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Chemistry World October 18, 2012	A signal honor The 2012 Nobel prize in chemistry was awarded to Robert Lefkowitz and Brian Kobilka for studies of G-protein-coupled receptors. This article looks at the molecular machinery underpinning cell signaling.
Chemistry World January 13, 2008 Ananyo Bhattacharya	Unexpected Effects of Drug Combinations Medicines that use a combination of several drugs can sometimes produce unexpected effects in patients. Now, a team of scientists think they have figured out how that can happen.
Chemistry World September 7, 2008 Simon Hadlington	Coupled proteins to reveal drug hits Researchers in France have successfully attached an 'electrical switch' to a key class of membrane proteins targeted by many drugs.
Chemistry World July 21, 2011 Elinor Richards	Cell Control to Change Cell Function US scientists can now control the reactions occurring inside cells.
Chemistry World October 10, 2012 Phillip Broadwith	Chemistry Nobel awarded for protein receptors The 2012 Nobel prize in chemistry has been awarded to Robert Lefkowitz of the Howard Hughes Medical Institute and Duke University in Durham, US, and Brian Kobilka of Stanford University, US, for 'studies of G-protein coupled receptors'.
Chemistry World October 9, 2011 Simon Hadlington	New probe throws light on cellular lipids Scientists in the US have developed a new sensor that can track and measure lipids in living cells.
HHMI Bulletin Nov 2011 Nicole Kresge	Unlocking the Interferon Puzzle Scientists show that interferon signaling depends on bond strength.
HHMI Bulletin Winter 2013 Sarah Goforth	Rational Exuberance Trained as a cardiologist, Robert Lefkowitz is the first to admit that his 39-year research career has been driven by more than a desire to treat coronary disease. He has always had an unshakeable urge to figure things out.
Chemistry World April 19, 2011 Simon Hadlington	Cell factories package drugs for delivery Scientists in Australia and Germany have used living cells as 'factories' to encapsulate particles such as drugs in biological membranes.
Chemistry World March 6, 2011 Mike Brown	Molecules that walk, hop and jump 'Two legged' molecules walk, hop and fly across a receptor surface, according to researchers in the Netherlands and Ireland. The findings could help us understand how viruses and bacteria interact with cell membranes, they say.
HHMI Bulletin Feb 2012 Nicole Kresge	Now You See It, Now You Don't A disappearing receptor could hold the key to beta-cell growth and insulin production.
Chemistry World August 12, 2011 Manisha Lalloo	Unraveling cell membranes to understand drugs Researchers in Sweden have found a way to create flattened cell membranes, known as supported lipid bilayers, out of real cell structures.
Chemistry World April 12, 2011 Meera Senthilingam	How antidepressants spur brain growth Researchers have identified the mechanism by which some antidepressants stimulate the formation of new brain cells, an insight that could lead to improved drugs.
Chemistry World December 5, 2007 Ananyo Bhattacharya	Structural Snapshot Shows Monster Protein A structural snapshot of a protein capsule has revealed details of the largest cellular component ever imaged by x-ray crystallography.
Chemistry World July 6, 2007 Michael Gross	Predicting How Proteins Fold Researchers in Italy and the UK have now developed a computational approach that can simulate the folding of membrane proteins in atomic detail.
Chemistry World February 12, 2009 Simon Hadlington	Mystery receptor's binding partner uncovered For decades scientists have puzzled over the role of the sigma-1 receptor, a protein found in almost all mammalian cells, including the nervous system.
Chemistry World January 19, 2011 Jon Cartwright	Modified protein binders give shortcut to drugs The method, which involves attaching polypeptides to the binders, could help reduce the work required to develop protein binders into safer drugs.
HHMI Bulletin Spring 2013 Nicole Kresge	A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology.
HHMI Bulletin May 2012 Nicole Kresge	Locating a Genetic Glitch A team of 41 scientists led by HHMI investigator Louis Ptacek has pinpointed the gene responsible for a rare disease that causes sudden, uncontrollable movements. The culprit is a little known protein that may be responsible for communication between neurons.
HHMI Bulletin February 2011 Sarah C.P. Williams	Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions.
Chemistry World December 21, 2006 Henry Nicholls	Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper.
Chemistry World November 2, 2009 Simon Hadlington	New way to find drugs' unintended targets Researchers in the US have devised a new way to predict 'off-target' effects for pharmaceutical drugs.
Chemistry World October 27, 2014 Tim Wogan	Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability.
HHMI Bulletin Winter 2013 Nicole Kresge	A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure.
Chemistry World March 17, 2009 Phillip Broadwith	Electronic 'nose' could shed light on sense of smell Korean researchers have combined human smell receptors with nanotechnology to create a new kind of 'bio-electronic nose'
Chemistry World February 23, 2009 Nina Notman	Resistant breast cancers re-sensitised to Tamoxifen A way to re-sensitise certain drug-resistant breast cancers to treatments such as Tamoxifen could offer better treatment for people with hard-to-beat cancers.
