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Chemistry World July 15, 2010 Simon Hadlington	Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.
Chemistry World April 7, 2008 Simon Hadlington	Polyketide ring mystery solved US researchers have worked out how some microbes produce polyketides - a class of polycyclic compounds that have antibiotic and anti-cancer properties but are difficult to manufacture.
Chemistry World August 11, 2008	Yeast Manufacture Morphine Precursor US scientists have developed a way to produce a group of medically important plant compounds in yeast. They say their technique could be used to manufacture drugs including painkillers and new cancer treatments.
Chemistry World October 29, 2009 Lewis Brindley	Cascading reactions in artificial cells Dutch researchers have started performing multi-step reactions inside artificial cells made from enzymes and polymers.
Chemistry World August 10, 2009 James Urquhart	Stretching for reversible enzyme activation A new kind of biologically inspired nanomaterial that can be chemically turned on and off by mechanical stretching has been devised by French researchers.
Chemistry World August 14, 2015 Emma Stoye	Biotech breakthrough as yeast makes painkillers from sugar The first strain of yeast that can synthesize painkilling opioids from scratch using a sugar feedstock has been engineered by scientists in the US.
Chemistry World November 3, 2014 Debbie Houghton	Engineered metalloenzyme catalyses Friedel -- Crafts reaction Reprogramming the genetic code of bacteria to incorporate an unnatural amino acid has allowed scientists in the Netherlands to create a new metalloenzyme capable of catalyzing an enantioselective reaction.
Chemistry World August 29, 2007 Ananyo Bhattacharya	'Lost' Folate Enzyme Found After 30 Years US researchers have revealed the identity of an enzyme used by bacteria to make the essential B vitamin folate, 30 years after it was first isolated.
Chemistry World September 24, 2013 Jennifer Newton	Plants and microorganisms are the original synthetic chemists Greg Challis is a professor of chemical biology at the University of Warwick in the UK. Research in the Challis group encompasses the discovery, biosynthesis, bioengineering and mechanism of action of bioactive natural products.
Chemistry World August 11, 2011 Hayley Birch	'Dial a Molecule' Approach Controls Antibiotic Production Scientists have used genetic methods to control the chemical structures of pacidamycin antibiotics produced in bacteria. Their approach allows them to 'dial into' particular molecules, and to generate new pacidamycins.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Food Processing August 2007 Mark Anthony	Nutrition Beyond the Trends: Connecting the Dots on Enzymes Lactase -- an enzyme that splits lactose into its constituent sugars, glucose and galactose -- can make short work of the lactose intolerance problem.
Chemistry World December 21, 2012 Laura Howes	Engineered enzyme performs cyclopropanation by carbene transfer While biomimetic chemistry has been busy learning from nature, other chemists have been busy modifying enzymes to develop biocatalysts for other reactions.
Chemistry World June 10, 2009 James Urquhart	Enzyme employs unusual cleavage reaction The mechanism of an unusual carbon bond cleavage reaction in the biosynthetic pathway of phosphinothricin tripeptide (PTT) - a naturally occurring herbicide and antibiotic compound - has been elucidated by US scientists
Chemistry World September 24, 2012 Samantha Cheung	Tumors reprogram nylon synthesis Cancer mutations have inspired a redesign of an enzyme to catalyze a key step in the bio-based production of adipic acid, a precursor to nylon.
Chemistry World February 17, 2013 Simon Hadlington	Enzyme nano-parcels sober up drunken mice Scientists in the US and China have invented a way to encapsulate teams of enzymes in a thin polymer shell. This enables the enzymes to carry out a series of sequential reactions within an enclosed space -- as happens in nature.
Chemistry World November 12, 2007 Simon Hadlington	Coupled Enzymes May Spawn New Catalysts Chemists at the University of Oxford have created a new type of catalyst by attaching two enzymes to a microscopic flake of graphite. The system could be tailored to catalyze a range of reactions, the researchers say.
Chemistry World September 19, 2008 John Bonner	Filling the antibiotic gap Resistance to currently available antibacterial drugs is causing growing concern among doctors who find themselves unable to treat common infections
Chemistry World May 1, 2014 James Urquhart	Ancient oceans' metals mimicked metabolism Primitive metabolism of sugar phosphates may have started spontaneously in ancient oceans around 4 billion years ago and given rise to life, according to UK researchers.
Chemistry World June 11, 2009 James Urquhart	Enzyme-free assembly of DNA-like molecules US scientists have developed a simple peptide nucleic acid system that self-assembles and adapts to new instructions without enzymes.
Chemistry World January 6, 2010 Phillip Broadwith	Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain.
Chemistry World October 2, 2013 Anthony King	Saving carbon to increase biofuel brewing efficiency Scientists in the US have designed a synthetic pathway for glycolysis that cuts carbon loss and could significantly boost production of biofuels and other chemicals in bio-refineries.
Chemistry World May 18, 2015 Simon Hadlington	Opiate-producing yeast raises specter of 'home-brewed heroin' Science policy experts have called for urgent measures to be put in place to prevent strains of yeast that are capable of producing opiate drugs from falling into the hands of criminals.
Chemistry World February 9, 2012 Jennifer Newton	A new generation of tuberculosis drugs Scientists in India are targeting enzymes responsible for catalysing the formation of bonds to repair nicks in the phosphodiester backbone of DNA - called DNA ligases - to tackle the ever-growing health concern of multi-drug resistant bacteria.
