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Bio-IT World Dec 2006/Jan 2007 John Russell |
Setting the Systems Bio Syllabus An interview with David de Graaf about Pfizer's growing comfort with systems biology. |
Bio-IT World February 2006 John Russell |
Marvelous Models of Biological Systems Here are highlights from a roundtable discussion with researchers representing academia and pharmaceuticals, as well as executives from modeling technology providers on whether or not Pharma is ready to bet on computational modeling of biological systems. |
Bio-IT World June 17, 2004 John Russell |
Systems Biology - Now Leaving on Track 1 Entelos, a leader in predictive biosimulation, partners with pharmaceutical and biotech organizations worldwide to develop effective new treatments for disease. Michael French, chief business officer at Entelos, explains what powers the systems biology engine. |
Bio-IT World March 8, 2005 John Russell |
Entelos' Lofty Aspirations This is an interesting period for systems biology's wing of predictive biology companies. The label's luster is fading, but buoyed by pharma's growing interest, they are trying to figure out how to grow. |
Bio-IT World September 2005 John Russell |
Labor Pains and Gains Labor Day is the starting gun for the bio-science industry's race through the next year. Here are some up-and-coming items to watch: Transparency... Systems Biology... Crawford and McClellan... |
Bio-IT World September 2006 John Russell |
Informatics Cornucopia Predictive Informatics, the hopeful title of a session at last month's Drug Discovery Technology & Development World Congress, remains an enticing but mostly elusive goal. Asked what systems biology would look in five years and what will constitute success, panelists offered the following. |
Bio-IT World November 12, 2002 Michael Goldman |
A Virtual Pharmacopeia Computational modeling of disease pathways, organs --- even patients --- could transform drug discovery. Does salvation exist in silico? |
Bio-IT World May 19, 2004 John Russell |
Seeing the Forest and the Trees A tiny clearing in the fog of systems biology. |
Bio-IT World October 2006 John Russell |
GNS Charts "Unknown" Biology Gene Network Sciences' CEO and colleagues now think they have the right tool to mine the treasure trove of unknown biology hidden in the wealth of accumulating omic data. |
Bio-IT World Dec 2006/Jan 2007 John Russell |
Novartis' Answer to Harry Potter Imagine a magic wand able to instantly materialize novel, safe, and effective drugs. No such device exists, of course, but Novartis has a distant cousin of sorts: the UltraLink is an immensely powerful text-mining tool and knowledge management platform. |
Bio-IT World October 14, 2004 |
Deciphering Genstruct If you divide the systems biology world into two broad camps, wet-lab-focused data generators and in silico model makers, Genstruct is a modeler with a twist. |
Bio-IT World February 10, 2003 Salvatore Salamone |
Made in Manhattan A talk with the new head of the Computational Biology Center at Memorial Sloan-Kettering. |
Bio-IT World May 9, 2003 Michael Greeley |
Mechanistic Models Investors are backing predictive modeling software that could speed drug development. |
Bio-IT World December 15, 2003 Zachary Zimmerman |
Learning the Language of Systems Biology Geneticist par excellence David Botstein talks about his philosophy, science, his mission for integrative science, and what he deems a success for systems biology. |
Bio-IT World February 2006 John Russell |
Preventable Vioxx Problems? Pathway analysis tools might have identified Vioxx's problematic off-target activity much earlier. Wondering which modeling approach to use for your project? |
Bio-IT World March 2007 John Russell |
In Search of Spring Tired of winter? Here are some signs of spring for systems biology acceptance and a preview of Cambridge Healthtech's June conference, Applying Systems Biology, to whet your appetite for summer: 1. FDA Survey... etc. |
Bio-IT World November 2006 John Russell |
Pathway Pioneers Innovative uses for pathway tools and exciting results from early users are sprouting like mushrooms after a spring rain -- albeit following a few harsh winters. And the usually risk-averse pharmaceutical industry has led in adopting pathway tools. |