Chemistry World September 10, 2008 Simon Hadlington	Failed anxiety drug could treat cancer Scientists believe they have solved the mystery of how a drug originally developed for treating anxiety can kill cancer cells.
Chemistry World January 5, 2009 Hayley Birch	How to Strengthen the Taste of Umami US scientists say they have uncovered a unique mechanism by which molecules drastically enhance umami flavour - the savoury taste associated with protein-rich foods such as meat, cheese and seafood.
Chemistry World September 1, 2008 James Mitchell Crow	Drug discovery on a chip Scientists in the US have, for the first time, used microfluidics to discover drug leads. The team's lab-on-a-chip device revealed inhibitors of a key membrane-bound protein in hepatitis C virus
Reactive Reports Apr/May 2005 David Bradley	Of Mice and Women Mice lacking a molecule usually found on the surface of cells in the womb have fertility problems, according to a study by researchers.
Chemistry World April 26, 2009 Simon Hadlington	Glowing protein in 'animal photosynthesis' Scientists have discovered that a glowing protein found in some exotic marine animals and used widely as a 'marker' in molecular biology has another remarkable property
Chemistry World January 5, 2007 Victoria Gill	PEG Makes Cheaper Drugs for Developing Countries UK and Indian scientists have embarked on a collaboration to develop a new protein-based treatment for hepatitis C, which they say will provide an affordable drug urgently needed in countries where resources are limited.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World April 8, 2010 Simon Hadlington	Arsenic anticancer target revealed Researchers from China and France believe they have uncovered the molecular mechanism by which arsenic trioxide kills certain cancer cells.
Pharmaceutical Executive November 1, 2006	Thoughtleader: Making Things Stick Ambrx has created the "glue" that allows researchers to attach activity-enhancing molecules to amino acids where they couldn't before.
Chemistry World October 8, 2008 Sarah Houlton	Artificial protein chemistry licensed to industry UK researchers are licensing to industry their method of making artificial proteins by chemically modifying individual amino acid structures.
Managed Care May 2004 Thomas Morrow	New Agents Regulating Tyrosine Kinase Can Be Used Against Several Cancers When traditional therapies fail in cancer treatment, turning off a chemical switch may offer hope to the hopeless.
Chemistry World February 3, 2013 Andy Extance	Enzyme draws nanopore protein sequencing nearer US scientists at the University of California, Santa Cruz, have made a key step towards nanopore protein sequencing, thanks to an 'unfoldase' enzyme. Mark Akeson's team exploited this enzyme to unravel proteins and pull them through nanopores.
Chemistry World October 21, 2010	Studies Probe Key Flu Protein New details about the structure of an influenza protein that is a key drug target have been revealed in separate studies by groups in the US. The two studies provide insights into the workings of the protein machinery that the virus needs to infect cells.
Chemistry World June 14, 2011	A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR.
Chemistry World December 9, 2013 James Urquhart	Drug fix for misfolded proteins promises hope for incurable diseases Researchers have been looking into pharmacological chaperones or pharmacoperones. They might treat diseases brought about by genetic mutations that cause otherwise functional proteins to become misfolded or misrouted.
Bio-IT World October 10, 2003 Jeffrey Skolnick	Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways.
Chemistry World January 10, 2008 Simon Hadlington	Proton Joins Elite Club of Cellular Messengers Researchers have discovered a new chemical that carries messages rapidly between cells - the first for more than 20 years. But unlike conventional signalling molecules, this is a far simpler chemical entity: it is the humble proton.
Reactive Reports Issue 51 David Bradley	Cannabinoids and Osteoporosis Researchers have discovered a regulatory mechanism involved in bone loss linked to a chemical receptor in our bodies with a previously unknown function, which could lead to a new treatment.
Bio-IT World June 12, 2002 Karen Hopkin	Computational Biologists Join the Fold CASP5 competitors compare the best algorithms for modeling the 3-D structure of proteins -- an exercise that could lead to new insights into the pathogenesis and treatment of disease.
Chemistry World October 7, 2012 David Bradley	Magnetic nanoparticles zap cancer Nanoparticles can be used as a remote-controlled magnetic death switch to kill cancer cells, according to researchers from Korea.
Chemistry World August 31, 2007 Lionel Milgrom	Gut's Taste for the Sweet Life Revealed A sugar-sensing receptor in the intestine could explain why drinking diet cola may hinder obese people who hope to lose weight and lead to new ways of treating obesity and diabetes.
Chemistry World January 31, 2007 Victoria Gill	LSD reveals its secrets A long-standing pharmacological mystery surrounding hallucinogens may finally have been solved by a new study.
Chemistry World August 22, 2008 Hayley Birch	Drug uptake rule challenged A study by UK scientists apparently contradicts a 100-year-old rule thought to govern the rate at which molecules cross biological membranes.
Bio-IT World January 21, 2005 Robert M. Frederickson	High-Throughput Science Although genomic assays led the charge toward high-throughput science, new detection systems and formats are enabling the application of high-throughput techniques to proteins and cells.