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Chemistry World November 26, 2012 Laura Howes	Protein coat prepares catalyst for cascades By protecting a transition metal catalyst with a protein coat, scientists have managed to couple up biocatalysts and chemical catalysts to perform a cascade reaction.
Chemistry World March 6, 2008 Simon Hadlington	Synthetic Enzymes Designed by Computer Scientists in the US have designed and built an artificial enzyme from scratch.
Chemistry World January 6, 2010 Phillip Broadwith	Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain.
Chemistry World July 15, 2010 Simon Hadlington	Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.
Chemistry World September 24, 2007 Simon Hadlington	Viral Nanoreactor Captures Single Molecules Researchers in the Netherlands have created a biochemical nanoreactor by cracking open a virus, removing its contents then reassembling the virus's protein coat around a single molecule of enzyme.
Chemistry World January 17, 2014 Phillip Broadwith	Plug and play redox enzymes With the constant drive to make chemical synthesis ever cleaner, more energy-efficient and generate less waste -- both in research and industrial processes -- more and more chemists are looking to harness enzyme catalysis.
Chemistry World April 14, 2006 Simon Hadlington	Deciphering Hydrogen Tunnelling in Enzymes Researchers have thrown important new light on the phenomenon of hydrogen tunnelling in biological catalysts. The finding is likely to spark a debate among biochemists about the fundamental nature of enzymes.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World April 26, 2007 Richard Van Noorden	Hydrogen Busters go Synthetic Chemists have created a small molecule which mimics the way natural enzymes chew up hydrogen. The model should inspire designs for new catalysts that can break up hydrogen in fuel cells; or (running in reverse) help produce the fuel for a hydrogen economy.
Chemistry World November 12, 2007 Simon Hadlington	Coupled Enzymes May Spawn New Catalysts Chemists at the University of Oxford have created a new type of catalyst by attaching two enzymes to a microscopic flake of graphite. The system could be tailored to catalyze a range of reactions, the researchers say.
Chemistry World December 21, 2012 Laura Howes	Engineered enzyme performs cyclopropanation by carbene transfer While biomimetic chemistry has been busy learning from nature, other chemists have been busy modifying enzymes to develop biocatalysts for other reactions.
Chemistry World September 21, 2009 Hayley Birch	Enzymes inspire new catalyst design for hydrogen production A novel enzyme-based catalyst developed by UK and US researchers hints at new ways of designing catalysts for the water-gas shift reaction, an important industrial reaction in the production of high grade hydrogen.
Chemistry World July 25, 2008 Simon Hadlington	Structure of hydrogen splitting enzyme revealed Scientists in Germany have brought the prospect of generating cheap electricity from hydrogen a step closer by taking a snapshot of an elusive enzyme that can split the gas as efficiently as a platinum catalyst.
Chemistry World August 29, 2007 Ananyo Bhattacharya	'Lost' Folate Enzyme Found After 30 Years US researchers have revealed the identity of an enzyme used by bacteria to make the essential B vitamin folate, 30 years after it was first isolated.
Chemistry World February 2011	Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
Chemistry World October 28, 2011 Laura Howes	Clicking Your Way to Synthetic Antibody Therapies Scientists have clicked together synthetic antibodies using the enzymes they want to target as a template. These synthetic antibodies can then be used to bind to the enzyme templates they were cast from, which could open up a whole new field of therapeutic molecules.
Chemistry World October 27, 2006 Richard Van Noorden	Synthetic Origami Folds Like Natural Enzymes Researchers have synthesised a large organic molecule that folds up like a small protein, though its backbone is entirely non-biological. The achievement is a step along the path to producing truly synthetic enzymes in the laboratory.
Chemistry World October 29, 2009 Lewis Brindley	Cascading reactions in artificial cells Dutch researchers have started performing multi-step reactions inside artificial cells made from enzymes and polymers.
Chemistry World March 15, 2007 Henry Nicholls	The Mother of All Enzymes Scientists have uncovered the three-dimensional structure of what might be biology's first enzyme. This sheds light on the chemistry at a key moment in the origin of life, they argue.
Chemistry World August 26, 2008 Fred Campbell	High-throughput protein microarrays on the way A new method to rapidly generate protein microarrays has been developed by UK researchers at the University of Manchester.
Chemistry World December 12, 2006 Michael Gross	Ancient Protein Moonlights in the Eye A structural protein in the mouse eye lens is the evolutionary descendant of an ancient bacterial enzyme, researchers have found -- suggesting that moonlighting saved the protein from oblivion when its original role was taken over by a different family of enzymes.
Chemistry World March 4, 2013 Harriet Brewerton	Co-factoring on a chip makes biocatalysis easy Stephan Mohr and colleagues have designed an efficient microfluidic biocatalysis device that uses and regenerates an artificial mediator, dimethyl viologen, which is cheaper than co-factors used currently.
Chemistry World November 27, 2013 Jennifer Newton	A cytochrome from scratch Artificial proteins could be closer to participating in natural biochemical pathways after researchers show that bacteria will process amino acid sequences entirely unrelated to any natural protein to produce a fully functioning cytochrome.
Chemistry World October 17, 2011 Andy Extance	Water erodes 'lock and key' drug model US researchers have dealt a severe blow to the idea of a single 'hydrophobic effect' that can help explain how all drugs dock with proteins.
Chemistry World February 5, 2013 James Urquhart	Sea urchin inspires carbon capture catalyst UK scientists have taken inspiration from the sea urchin and shown how nickel nanoparticles could be a cheap and re-usable catalyst in a key step for capturing carbon dioxide produced by power plants and the chemical industry.
