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Bio-IT World September 11, 2003 Julia Boguslavsky	Cellular Screening in Sync No longer just a 'good idea,' high-content cellular screening is making an impact in target and lead selection.
Bio-IT World December 15, 2003 Malorye A. Branca	Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful.
Bio-IT World April 2006 Robert M. Frederickson	High-Content Cell-Based Imaging Increasingly, equipment providers are incorporating modules for high-content and single-cell analyses into their drug discovery platforms. In addition, new strategies and equipment designs are bringing new types of analysis into the drug discovery marketplace.
Bio-IT World December 15, 2004 William Marshall	Applications of RNAi RNA interference is a highly coordinated gene regulatory mechanism that appears to be highly conserved across all metazoans studied thus far.
Bio-IT World March 2006 Robert M. Frederickson	Integration, Robotics, and Automation The integration of instruments and technology is a key concept driving the development of advanced life-sciences laboratory automation. More sophisticated robotics are also increasingly being integrated into automated systems.
Bio-IT World January 21, 2005 Robert M. Frederickson	High-Throughput Science Although genomic assays led the charge toward high-throughput science, new detection systems and formats are enabling the application of high-throughput techniques to proteins and cells.
Industrial Physicist Jennifer Ouellette	Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems
Bio-IT World Jul/Aug 2006 Deb Janssen	Managing the Microarray Data Mountain Genomic studies often involve thousands of samples and require hundreds of thousands of assays per sample. Microarray manufacturers are scurrying to satisfy researcher demands for increased array density, sample number, and content flexibility.
Bio-IT World July 11, 2002 Malorye Branca	Deep Sequence Diving Like sailors of old, genomic data miners dream of discovering riches and fame. Given the recent improvements in analytics -- and a little more time -- they just might succeed.
Chemistry World July 21, 2011 Elinor Richards	Cell Control to Change Cell Function US scientists can now control the reactions occurring inside cells.
Bio-IT World June 2006 Robert M. Frederickson	Tissue Microarray Hard and Software Technological advances in automated microscopes, digital image acquisition, and high-throughput screening techniques have led to the need for more sophisticated software tools, now offered through a collaboration between DMetrix, BioImagene, IBM and the Arizona Cancer Center.
Bio-IT World Dec 2006/Jan 2007 Kevin Davies	The NextBio Thing in Bioinformatics NextBio, which this fall officially introduced its platform after a year of beta testing by a handful of select organizations, aims to provide high-throughput information to researchers without them having to learn anything.
HHMI Bulletin Aug 2011 Sarah C.P. Williams	The Goldilocks of Cells Too much or too little cell death can lead to disease. Scientists are learning how to find the range that's just right.
Bio-IT World November 2006 Robert M. Frederickson	Managing Data on the Go GeneGo has created a suite of software and database products that aim to facilitate analysis of the biology behind different types of high-throughput experimentation and understand the effects of small molecule drug compounds in human tissues.
IEEE Spectrum March 2011 Lucks & Arkin	Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering
Chemistry World May 17, 2006 Bea Perks	Biochemists Reveal Hidden Drug Effects Researchers have identified unexpected drug activities by probing biochemical pathways inside living cells.
HHMI Bulletin Winter 2013 Sarah C.P. Williams	Cellular Search Engine Craig Mello's lab has now uncovered the reason piRNA molecules are so ubiquitous and exist in so many forms in C. elegans: so they can pair with essentially any genetic sequence they encounter during their endless scanning.
Chemistry World September 17, 2012 Jennifer Newton	Seeing cells under stress An analytical platform that imposes controlled mechanical strain onto live cells while monitoring changes in cell morphology and molecular signalling has been developed by scientists in Germany.
HHMI Bulletin February 2011 Sarah C.P. Williams	Releasing the Brakes on Cell Fate Converting one cell type directly into another is a kind of modern-day alchemy, an ultimate goal in biological research. But unlike turning base metals into gold, changing a cell's identity is feasible, new research shows.
IEEE Spectrum August 2006 Schoenbach et al.	Zap Extreme voltage could be a surprisingly delicate tool in the fight against cancer. The list of effects that scientists have achieved using nanoseconds-long pulses is growing rapidly, though their actual use as a medical treatment is still years away.
Chemistry World June 13, 2011 Laura Howes	Cells turned into living lasers with fluorescent protein With a little help from a fluorescent protein, mammalian cells have been transformed into living lasers. This discovery could help improve imaging of living cells, enabling researchers to explore what's going on inside.
Bio-IT World May 9, 2003 Vivien Marx	The Sharper Image See it, capture it, mine it, find it. The budding field of image informatics is empowering biomedical research.
HHMI Bulletin Aug 2010 Richard Saltus	Three-Dimensional Cell Cultures Thinking big but starting small, Sangeeta Bhatia is closing in on her ambitious goal: growing human livers in the lab from scratch.
Bio-IT World July 2005 Stan Schwartz	Trends in Digital Bioscience Imaging The author, a Nikon VP, reviews the improvements in digital imaging that have been achieved over the last 30 years. A new set of research tools is aimed at solving the bottlenecks commonly found in the drug discovery laboratory.
