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Chemistry World May 12, 2008 Simon Hadlington	'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria.
Chemistry World March 30, 2011 Hayley Birch	Amino acid synthesis hints at how the genetic code expanded The detailed pathway for the biosynthesis of pyrrolysine - the 22nd and latest amino acid to be discovered - has been outlined by US researchers.
Chemistry World November 13, 2014 Katrina Kramer	Persuading proteins to form porous polyhedra Researchers in the US have designed a hollow cube out of naturally occurring proteins, something that was previously only possible with DNA.
Chemistry World May 7, 2014 Emma Stoye	Bacterium survives unnatural DNA transplant The first organism that can grow and replicate with an unnatural base pair in its DNA -- giving the cell six nucleotides instead of the usual four -- has been created by scientists in the US.
Chemistry World May 2008 Philip Ball i	Pulling our strings There is much more to DNA than that elegant double helix. The author explores the twists and tangles of chromatin.
Chemistry World February 3, 2013 Andy Extance	Enzyme draws nanopore protein sequencing nearer US scientists at the University of California, Santa Cruz, have made a key step towards nanopore protein sequencing, thanks to an 'unfoldase' enzyme. Mark Akeson's team exploited this enzyme to unravel proteins and pull them through nanopores.
HHMI Bulletin Feb 2011	DNA Curtains How proteins behave in such a crash test gives scientists data about their structural integrity, how they attach to DNA, and how they behave in a cell.
Chemistry World November 27, 2013 Jennifer Newton	A cytochrome from scratch Artificial proteins could be closer to participating in natural biochemical pathways after researchers show that bacteria will process amino acid sequences entirely unrelated to any natural protein to produce a fully functioning cytochrome.
Chemistry World October 31, 2008 Manisha Lalloo	DNA-rewinding protein discovered US scientists have found an enzyme that rewinds sections of DNA whose strands have mistakenly come apart.
Chemistry World August 26, 2014 Andy Extance	No-frills coats set a trend for designer viruses Dutch scientists have built a simple model of viruses' protective coats in an attempt to create viral mimics that could fight diseases, as opposed to causing them.
Chemistry World August 17, 2011 Josh Howgego	Worms Modified to Express Unnatural Amino Acids Unnatural amino acids have been expressed for the first time in complex multicellular organisms. Researchers hope this will open up new ways to track biochemical processes and disease pathways.
Chemistry World June 30, 2011 Laura Howes	Chemically evolved bacteria European scientists have created an Escherichia coli strain with a separate genome using chlorinated DNA.
Chemistry World December 21, 2006 Henry Nicholls	Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper.
Chemistry World September 17, 2012 Ian Le Guillou	Raising the curtain on single-stranded DNA Scientists have created microfluidic devices containing single-stranded DNA 'curtains' for the first time, allowing scientists to study its interactions with proteins in real time.
Chemistry World August 2, 2011 Phillip Broadwith	Protein synthesis hijacked to turn out cyclic peptides Japanese researchers have developed a way of reprogramming the genetic code and using bacteria to make and screen huge libraries of cyclic peptides using unnatural amino acids.
Chemistry World May 21, 2012 Simon Hadlington	Rewritable DNA for digital data storage A rewritable memory storage module can form the basis of a digital memory system, scientists suggest, with the cell being able to 'record' transient changes in its internal chemistry.
HHMI Bulletin February 2011 Michele Solis	Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time.
Chemistry World September 1, 2008 Hayley Birch	Cancer target structure unveiled Researchers in the US have produced the first detailed structure of a key protein involved in regulating cancer, an eagerly anticipated advance that should speed anti-cancer drug development.
HHMI Bulletin Nov 2011 Dave Mosher	A New PACE for Laboratory Evolution Researchers have found a way to accelerate evolution of molecules by harnessing viruses.
Chemistry World May 5, 2010 Mike Brown	Natural artificial muscles Scientists in Canada and the US have developed artificial proteins that mimic the elastic and mechanical properties of the muscle protein, titin.
Chemistry World July 21, 2011 Elinor Richards	Cell Control to Change Cell Function US scientists can now control the reactions occurring inside cells.
Chemistry World December 19, 2007 Simon Hadlington	Snapshot of Proteins Linked to Autism Researchers in France and the US have caught on camera the gentle embrace between two proteins that sit on either side of the junction between nerve cells. It's this short circuit that has thought to cause some types of autism.
Chemistry World May 15, 2014	It's life, but not as we know it A US team at The Scripps Research Institute in California, has unveiled the first living Escherichia coli cells with non-natural base pairs in their DNA.
HHMI Bulletin May 2010 Kendall Powell	Malaria's Weakness With different approaches, two HHMI researchers land on an enzyme critical to the malaria parasite's destructive ways.
Chemistry World October 19, 2015 Matthew Gunther	The house that DNA built The 2015 chemistry Nobel prize was awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA repair.