Bio-IT World June 12, 2002 John Dodge |
All Systems Go at ISB The Seattle-based Institute for Systems Biology (ISB), takes a holistic view of genomic and proteomic research. The author spoke with its president, noted biologist Leroy Hood, recently to find out how far ISB has come in its two years of life. |
HHMI Bulletin Nov 2011 Sarah C.P. Williams. |
Carolyn Bertozzi: Changed Expectations Chemists trained in biology were once a rarity -- now they're becoming the norm. |
Bio-IT World January 21, 2005 |
Defining 'Integrative Genomics' Five experts from academia and industry discuss the burgeoning field of integrative genomics. |
Bio-IT World December 15, 2003 Mark D. Uehling |
Model Patient Despite the FDA's new support for computational modeling, the pharmaceutical industry remains cautious about simulating clinical trials. |
Bio-IT World Jul/Aug 2006 John Russell |
MathWorks Launches a 'Systems Biology' Tool The maker of the popular MATLAB programming environment recently launched a modeling product, SimBiology, aimed at systems biology and synthetic biology markets. |
Pharmaceutical Executive October 1, 2011 Atsushi Nagahisa |
Creating Customer Value: It's No Distant Dream The author speaks about how the pharmaceutical industry can fix today's greatest global policy challenge: leveraging hard science to address an enormous -- and growing -- burden of unmet medical need. |
Bio-IT World August 18, 2004 Mark D. Uehling |
I, Virtual Patient Along with a software company specializing in modeling diseases on the computer, Roche Diagnostics is working on creating a new biomarker for diabetes that could be reduced to a simple blood test. |
Bio-IT World March 2006 John Russell |
It's All About the Drugs A conversation with biopharma Organon's executive VP for global research and development highlights how, regardless of the company's enthusiasm for new technology, it is first and foremost interested in pharmacology and medicinal chemistry -- drugs. |
Bio-IT World August 2005 John Russell |
Pfizer's Model of Success Pfizer Global Research & Development began using sophisticated modeling technology and collaboration software to speed its race to a go-no-go decision on a cholesterol-lowering drug project. Killing the project sooner saved up to $2.8 million in costs and six months in delay. |
Chemistry World September 13, 2012 Andy Merritt |
Chemical biology comes of age Historically strongest in the US, chemical biology has become increasingly important worldwide, but for many years researchers at the chemistry -- biology interface have struggled to establish their discipline |
Bio-IT World October 2005 John Russell |
Compugen Transforms Its Business Many informatics pioneers discovered the hard way that selling software licenses and fee-for-services can't always pay the bills. Tel Aviv-based Compugen, is working to reinvent itself as a drug discovery and development player. |
Bio-IT World July 14, 2004 Malorye A. Branca |
The Pathways Promise By using the right tools, even a modest genomic data set can generate a good view into a particular biological pathway. Now, a range of new technologies is arising from academia as well as the commercial sector to meet this need. |
Bio-IT World September 2006 Nat Goodman |
Getting a Handle on Systems Biology Systems biology is squarely an experimental field that eats, drinks, and breathes data. To do systems biology, you need an experimental system that is amenable to large-scale experimentation. |
Bio-IT World January 12, 2004 Julia Boguslavsky |
New Year Tools for the 'New' Biology Instrumentation outlook for systems biology. |
Bio-IT World Dec 2006/Jan 2007 |
Resolute in the New Year Industry leaders in areas from pharmacogenetics to cheminformatics found 2006 to be a year of important steps forward, but looked with even more anticipation to 2007: Allen D. Roses, SVP, Pharmacogenetics GlaxoSmithKline... etc. |
Bio-IT World Dec 2006/Jan 2007 Giacomo Bastianelli |
The Future of Predictive Biology Predictive biology, data and the integration of disparate research disciplines are key ingredients for the future of drug discovery research and healthcare. |
Bio-IT World July 11, 2002 Mike Fitzgerald |
Funding the Future Investor G. Steven Burrill, CEO of Burrill & Company, helps biotech companies fulfill their potential. He talked recently about his view of the bio-IT field. |
