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HHMI Bulletin February 2011 Michele Solis |
Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time. |
Chemistry World December 21, 2006 Henry Nicholls |
Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper. |
Chemistry World August 26, 2008 Fred Campbell |
High-throughput protein microarrays on the way A new method to rapidly generate protein microarrays has been developed by UK researchers at the University of Manchester. |
Chemistry World November 13, 2014 Katrina Kramer |
Persuading proteins to form porous polyhedra Researchers in the US have designed a hollow cube out of naturally occurring proteins, something that was previously only possible with DNA. |
HHMI Bulletin May 2012 Sarah C. P. Williams |
Opening the Floodgates Researchers are using exome sequencing -- zeroing in on the genes that encode proteins -- to explore the biology of certain diseases. |
HHMI Bulletin Fall 2012 Ingfei Chen |
Same But Not Equal A code within the genetic code explains why identical proteins are produced at varying speeds. |
Bio-IT World November 2005 |
News Blast Applied Biosystems contributes 400,000 primers... Researchers have discovered the full genetic sequence of many different strains of the flu... Sigma-Aldrich launches Panorama Human Cancer Version 1 Protein Functional Microarray... |
Chemistry World October 8, 2008 Sarah Houlton |
Artificial protein chemistry licensed to industry UK researchers are licensing to industry their method of making artificial proteins by chemically modifying individual amino acid structures. |
Technology Research News March 24, 2004 |
DNA has nano building in hand Researchers from Ludwig Maximilians University in Germany have built a simple molecular machine from DNA that can bind to and release single molecules of a specific type of protein. |
HHMI Bulletin Nov 2010 Sarah C.P. Williams |
Scientists Track Down Genetic Mutations In Record Time Scanning the human genome for a single disease-causing mutation is like taking a copy of War and Peace in a foreign language and searching for one misspelled word |
Chemistry World June 7, 2007 Jessica Ebert |
Sensitive Sequencing Technique for Early Diagnosis A new technique, with sensitivity unmatched by current technologies, can detect changes in gene transcription that occur during the course of a disease, report US researchers. |
HHMI Bulletin Aug 2010 |
Joaquin Espinosa's fresh look at p53 Even though it was discovered more than 25 years ago, and many more tumor suppressor genes have been found since, p53 remains the big one. It's mutated in about 50 percent of tumors. |
Chemistry World April 27, 2006 |
`Sticky Trees' Glue Molecules to Proteins Researchers have developed a chemical glue that binds molecules to proteins without compromising protein function. The method could be used to modify a wide range of proteins for a variety of purposes, such as in the development of new protein-based therapies. |
Chemistry World November 27, 2013 Jennifer Newton |
A cytochrome from scratch Artificial proteins could be closer to participating in natural biochemical pathways after researchers show that bacteria will process amino acid sequences entirely unrelated to any natural protein to produce a fully functioning cytochrome. |
Chemistry World August 26, 2014 Andy Extance |
No-frills coats set a trend for designer viruses Dutch scientists have built a simple model of viruses' protective coats in an attempt to create viral mimics that could fight diseases, as opposed to causing them. |
PC Magazine July 13, 2005 John R. Quain |
DNA Printing Press A group of scientists believes it has an inexpensive nanoprinting technique that could lead to the mass production of DNA-based chips that could revolutionize disease detection. |
Chemistry World August 3, 2009 Simon Hadlington |
Computational chemistry predicts flu mutations Researchers in the US have shown how it might be possible to use computational chemistry to predict which mutations in a key influenza virus protein could lead to dangerous new strains of the disease. |
IEEE Spectrum March 2011 Lucks & Arkin |
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering |
HHMI Bulletin Feb 2011 |
DNA Curtains How proteins behave in such a crash test gives scientists data about their structural integrity, how they attach to DNA, and how they behave in a cell. |
Pharmaceutical Executive November 1, 2006 |
Thoughtleader: Making Things Stick Ambrx has created the "glue" that allows researchers to attach activity-enhancing molecules to amino acids where they couldn't before. |
HHMI Bulletin Nov 2011 Dave Mosher |
A New PACE for Laboratory Evolution Researchers have found a way to accelerate evolution of molecules by harnessing viruses. |
Chemistry World July 16, 2009 James Urquhart |
New DNA technique sheds light on ancient populations A new sequencing technique that is cheaper and less wasteful has been used to decode and analyse the mitochondrial genomes of five Neanderthal individuals. |
Chemistry World January 30, 2014 Anthony King |
Unnatural DNA links click for faster synthesis Human cells can still read strands of DNA correctly if they are stitched together using linkers not found in nature, a new study shows. |
