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Chemistry World August 16, 2009 Tom Bond	Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.
Chemistry World March 10, 2006	Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates.
Chemistry World November 2010	Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize.
Chemistry World August 11, 2010 Simon Hadlington	Non-metal-catalysed C-C coupling Chinese chemists have successfully coupled aromatic molecules without the use of a transition metal catalyst - something that people have been trying to do for years with little success.
Chemistry World July 9, 2012 Phillip Broadwith	'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom.
Chemistry World October 6, 2010 Simon Hadlington	Trio share Nobel for palladium-catalysed cross-coupling Richard Heck of the University of Delaware in Newark, US, Ei-ichi Negishi of Purdue University, US, and Akira Suzuki of Hokkaido University in Japan, independently developed palladium-catalysed cross-coupling reactions as a way to forge new carbon-carbon bonds with precision
Chemistry World May 24, 2007 James Mitchell Crow	Palladium Coupling in Fewer Steps Look out Suzuki - Canadian chemists have successfully joined up simple benzene ring-like aromatics without any pre-activation.
Chemistry World October 29, 2009 Phillip Broadwith	Two metals are better than one UK chemists have developed reagents that can metallate ethers and ethene at room temperature without them disintegrating.
Chemistry World October 12, 2015 Emma Stoye	Chemistry Nobel laureate Richard Heck dies Richard Heck, the organic chemist who shared the 2010 chemistry Nobel prize with for developing palladium-catalyzed cross coupling reactions, has died aged 84.
Chemistry World May 8, 2012 Phillip Broadwith	Keep stirring that Suzuki The shape of your reaction vessel can influence the behavior of organotrifluoroborate compounds in Suzuki cross-coupling reactions, say chemists in the UK.
Chemistry World June 8, 2014 David Bradley	Carbon--carbon couplings go 3D Chemists have devised a new stereospecific coupling reaction for electron-rich aromatics using secondary and tertiary boronic esters that works under mild conditions.
Chemistry World April 10, 2008 Mark Peplow	'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis.
Chemistry World November 27, 2009 Simon Hadlington	A simple way to join an olefin to an arene Chemists in the US have developed a simple and effective way to carry out a key class of reaction in organic synthesis - the bolting an olefin to an aromatic ring.
Chemistry World February 20, 2012 James Urquhart	Unusual kinetics of catalyst revealed US researchers have elucidated the unusual reaction kinetics of C-H activation by the palladium(II) catalyst (Pd(OAc) 2).
Chemistry World February 22, 2008 James Mitchell Crow	Rhodium Fast Tracks Route to Lactones Chemists in Canada have developed an efficient new way to make lactones, chemical components of many natural products and drugs.
Chemistry World January 2012 Paul Docherty	Column: Totally Synthetic What a Japanese team demonstrates in this synthesis of dragmacidin D is the state of the art, uniting all the key fragments using C-H bond couplings.
Chemistry World March 24, 2015 Karl Collins	Back to basics for silylation While silicon is probably most familiar in organic synthesis as part of protecting groups, its utility extends much further.
Chemistry World June 10, 2010 Simon Hadlington	Elusive intermediate snared Chemists in Germany have succeeded in trapping an elusive intermediate involved in a key synthetic reaction catalysed by an organic molecule.
Chemistry World March 19, 2009 Manisha Lalloo	Copper catalysts give meta aromatics UK Researchers have discovered that, simply by using a copper catalyst, they are able to perform tricky substitution reactions at a difficult position on benzene rings
Chemistry World September 4, 2008 Fred Campbell	Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World October 2009	Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions
Chemistry World June 24, 2010 Phillip Broadwith	Aryl rings get a fluorine fix A mild and effective method for coupling trifluoromethyl groups on to aryl rings has been developed by US chemists.
Chemistry World August 1, 2013 James Urquhart	Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.
Chemistry World August 22, 2014 Derek Lowe	Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today.
Chemistry World August 14, 2014 Elisabeth Ratcliffe	Photoredox route to medically-important heterocycles Researchers in the US have developed a new photo catalyzed coupling reaction that could provide a pathway to a huge number of biologically active compounds.
Chemistry World January 14, 2015 Karl Collins	Alkynes reverse reactivity Coupling together thiols and alkynes -- both inherently nucleophilic species -- is a tricky prospect.
Chemistry World June 2007 Dylan Stiles	Opinion: Bench Monkey This PhD student takes an organic chemist's tour around the periodic table.
Chemistry World August 30, 2009 Phillip Broadwith	C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.
Chemistry World June 1, 2012 Mike Sutton	A reluctant chemist A century after Francois Auguste Victor Grignard's Nobel prize, organic chemists are still using the reagents he developed.
Chemistry World February 13, 2014 Tim Wogan	Greener route to esters dodges toxic reactant The industrially important synthesis of esters could be set to become greener and safer as German chemists have found a way to use carbon dioxide in place of carbon monoxide for alkoxycarbonylation.
Chemistry World April 14, 2009 Lewis Brindley	Osmium and pyridine ring together Organic chemists in China have found a way to put osmium into a pyridine ring - leading to the synthesis of the first metallapyridinium complex.
Chemistry World September 28, 2015 Karl Collins	A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research.
Chemistry World November 1, 2007 Richard Van Noorden	Step Change for Organic Synthesis US chemists discovered how to attack a complex molecule's unreactive carbon-hydrogen bonds, without resorting to wasteful synthetic aids like protecting and directing groups.
Chemistry World March 25, 2011 Simon Hadlington	New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.
Chemistry World June 25, 2015 Karl Collins	Dispelling nickel's catalytic demons In the world of transition metal catalysis, some still consider nickel less worthy than other metals.
Chemistry World November 3, 2008 Simon Hadlington	Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?
Chemistry World June 19, 2013 John Hayward	Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide.
Chemistry World October 22, 2009 Simon Hadlington	Carbenes catalyse metal-metal bonds in organometallics Chemists in the US have discovered a novel way to transform organometallic compounds so that new metal-metal bonds are created.
Chemistry World December 17, 2009 Simon Hadlington	Single catalyst gives two products from racemic mixture Chemists in the US have demonstrated a remarkable reaction in which a single catalyst can transform a racemic mixture - molecules identical in every way except for their chirality - into two distinct enantiomerically pure products.
Chemistry World September 6, 2006 Michael Gross	Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses.
Chemistry World January 3, 2012 Simon Hadlington	One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division.
Chemistry World August 2008	Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?
Chemistry World November 25, 2014 James Urquhart	Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.
Chemistry World April 25, 2014 Derek Lowe	Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found.
Chemistry World December 20, 2007 Richard Van Noorden	Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial.
Chemistry World November 17, 2008 Simon Hadlington	Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions
Chemistry World June 1, 2006 Michael Gross	New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions.
Chemistry World August 12, 2015 Matthew Gunther	Chemists hold a candle to reagent preservation Scientists in the US now have a solution to end the build-up of chemical waste with a wax capsule that can protect reagents from the atmosphere.
Chemistry World November 2007 Derek Lowe	Column: In the Pipeline Chemists are finally going with the flow.