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HHMI Bulletin February 2011 Sarah C.P. Williams	Releasing the Brakes on Cell Fate Converting one cell type directly into another is a kind of modern-day alchemy, an ultimate goal in biological research. But unlike turning base metals into gold, changing a cell's identity is feasible, new research shows.
Chemistry World January 4, 2007 Henry Nicholls	Microscopic Lab Investigates Contents of a Cell It's small-scale science that could have a massive impact on research into cell biology. Scientists have produced a microscopic laboratory where they can count individual proteins in a single cell.
Bio-IT World July 15, 2003 Julia Boguslavsky	'Fingerprinting' a Single Cell Single-cell proteomics is finally within reach, thanks to a professor of analytical chemistry.
Chemistry World February 23, 2009 Nina Notman	Resistant breast cancers re-sensitised to Tamoxifen A way to re-sensitise certain drug-resistant breast cancers to treatments such as Tamoxifen could offer better treatment for people with hard-to-beat cancers.
HHMI Bulletin February 2011 Sarah C.P. Williams	Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions.
Chemistry World November 25, 2013 Carla Pegoraro	Steering cells towards biocomputers Bacterial toxins that undergo unique cell interactions have been used to perform logic functions by researchers in Germany. This innovation will help push the limits of synthetic biology.
Chemistry World February 12, 2009 Simon Hadlington	Mystery receptor's binding partner uncovered For decades scientists have puzzled over the role of the sigma-1 receptor, a protein found in almost all mammalian cells, including the nervous system.
Chemistry World January 13, 2008 Ananyo Bhattacharya	Unexpected Effects of Drug Combinations Medicines that use a combination of several drugs can sometimes produce unexpected effects in patients. Now, a team of scientists think they have figured out how that can happen.
Chemistry World October 25, 2007	Elusive Drug Target Finally Seen Scientists have captured an atomic-scale picture of a receptor protein from a family that is the target of thousands of drugs.
HHMI Bulletin Aug 2011 Cassandra Willyard	A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice.
Chemistry World May 17, 2007 Richard Van Noorden	Bacterial Navigation Reprogrammed U.S. scientists have forced bacteria to follow new chemical signals by tweaking the bugs' natural guidance system.
Managed Care May 2004 Thomas Morrow	New Agents Regulating Tyrosine Kinase Can Be Used Against Several Cancers When traditional therapies fail in cancer treatment, turning off a chemical switch may offer hope to the hopeless.
Scientific American June 2008 Melinda Wenner	How Cells Make Use of Random Biochemical Reactions New studies reveal how cells exploit biochemical randomness.
Chemistry World October 9, 2011 Simon Hadlington	New probe throws light on cellular lipids Scientists in the US have developed a new sensor that can track and measure lipids in living cells.
Chemistry World October 2, 2012 Fiona McKenzie	Protein sorting within cells US scientists have used magnetic nanoparticles with specific ligands to latch on to and visualize specific proteins in living cells.
HHMI Bulletin May 2012 Elise Lamar	Cells on the Move The biochemical signals that set cells on a journey are as diverse as the tissues they move through, but the engine is driven by constant remodeling of a protein network built from a box of cellular Legos.
HHMI Bulletin May 2010 Sarah C.P. Williams	Lab-Grown Liver New cell culture system solves problem of growing liver cells.
HHMI Bulletin Winter 2013 Sarah C.P. Williams	Cellular Search Engine Craig Mello's lab has now uncovered the reason piRNA molecules are so ubiquitous and exist in so many forms in C. elegans: so they can pair with essentially any genetic sequence they encounter during their endless scanning.
HHMI Bulletin Aug 2010 Sarah C.P. Williams	Fruit Fly Cells Don't All Know What Sex They Are HHMI scientists have now found that many cells in male and female fruit flies not only look the same, they are more identical at a molecular level than was previously thought.
Chemistry World September 10, 2008 Simon Hadlington	Failed anxiety drug could treat cancer Scientists believe they have solved the mystery of how a drug originally developed for treating anxiety can kill cancer cells.
Chemistry World May 26, 2011 Russell Johnson	Hunting elusive green fluorescent proteins After a 40 year hunt, scientists have tracked down the genes responsible for fluorescent proteins in Obelia medusa - a type of jellyfish. Knowledge of these genes could lead to new fluorescent protein tags for use in cell biology.
Chemistry World April 2010	Column: The crucible We are getting better at manipulating cells to grow into the tissues we need. Chemical factors are key, says Philip Ball
HHMI Bulletin Aug 2010 Richard Saltus	Three-Dimensional Cell Cultures Thinking big but starting small, Sangeeta Bhatia is closing in on her ambitious goal: growing human livers in the lab from scratch.
Chemistry World December 9, 2013 James Urquhart	Drug fix for misfolded proteins promises hope for incurable diseases Researchers have been looking into pharmacological chaperones or pharmacoperones. They might treat diseases brought about by genetic mutations that cause otherwise functional proteins to become misfolded or misrouted.
Reason October 2001 Ronald Bailey	Blastocyst Brouhaha Which human cells count as people?