Chemistry World June 26, 2008 Bea Perks |
Liquid Crystals Stand up for DNA Detection Liquid crystals that realign in response to DNA can reveal subtle sequence alterations, even a single base mutation, report US scientists. |
Chemistry World February 18, 2008 John Bonner |
Flicking the Acetyl Switch A strain of Escherichia coli that can produce proteins containing an acetylated version of the amino acid lysine could help to reveal how acetylation changes the function of hundreds of proteins inside cells. |
Bio-IT World October 10, 2003 Mel Kronick |
In Situ Chips on Demand Microarray manufacturing technologies are giving new meaning to the term 'custom.' |
Chemistry World September 17, 2012 Ian Le Guillou |
Raising the curtain on single-stranded DNA Scientists have created microfluidic devices containing single-stranded DNA 'curtains' for the first time, allowing scientists to study its interactions with proteins in real time. |
Chemistry World June 2, 2015 Tim Wogan |
Simple sensor can spot cancer markers in minutes An electrochemical sensor that can detect specific mutant nucleic acids from cancers in blood samples could allow quick and cheap 'liquid biopsies'. |
Chemistry World January 11, 2008 John Bonner |
DNA Nanoparticles Detect Gene Expression US scientists have made nanoparticles from DNA that they say could be used to identify the genes being expressed in a single cell. |
Bio-IT World October 10, 2003 Jeffrey Skolnick |
Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways. |
Chemistry World February 3, 2013 Andy Extance |
Enzyme draws nanopore protein sequencing nearer US scientists at the University of California, Santa Cruz, have made a key step towards nanopore protein sequencing, thanks to an 'unfoldase' enzyme. Mark Akeson's team exploited this enzyme to unravel proteins and pull them through nanopores. |
Chemistry World October 6, 2014 Emma Stoye |
BRCA2 protein imaged for first time The first detailed images of BRCA2 -- have revealed its structure and the mechanism by which it works, offering hope for new treatments. |
HHMI Bulletin February 2011 Sarah C.P. Williams |
Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
Bio-IT World April 15, 2003 Malorye Branca |
Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease? |
Bio-IT World June 12, 2002 Mark D. Uehling |
Putting Proteins in Their Place Will a 'periodic table' of proteins help classify the ungainly beasts? |
Chemistry World October 19, 2015 Matthew Gunther |
The house that DNA built The 2015 chemistry Nobel prize was awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA repair. |
Chemistry World June 1, 2012 Simon Hadlington |
Protein architecture with atomic precision Researchers have made a key breakthrough in designing and building geometrically defined nanostructures from proteins with unprecedented accuracy. |
Chemistry World June 2, 2006 Jon Evans |
Axons Get Directions Scientists are a step closer to understanding the processes that control the growth and spread of nerve cells, following the discovery of a protein complex that directs the transport of building material to growing axons. |
BusinessWeek June 13, 2005 John Carey |
The NIH's Roadmap for Research Charting the human genome was just the beginning. Now the focus is creating pathways that will lead to practical applications. |
Chemistry World May 11, 2011 Laura Howes |
Small molecule hope for muscular dystrophy Prompted by the case of a small boy who ought to have muscular dystrophy but doesn't, Japanese researchers have discovered a small molecule that they hope will treat the disease. |
Chemistry World May 12, 2008 Simon Hadlington |
'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria. |
Chemistry World March 1, 2011 Catherine Bacon |
Unravelling chromosomes Danish scientists have used a micro device to isolate centimetre-long portions of human DNA to help study the genetic make-up of diseased cells. |
Chemistry World August 2007 Philip Ball |
Opinion: The Crucible The twist on DNA |
Chemistry World October 27, 2014 Tim Wogan |
Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability. |
Chemistry World July 2010 Anna Lewcock |
Medicine made to measure Healthcare tailored to suit the genetic makeup of the patient is finally coming to fruition. |
Bio-IT World June 12, 2002 Karen Hopkin |
Computational Biologists Join the Fold CASP5 competitors compare the best algorithms for modeling the 3-D structure of proteins -- an exercise that could lead to new insights into the pathogenesis and treatment of disease. |
Salon.com December 19, 2000 Carolyn McConnell |
"The Century of the Gene" by Evelyn Fox Keller A new book argues that there may be no such thing as a gene. At least, it has proved very difficult to isolate a discrete physical item that can do the work our notion of the gene does... |
HHMI Bulletin May 2011 Sarah C.P. Williams |
The Pace of Evolution A close look at the human genome shows the slow and steady beat of adaptation. |
Chemistry World October 13, 2015 Simon Hadlington |
DNA movement through motor proteins measured Researchers have adapted a method for DNA sequencing to measure directly and with exquisite sensitivity the movement of a single molecule of DNA as it is drawn through specialized motor proteins. |