Chemistry World February 2011	Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
Chemistry World June 12, 2006 Katharine Sanderson	Similar Enzymes, Different Smells Petunia flowers and basil leaves use similar enzymes to give the plants their fragrance, say biologists. The enzymes also give spices, such as cloves and cinnamon, their spice.
Chemistry World January 18, 2009 Hayley Birch	Plants reprogrammed to produce potential drugs Plants could one day function as factories for producing anti-cancer drugs, say US scientists.
Chemistry World March 20, 2007 Tom Westgate	Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries.
IEEE Spectrum February 2009 Monica Heger	Computer-Designed Drugs Could Thwart Antibiotic-Resistant Bacteria Researchers use computer algorithms to tweak enzymes that make antibiotics
Chemistry World November 27, 2011 James Mitchell Crow	Artificial enzymes close in on nature A synthetic metalloprotein that approaches the catalytic performance of a natural enzyme, despite its stripped-down structure, has been developed by a team of chemists in the US.
Chemistry World November 26, 2012 Laura Howes	Protein coat prepares catalyst for cascades By protecting a transition metal catalyst with a protein coat, scientists have managed to couple up biocatalysts and chemical catalysts to perform a cascade reaction.
Chemistry World June 9, 2013 James Urquhart	Hairy proteins survive stomach trip Swiss researchers have discovered a way to stabilize enzymes in the digestive tract by linking polymers to the enzymes.
Chemistry World October 28, 2011 Laura Howes	Clicking Your Way to Synthetic Antibody Therapies Scientists have clicked together synthetic antibodies using the enzymes they want to target as a template. These synthetic antibodies can then be used to bind to the enzyme templates they were cast from, which could open up a whole new field of therapeutic molecules.
Chemistry World March 4, 2013 Harriet Brewerton	Co-factoring on a chip makes biocatalysis easy Stephan Mohr and colleagues have designed an efficient microfluidic biocatalysis device that uses and regenerates an artificial mediator, dimethyl viologen, which is cheaper than co-factors used currently.
Chemistry World March 8, 2007 Simon Hadlington	Researchers Claim Antibiotic Holy Grail Researchers in Canada have revealed the structure of a key enzyme involved in the synthesis of bacterial cell walls. The finding opens up the possibility of developing new and improved antibiotics and overcoming the increasing problem of bacterial resistance to existing drugs.
Chemistry World May 30, 2013 Andy Extance	Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity.
Chemistry World October 12, 2007 James Mitchell Crow	Flow Reactors Enter the Rapids Continuous flow chemistry's promise to shake up synthesis gathered momentum this month, with the first Uniqsis Flow Chemistry Symposium.
Chemistry World January 30, 2015 Debbie Houghton	Thin film approach to biocatalysis Taking an unconventional approach to biocatalysis has allowed scientists in Italy to improve enzyme recycling ability with a solvent-free reaction mixture
Chemistry World February 12, 2015 Andrew Turley	Enzyme uses internal network for cyclization Researchers have investigated the formation of cyclic terpenes in Artemisia annua, the plant source of antimalarial drug artemisinin, and found that a collection of amino acids working together as a network are likely to be responsible.
Chemistry World May 8, 2012 Phillip Broadwith	Keep stirring that Suzuki The shape of your reaction vessel can influence the behavior of organotrifluoroborate compounds in Suzuki cross-coupling reactions, say chemists in the UK.
Chemistry World February 21, 2008 Lewis Brindley	Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals.
Chemistry World October 21, 2010	Mining Soil DNA for Molecular Decorators US Researchers have harnessed enzymes hidden in the genomes of soil bacteria to modify a natural antibiotic molecule in ways that would be difficult or impossible by traditional synthesis.
Chemistry World June 17, 2010 Andrew Turley	Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy.
Chemistry World April 9, 2008 Henry Nicholls	How plants shudder at shade Scientists claim to have worked out how plants channel energy away from leaves and into spindly shoots, a natural but at-times infuriating response to a bit of shade. Plants are sensitive to the wavelength of light that's reaching them.
Chemistry World March 16, 2015 Elisabeth Ratcliffe	Enzyme selectivity switch to benefit infant formula production Scientists in Austria who have redesigned the active site of an enzyme to switch its regioselectivity may have latched onto a new way to make molecules that are important for infant formula.
Chemistry World October 31, 2013 Derek Lowe	Natural born chemists Organic chemists may not seem like a humble group. But we should be, because we are humiliated every hour of the day by what nature accomplishes through enzyme catalysis.
Chemistry World May 15, 2014 Jenifer Mizen	Freeze-dried cells make better biocatalysts A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses.
Chemistry World September 21, 2009 Hayley Birch	Enzymes inspire new catalyst design for hydrogen production A novel enzyme-based catalyst developed by UK and US researchers hints at new ways of designing catalysts for the water-gas shift reaction, an important industrial reaction in the production of high grade hydrogen.
Chemistry World January 28, 2014 Katia Moskvitch	Sweet success for bio-battery Rechargeable, energy-dense bio-batteries running on sugar might be powering our electronic gadgets in as little as three years, according to a US team of scientists.
Chemistry World December 12, 2006 Michael Gross	Ancient Protein Moonlights in the Eye A structural protein in the mouse eye lens is the evolutionary descendant of an ancient bacterial enzyme, researchers have found -- suggesting that moonlighting saved the protein from oblivion when its original role was taken over by a different family of enzymes.