Chemistry World October 23, 2011 David Bradley	Clicking Together Cultural Niches Researchers in the US have made three-dimensional hydrogels that are not only compatible with living cells but can be tuned to create specialist growing environments - culture niches - for studying cell function.
Chemistry World May 12, 2008 Simon Hadlington	'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria.
Chemistry World September 7, 2008 Simon Hadlington	Coupled proteins to reveal drug hits Researchers in France have successfully attached an 'electrical switch' to a key class of membrane proteins targeted by many drugs.
Chemistry World October 7, 2012 David Bradley	Magnetic nanoparticles zap cancer Nanoparticles can be used as a remote-controlled magnetic death switch to kill cancer cells, according to researchers from Korea.
HHMI Bulletin May 2010 Ivan Arnato	Light Moves Light is becoming the tool of choice for researchers who want to precisely manipulate neurons and other cells.
Chemistry World February 13, 2006	Nanoparticles Detect Cell Suicide Plans Researchers have developed a nanotechnological assay for detecting programmed cell death. The technique is effective in cell cultures, they report, and might eventually be used in humans.
Scientific American July 2008 Sally Lehrman	Dolly's Creator Moves Away from Cloning and Embryonic Stem Cells Like many stem cell pioneers, Ian Wilmut, the creator of Dolly the sheep, has jumped to an alternative approach. Is this the beginning of the end for embryonic cloning?
Chemistry World June 27, 2010 Simon Hadlington	Nanoparticles allow remote control of cells In an experiment reminiscent of the mind-control rays that featured prominently in B-movies from the 1950s, scientists in the US have used a magnetic field to alter the behavior of an animal.
IEEE Spectrum August 2006 Schoenbach et al.	Zap Extreme voltage could be a surprisingly delicate tool in the fight against cancer. The list of effects that scientists have achieved using nanoseconds-long pulses is growing rapidly, though their actual use as a medical treatment is still years away.
Chemistry World July 27, 2015 Tim Wogan	Repellent nanocraters could shape tissue engineering Patterning surfaces with nanoscale craters can interfere with cells' ability to stick to surfaces, researchers in the US have shown.
Bio-IT World July 2005 David M. Evans	Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior.
Chemistry World February 2012	Column: The crucible To understand the chemical choreography of the cell, we must acknowledge the bustling biomolecular ballroom in which it takes place, says Philip Ball
Scientific American January 17, 2007 Charles Q. Choi	A Stroke for Stem Cells The brain becomes a target in stem cell clinical trials.
Chemistry World November 12, 2009 Hayley Birch	New drug design looks top Notch against cancer A new type of drug that can block the switching on of certain genes in cancer cells has shown promise in mice.
Chemistry World March 10, 2011 Elinor Richards	3D model to study breast cancer Scientists from the US have made a computational model of the formation of breast acini, the sac-like part of the milk-producing glands, to understand complex events occurring during the progression of breast cancer.
Chemistry World August 2, 2011 Kate McAlpine	Hacking into chemical cell phone calls US researchers have made a nanodevice that can eavesdrop on a cell's mutterings, and they say it could be adapted to listen in on conversations between cells.
Chemistry World August 15, 2007 John Bonner	Chemists Claim Biological Alchemy South Korean chemists say they have turned muscle cells from the sole of a human foot into something akin to stem cells, using a simple molecule called neurodazine.
HHMI Bulletin Spring 2013 Sarah C.P. Williams	Sounding the Alarm Details on how cells detect and respond to foreign DNA may provide clues to autoimmune diseases.
HHMI Bulletin Aug 2011 Sarah C.P. Williams	The Goldilocks of Cells Too much or too little cell death can lead to disease. Scientists are learning how to find the range that's just right.
HHMI Bulletin Winter 2013 Amber Dance	A Trick of Light When miniSOG protein takes in blue light, it converts ordinary oxygen into a short-lived, excited state called singlet oxygen, which reacts with and changes the molecules around it. The singlet oxygen destroys the mitochondria's delicate machinery.
Chemistry World April 2, 2009 Michael Gross	Light-guided hydrogels direct cell growth Researchers in the US have developed a gel-like material whose structural and chemical properties can change in response to laser light
HHMI Bulletin May 2012 John Roach	Tiny Breathing Plant Mouths Keiko Torii was drawn from an interest in cancer research to a career in plant biology, but keeps her eyes open for relevance in both areas.
HHMI Bulletin Spring 2013 Nicole Kresge	Use It or Lose It HHMI investigator Catherine Dulac of Harvard University has uncovered a small molecule that plays a big role in the process of tuning olfactory neurons to the environment.
Chemistry World January 10, 2008 Simon Hadlington	Proton Joins Elite Club of Cellular Messengers Researchers have discovered a new chemical that carries messages rapidly between cells - the first for more than 20 years. But unlike conventional signalling molecules, this is a far simpler chemical entity: it is the humble proton.
Scientific American September 19, 2005 Charles Q. Choi	Chatting Up Cells Stem cells can transform into whatever cell the body tells them to. Unfortunately, scientists have yet to master that particular gift of gab. But investigators may soon crack the language with tiny "chat rooms" for stem cells.