Chemistry World May 1, 2014 Ned Stafford |
Synthetic biology vision for Europe unveiled A new 'strategic vision' for synthetic biology has laid out the steps Europe needs to take in the next five to 10 year to nurture the field, with chemistry a key part of its strategy. |
Bio-IT World March 17, 2004 |
Systems Biology: Top-Down or Bottom-Up? Systems biology involves the representation and analysis of an intact biological system. Like many of the technological developments over the past 20 years, such as genomics, proteomics, combinatorial chemistry, and bioinformatics, pharma and medical communities hold high hopes that systems biology will help move molecular research closer to the practice of medicine. |
Bio-IT World April 2007 John Russell |
Toward a Cancer Interactome Researchers at the Center for Cancer Systems Biology are working toward identifying the high level wiring diagram for cancer. In this instance, that means an accurate map of all cancer-associated protein-protein interactions. |
Bio-IT World March 17, 2004 |
Pharma's Genomic Harvest How Pfizer plans to meet its goal of 20 new drug applications by 2006. |
Chemistry World January 2012 |
Cultivating collaboration A new network aims to bring the power of interdisciplinary innovation to bear on global food issues. |
Knowledge@Wharton |
A New Approach to Valuing Biotech Stocks Enormous swings in biotechnology stock prices during the last few weeks show how difficult it is for investors to value biotech companies. It's important to understand the invisible potential locked up in the organizational structure of biotechnology companies... |
Bio-IT World May 2006 Kevin Davies |
Trailblazers Test Public Markets Three companies in postgenomic fields are going public. Infinity Pharmaceuticals, Perlegen Sciences, and Entelos announced they would be entering the public markets by means of merger, IPO, and institutional offering. |
Bio-IT World January 21, 2005 Salvatore Salamone |
A Prescription for Information-Based Medicine TurboWorx president and CEO Jeff Augen not only combines computational and biology expertise, but also has a clear vision of how to advance life science discovery. |
Chemistry World |
Fishing for Chemical Answers to Biological Questions James K. Chen talks about chemical biology, his love for the outdoors and fly fishing. |
Bio-IT World January 13, 2003 John Dodge |
Talent Fuels Drug Pipeline in Swiss Time The functional genomics group has emerged as a critical link in the drug discovery chain at Novartis Pharmaceuticals Corp. While it employs a multidisciplinary approach to drug discovery, the four-year-old group's goals could not be simpler: Find novel drug targets. |
Bio-IT World January 21, 2005 |
Best Practices 2005: Strut Your Stuff Organizations are invited to strut their stuff for Bio*IT World's annual awards program. |
Bio-IT World July 2005 John Russell |
Harvard Tackles Systems Biology Towards the end of this summer, researchers at the Virtual Cell Program expect to unleash b -- pronounced "little b" -- a new open-source computer language they hope will energize the biological modeling community as nothing has before. |
Bio-IT World August 15, 2005 Kevin Davies |
Hood Hails 'Century of Biology' Leroy Hood won the 2005 Bio-IT World President's Award for his work on the synthesis of DNA and protein, and on the genome project. |
Bio-IT World Dec 2005/Jan 2006 John Russell |
GeneGo's Pathway to Profits Steady growth in literature citations plus several major pharmaceutical deals and now a recent FDA commitment suggest pathway technology is gaining sufficient credibility and the furthest along commercially of all the systems biology niches. |
Bio-IT World August 18, 2004 |
Project Summaries Drug Discovery and Development: Ace BioSciences... Compugen... Entelos/Organon... Iconix Pharmaceuticals... Johnson & Johnson Pharmaceutical Research & Development... Laboratoire Kastler Brossel ... etc. |
Bio-IT World May 2006 John Russell |
Kurzweil: Life Is the Fast Lane Inventor and futurist Ray Kurzweil's opening keynote at the Bio-IT World Life Sciences Conference + Expo painted an optimistic vision of a world governed by growing information technologies that will transform what it means to be human. |