Chemistry World June 21, 2007 Simon Hadlington	Boron is Key to Antifungal Agent Researchers have shown that the presence of a boron atom is key to an antifungal agent being developed to treat infections of fingernails and toenails.
Chemistry World August 2007 Philip Ball	Opinion: The Crucible The twist on DNA
Chemistry World July 15, 2010 Simon Hadlington	Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.
Chemistry World January 30, 2014 Anthony King	Unnatural DNA links click for faster synthesis Human cells can still read strands of DNA correctly if they are stitched together using linkers not found in nature, a new study shows.
Chemistry World October 13, 2015 Simon Hadlington	DNA movement through motor proteins measured Researchers have adapted a method for DNA sequencing to measure directly and with exquisite sensitivity the movement of a single molecule of DNA as it is drawn through specialized motor proteins.
Chemistry World July 2008 Ananyo Bhattacharya	Sparks of creation Chemists are at the forefront of synthetic biology, the burgeoning field that could soon create artificial life.
HHMI Bulletin Aug 2011 Janelle Weaver	Leading a Double Life with CSF Lucky for us, the organs in our bodies come with a self-repair kit. Though regularly bombarded by harmful bacteria, more often than not they manage to heal themselves. How this happens has puzzled scientists, but now there may be some answers.
Chemistry World January 4, 2007 Henry Nicholls	Microscopic Lab Investigates Contents of a Cell It's small-scale science that could have a massive impact on research into cell biology. Scientists have produced a microscopic laboratory where they can count individual proteins in a single cell.
Chemistry World October 7, 2015 Matthew Gunther	DNA repair research takes the 2015 chemistry Nobel The 2015 Nobel Prize in chemistry has been awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for unraveling how cells deal with DNA damage.
Technology Research News March 24, 2004	DNA has nano building in hand Researchers from Ludwig Maximilians University in Germany have built a simple molecular machine from DNA that can bind to and release single molecules of a specific type of protein.
Chemistry World August 26, 2008 Fred Campbell	High-throughput protein microarrays on the way A new method to rapidly generate protein microarrays has been developed by UK researchers at the University of Manchester.
Chemistry World October 1, 2014 Michael Gross	Viruses melt 'glassy' DNA US Researchers have identified the factors that enable viral DNA to turn from solid to liquid, which allows them to infect host cells. They say the process could become a target for new antiviral therapies.
HHMI Bulletin Spring 2013 Sarah C.P. Williams	Sounding the Alarm Details on how cells detect and respond to foreign DNA may provide clues to autoimmune diseases.
IEEE Spectrum March 2011 Lucks & Arkin	Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering
Pharmaceutical Executive November 1, 2006	Thoughtleader: Making Things Stick Ambrx has created the "glue" that allows researchers to attach activity-enhancing molecules to amino acids where they couldn't before.
Chemistry World June 1, 2009 Phillip Broadwith	Wider therapeutic possibilities for botulinum toxin Change to a single amino acid in botulinum toxin A causes it to target non-neuronal signalling proteins, potentially widening the product's therapeutic applications
Chemistry World August 4, 2011 Sarah Houlton	Targeting DNA Packaging to Treat Leukaemia Scientists in the US have found a new drug target that could be important in treating acute myeloid leukaemia.
Industrial Physicist	Biomimetic Nanotechnology Although biomimetic nanotechnology is in its infancy, with no applications yet reaching commercialization, the barriers in some cases lie mainly in scaling up production processes to industrial levels.
HHMI Bulletin February 2012 Sarah C. P. Williams	Force Factor In the context of cells, forces are required to move molecules. Quantifying these forces gives scientists a way to compare and contrast different molecular motors.
Chemistry World December 12, 2006 Michael Gross	Ancient Protein Moonlights in the Eye A structural protein in the mouse eye lens is the evolutionary descendant of an ancient bacterial enzyme, researchers have found -- suggesting that moonlighting saved the protein from oblivion when its original role was taken over by a different family of enzymes.
Chemistry World June 14, 2011	A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR.
Chemistry World January 19, 2010 Simon Hadlington	New 'click' reaction to modify proteins Chemists in the US have discovered a new way to attach small molecules to proteins and peptides under mild, aqueous reaction conditions.
Bio-IT World July 15, 2003 Julia Boguslavsky	'Fingerprinting' a Single Cell Single-cell proteomics is finally within reach, thanks to a professor of analytical chemistry.
Chemistry World January 12, 2015 Emma Stoye	Protein mutant libraries to probe diseases' genetic link quickly and cheaply Researchers in the US have developed a faster and less costly way to investigate the effects of genetic mutations on proteins, which should offer new insights into hereditary diseases.
Chemistry World March 1, 2010 Andy Extance	Bacterial mix sweetens biodrug synthesis Bacteria welcome in the human gut are set to become better factories for biological drugs thanks to modified genes from another, gastroenteritis-causing, species.