similar articles
Bio-IT World
March 10, 2003
Mark D. Uehling
Technology Overload Inundated with new IT tools and mountains of data, the pharmaceutical industry struggles to pull it all together. mark for My Articles similar articles
Bio-IT World
April 16, 2004
Kevin Davies
The Matrix Revolutions Serenex, a company dedicated to drug discovery, uses a proprietary matrix, or affinity media, to bind purine-binding protiens - a process that could transform the drug discovery business. mark for My Articles similar articles
Food Processing
March 2009
Diane Toops
Kraft Foods Global Thinks Outside the Box with Bioactive Ingredients Kraft hires a pharmaceutical company to help it develop functional foods. mark for My Articles similar articles
Chemistry World
May 17, 2006
Bea Perks
Biochemists Reveal Hidden Drug Effects Researchers have identified unexpected drug activities by probing biochemical pathways inside living cells. mark for My Articles similar articles
Chemistry World
December 19, 2011
Rebecca Trager
US agencies collaborate to test 10,000 chemicals A high-speed robotic screening system jointly initiated by three key US health agencies began testing more than 10,000 chemical compounds for potential toxicity on 7 December. mark for My Articles similar articles
Chemistry World
May 20, 2015
Katrina Kramer
Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs. mark for My Articles similar articles
HHMI Bulletin
Nov 2011
Sarah C.P. Williams.
Carolyn Bertozzi: Changed Expectations Chemists trained in biology were once a rarity -- now they're becoming the norm. mark for My Articles similar articles
Chemistry World
July 21, 2015
Ida Emilie Steinmark
Expert wiki to expose low-quality chemical probes After numerous examples of chemical probes ruining otherwise good research, the new project is looking to address the circulation of inferior probes, misuse of them and misleading studies. mark for My Articles similar articles
Chemistry World
July 26, 2012
Derek Lowe
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time. mark for My Articles similar articles
ONLINE
Sep/Oct 2007
Svetla Baykoucheva
A New Era in Chemical Information: PubChem, DiscoveryGate, and Chemistry Central How the emergence of PubChem, DiscoveryGate and Chemistry Central are changing the field of chemical information. mark for My Articles similar articles
Bio-IT World
October 10, 2003
Donna Mendrick
Microarrays That Make Drugs Safe Using DNA chips to discover potential toxicity in new drug compounds -- a key application of toxicogenomics -- can predict adverse effects before they occur, enabling safer clinical trials. mark for My Articles similar articles
Bio-IT World
April 15, 2003
Malorye Branca
Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease? mark for My Articles similar articles
Chemistry World
April 20, 2009
James Urquhart
New method reveals small molecule-RNA conjugates US scientists using novel chemical screening methods have discovered a new class of small molecules connected to RNA, suggesting that cellular RNA may be more chemically diverse than previously thought. mark for My Articles similar articles
Bio-IT World
December 15, 2003
Zachary Zimmerman
Learning the Language of Systems Biology Geneticist par excellence David Botstein talks about his philosophy, science, his mission for integrative science, and what he deems a success for systems biology. mark for My Articles similar articles
Chemistry World
June 2008
Sarah Houlton
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success mark for My Articles similar articles
IEEE Spectrum
March 2011
Lucks & Arkin
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering mark for My Articles similar articles
Industrial Physicist
Jennifer Ouellette
Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems mark for My Articles similar articles
Chemistry World
January 3, 2012
Simon Hadlington
One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division. mark for My Articles similar articles
Bio-IT World
Dec 2006/Jan 2007
Kevin Davies
The NextBio Thing in Bioinformatics NextBio, which this fall officially introduced its platform after a year of beta testing by a handful of select organizations, aims to provide high-throughput information to researchers without them having to learn anything. mark for My Articles similar articles
Wired
June 2000
Ed Regis
Greetings from Info Mesa Forget coyote art and adobe. Santa Fe's next claim to fame will be rescuing us from the digital data avalanche. mark for My Articles similar articles
Chemistry World
December 2008
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. mark for My Articles similar articles
Bio-IT World
April 2007
Vicki Glaser
Software Solutions for Medicinal Chemistry Driven by advances in chemical synthesis, instrumentation, and high-throughput and high-content screening technology, medicinal chemistry's transition from an art to a science is benefiting from a wealth of new software products, spanning both bio- and cheminformatics. mark for My Articles similar articles
Bio-IT World
June 17, 2004
John Garvey
Rational Decisions As companies in the computationally guided rational drug design sector mature, they should be more sure of the boundaries that surround their proprietary technologies. mark for My Articles similar articles
Bio-IT World
January 12, 2004
Karen Hopkin
High-Tech Search for the Fountain of Youth Dramatic advances may help biotechs develop drugs that slow aging. mark for My Articles similar articles
Chemistry World
March 5, 2015
Emma Stoye
Forgotten synthetic PhD theses set to be given new lease of life A team of researchers have amassed a digital collection of more than 75,000 compounds from PhD theses that might otherwise have mouldered in obscurity. mark for My Articles similar articles