Chemistry World December 13, 2010 James Urquhart	Nanotube probe for cellular studies A new way of peering inside biological cells using carbon nanotubes as tiny multifunctional endoscopes has been developed by US researchers.
Chemistry World July 17, 2012 Simon Perks	Synthetic nanozymes silence hepatitis C Researchers at the University of Florida, US, have discovered that an artificial nanoparticle complex, known as a nanozyme, can help to treat viral infections by 'shutting off' their genetic material.
Bio-IT World February 10, 2003 Malorye Branca	Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic.
HHMI Bulletin Fall 2012 R. John Davenport	Hanchuan Peng: SmartScopes Even when he launched his career as an engineer and computer scientist, Hanchuan Peng was drawn to the beauty of biology. He is a leader in developing sophisticated ways to make sense of biological images.
HHMI Bulletin May 2012 Elise Lamar	Cells on the Move The biochemical signals that set cells on a journey are as diverse as the tissues they move through, but the engine is driven by constant remodeling of a protein network built from a box of cellular Legos.
HHMI Bulletin Spring 2013 Sarah C.P. Williams	Sounding the Alarm Details on how cells detect and respond to foreign DNA may provide clues to autoimmune diseases.
HHMI Bulletin May 2010 Ivan Arnato	Light Moves Light is becoming the tool of choice for researchers who want to precisely manipulate neurons and other cells.
HHMI Bulletin Fall 2012 Ivan Amato	The View from Here "Every major advance in imaging technology precipitates a new round of breakthroughs in cell biology," says structural biologist Grant Jensen, an HHMI investigator at the California Institute of Technology.
Chemistry World August 4, 2011 Sarah Houlton	Targeting DNA Packaging to Treat Leukaemia Scientists in the US have found a new drug target that could be important in treating acute myeloid leukaemia.
HHMI Bulletin February 2011 Sarah C.P. Williams	Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions.
Chemistry World November 25, 2013 Carla Pegoraro	Steering cells towards biocomputers Bacterial toxins that undergo unique cell interactions have been used to perform logic functions by researchers in Germany. This innovation will help push the limits of synthetic biology.
Chemistry World April 14, 2011 Sarah Farley	Fish in chips: growing embryos in microfluidic systems Scientists in the Netherlands and the UK have shown for the first time that an animal embryo can develop in a microfluidic environment.
Chemistry World May 12, 2014 David Bradley	Elemental discoveries at the cellular level A combination of two high-power analytical techniques -- synchrotron radiation microscopy and atomic force microscopy -- has allowed Italy scientists to map vital elements in a single cancer cell.
Bio-IT World July 15, 2003	Millennium's PARIS Illuminates Pathways To address high-throughput-data challenges, Millennium Pharmaceuticals built the PAthway Resource and Information System, or PARIS -- a unique platform for combining knowledge from heterogeneous data sources in the construction of a pathway knowledgebase.
Chemistry World May 21, 2012 Simon Hadlington	Rewritable DNA for digital data storage A rewritable memory storage module can form the basis of a digital memory system, scientists suggest, with the cell being able to 'record' transient changes in its internal chemistry.
Chemistry World March 10, 2011 Elinor Richards	3D model to study breast cancer Scientists from the US have made a computational model of the formation of breast acini, the sac-like part of the milk-producing glands, to understand complex events occurring during the progression of breast cancer.
Chemistry World November 1, 2013 Megan Tyler	High-throughput chip for drug screening in 3D A simple micro-array chip developed by scientists in China could sharpen the search for new drugs by enabling the high-throughput screening of drug candidates against cells cultured in three dimensions.
HHMI Bulletin Aug 2011 Cassandra Willyard	A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice.
Chemistry World October 2, 2006 Bea Perks	RNAi Pioneers Win Nobel Prize for Medicine Molecular biologists Andrew Fire and Craig Mello have been awarded this year's Nobel prize in physiology or medicine for their discovery of RNA interference.
Bio-IT World November 12, 2002 James Golden	The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success.
Chemistry World May 5, 2011 Simon Hadlington	Revolutionary new single-cell labelling method Researchers in the US and Canada have combined mass spectrometry with a technique called flow cytometry to follow dozens of biochemical markers on individual cells simultaneously.
HHMI Bulletin Winter 2013 Amber Dance	A Trick of Light When miniSOG protein takes in blue light, it converts ordinary oxygen into a short-lived, excited state called singlet oxygen, which reacts with and changes the molecules around it. The singlet oxygen destroys the mitochondria's delicate machinery.
Bio-IT World December 15, 2004 David A. Bumcrot	Identifying RNAi Drug Candidates Breakthroughs in understanding RNA's extensive role in essential cellular processes have opened up the potential for a whole new class of drugs based on RNAi.
Bio-IT World July 15, 2003 Malorye Branca	Silence Is Golden RNA interference's scientific, therapeutic, and economic potential is unquestionable, but some sticky questions still remain.
Bio-IT World April 15, 2003 Malorye Branca	Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease?
Chemistry World April 20, 2009 James Urquhart	New method reveals small molecule-RNA conjugates US scientists using novel chemical screening methods have discovered a new class of small molecules connected to RNA, suggesting that cellular RNA may be more chemically diverse than previously thought.