Chemistry World August 11, 2011 Josh Howgego	Enzyme Inspired Nickel Complex Races to Produce Hydrogen A cheap nickel catalyst could pave the way for the industrial production of hydrogen - a step on the road to a hydrogen economy.
Chemistry World February 25, 2014 Simon Hadlington	Synthetic 'textbook model' of a biological catalyst Scientists have developed a simple two-molecule chemical analogue of an enzyme and its substrate that neatly illustrates the fundamental principles of biological catalysis.
Chemistry World September 24, 2012 Samantha Cheung	Tumors reprogram nylon synthesis Cancer mutations have inspired a redesign of an enzyme to catalyze a key step in the bio-based production of adipic acid, a precursor to nylon.
Chemistry World November 14, 2013 James Urquhart	Mysterious selectivity of nature's blowtorches solved US researchers have solved the long-standing mystery of how cytochrome P450 enzymes generate intermediates to perform demanding oxidations of inert C -- H bonds without damaging their fragile protein network in the process.
Chemistry World May 2, 2007 Michael Gross	Protein Printboard Chemists in the Netherlands have created nanoscale structures that can immobilize proteins with exquisite control over specificity, strength and orientation.
Chemistry World March 8, 2007 Simon Hadlington	Researchers Claim Antibiotic Holy Grail Researchers in Canada have revealed the structure of a key enzyme involved in the synthesis of bacterial cell walls. The finding opens up the possibility of developing new and improved antibiotics and overcoming the increasing problem of bacterial resistance to existing drugs.
Chemistry World August 13, 2009 Simon Hadlington	Forcing enzyme activity New research has shown that physically stretching an enzyme can trigger its activity - even when the active site is not hidden in a 'cryptic' position. Mechanical force may play a more important role in biological molecular systems than previously realized.
Chemistry World March 16, 2015 Elisabeth Ratcliffe	Enzyme selectivity switch to benefit infant formula production Scientists in Austria who have redesigned the active site of an enzyme to switch its regioselectivity may have latched onto a new way to make molecules that are important for infant formula.
Chemistry World October 31, 2013 Derek Lowe	Natural born chemists Organic chemists may not seem like a humble group. But we should be, because we are humiliated every hour of the day by what nature accomplishes through enzyme catalysis.
Chemistry World November 12, 2009 Simon Hadlington	Carbonic acid captured Scientists from Germany and Israel have caught a fleeting glimpse of carbonic acid, the simple yet elusive molecule that plays a key role in nature.
Chemistry World April 21, 2010 Simon Hadlington	Methane oxidising enzyme mystery solved The finding could lead to a cost-effective and environmentally clean method of methanol production for fuel and feedstock.
Chemistry World April 2, 2009 Ned Stafford	Fluorescent probes take screening to next level Researchers have developed a new high-throughput screening technique that could shed light on the biochemical activities of numerous proteins about which little is currently known.
Chemistry World October 14, 2008 Simon Hadlington	Enzymes hit with double punch US chemists have made a small molecule that simultaneously blocks two key enzymes involved in the growth of cancer cells.
Chemistry World November 6, 2009 Phillip Broadwith	Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before.
Nutra Solutions October 10, 2007 Kerry Hughes	Products: The "Spark of Life" The potential for enzyme use has not escaped scientists' imaginations, as enzymes are used in numerous industrial and medical applications.
Chemistry World June 9, 2013 James Urquhart	Hairy proteins survive stomach trip Swiss researchers have discovered a way to stabilize enzymes in the digestive tract by linking polymers to the enzymes.
Chemistry World September 9, 2007 Simon Hadlington	Sugaring the Pill Researchers in the US have made a key advance in efforts to bolt sugar molecules onto natural products in the search for new drugs.
Chemistry World May 21, 2009 Simon Hadlington	Long-awaited structure of famous enzyme challenges the textbooks US researchers have uncovered a biochemical irony: a famous enzyme whose study led to some of the fundamental concepts of biological catalysis does not behave in the way that was previously thought.
Chemistry World August 5, 2010 Simon Hadlington	Nitrogenase found to be a two-trick pony An enzyme whose job is to convert nitrogen gas to ammonia - a process known as nitrogen fixation - can also reduce carbon monoxide US researchers have discovered.
Food Processing August 2007 Mark Anthony	Nutrition Beyond the Trends: Connecting the Dots on Enzymes Lactase -- an enzyme that splits lactose into its constituent sugars, glucose and galactose -- can make short work of the lactose intolerance problem.
Chemistry World October 31, 2008 Manisha Lalloo	DNA-rewinding protein discovered US scientists have found an enzyme that rewinds sections of DNA whose strands have mistakenly come apart.
Chemistry World January 19, 2007 Lionel Milgrom	Quantum Theory Reveals Why Lead Poisons Lead is one heavy metal. It can cause irreversible blood, brain, kidney, and liver damage. But why is it so toxic? Using quantum chemistry and enzyme model compounds, researchers now believe they have the answer.
Chemistry World June 23, 2015 Derek Lowe	Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example.
Chemistry World September 1, 2008 Hayley Birch	Cancer target structure unveiled Researchers in the US have produced the first detailed structure of a key protein involved in regulating cancer, an eagerly anticipated advance that should speed anti-cancer drug development.
HHMI Bulletin Winter 2013 Olga Kuchment	Rickety for a Reason Imagine walking inside a building so flimsy that it shakes with every step, making you wonder what keeps it standing. HHMI early career scientist Sin Urban has been asking the same question about an unusual class of enzymes, the rhomboid proteases.