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Bio-IT World September 11, 2003 Mark D. Uehling |
Fishing Chips The next generation of protein microarrays from the likes of Protometrix and Molecular Staging may threaten the early leads of Biacore and Ciphergen -- and work so well that drug companies won't want them. |
Bio-IT World August 13, 2002 Malorye Branca |
The Proteomics Odyssey Efforts to map the constellation of protein interactions in humans gather momentum as companies vie to provide tools to capitalize on the potential of proteomics. But can proteomics prevail where some feel genomics has failed? |
Chemistry World January 11, 2008 John Bonner |
DNA Nanoparticles Detect Gene Expression US scientists have made nanoparticles from DNA that they say could be used to identify the genes being expressed in a single cell. |
Bio-IT World August 15, 2005 Robert M. Frederickson |
What's 'Post' About Postgenomic? Bioinformatics tools can help organize and study genomic sequences that were discovered in the '90s. The tools help with tasks like analyzing gene expression, predicting protein structure and function, and establishing networks of interacting protein in cells. |
Chemistry World December 12, 2011 Simon Hadlington |
Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity. |
HHMI Bulletin Feb 2011 |
DNA Curtains How proteins behave in such a crash test gives scientists data about their structural integrity, how they attach to DNA, and how they behave in a cell. |
Bio-IT World April 16, 2004 Robert Frederickson |
Trial Separations Protein separation through the digital ProteomeChip microchip takes merely minutes, resulting in significantly increased productivity. |
Industrial Physicist Aug/Sep 2003 Ineke Malsch |
Protein research calls for advanced instruments The science of protein interactions is becoming a major tool in biomedical and drug development research. Carrying out and advancing such studies more efficiently and effectively, however, will require new, cutting-edge instrumentation. |
Technology Research News March 24, 2004 |
DNA has nano building in hand Researchers from Ludwig Maximilians University in Germany have built a simple molecular machine from DNA that can bind to and release single molecules of a specific type of protein. |
Technology Research News September 24, 2003 Kimberly Patch |
Heated plastic holds proteins One important task for biochips is sorting proteins, but it's tricky business getting protein molecules to be where you want them and stay away from where you don't. A tiny, plastic-coated hot plate allows scientists to trap and release proteins on command. |
Bio-IT World July 2005 Robert M. Frederickson |
Amassing Mass Spectrometry Tools Mass spectrometry is a key tool in the effort to identify protein biomarkers of human disease. Manufacturers have met major challenges in adapting this technology to protein discovery, both qualitatively and quantitatively. |
Bio-IT World July 15, 2003 Julia Boguslavsky |
'Fingerprinting' a Single Cell Single-cell proteomics is finally within reach, thanks to a professor of analytical chemistry. |
Chemistry World August 26, 2008 Fred Campbell |
High-throughput protein microarrays on the way A new method to rapidly generate protein microarrays has been developed by UK researchers at the University of Manchester. |
Technology Research News January 14, 2004 |
Wet biochip preserves proteins Researchers from Kyushu University in Japan have produced a hydrogel material that makes it possible for proteins to survive aboard labs-on-a-chip. |
PC Magazine July 13, 2005 John R. Quain |
DNA Printing Press A group of scientists believes it has an inexpensive nanoprinting technique that could lead to the mass production of DNA-based chips that could revolutionize disease detection. |
Bio-IT World February 10, 2003 Robert M. Frederickson |
Bringing Integrated Circuits to Life Cell-sized biochips mean that channels, pumps, and valves must become minuscule, too. |
Chemistry World October 31, 2008 Manisha Lalloo |
DNA-rewinding protein discovered US scientists have found an enzyme that rewinds sections of DNA whose strands have mistakenly come apart. |
The Motley Fool February 28, 2011 Brian D. Pacampara |
Next-Generation Drug Technologies Battle It Out Alnylam and Sangamo BioSciences have different ways to manipulate proteins to fight disease. |
Technology Research News December 11, 2002 Kimberly Patch |
DNA prefers diamond DNA is particularly useful for sensing pathogens like those used in biological weapons. The trick to making sensors that can be used in the field may involve attaching strands of DNA to a thin film of diamond, preparing sensors to withstand the rigors of the real world. |
HHMI Bulletin February 2011 Michele Solis |
Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time. |
Bio-IT World April 15, 2003 Malorye Branca |
Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease? |
Salon.com May 1, 2000 Arthur Allen |
Listening to DNA The genome project is getting the buzz. But the real breakthroughs may come from labs out of the limelight, like Gene Logic. |
Chemistry World July 21, 2011 James Mitchell Crow |
Sequencing Chip Decodes DNA Proton by Proton Technology that can directly detect the chemical reaction as a single nucleotide adds to the end of a growing strand of DNA is about to slash the cost of genome sequencing, its inventors say. |
Chemistry World August 24, 2009 Phillip Broadwith |
'Chemical nose' sensor sniffs blood protein profile US scientists have developed a sensor system for profiling the protein content of human blood serum without needing individual receptors for each separate protein. |
IEEE Spectrum March 2011 Lucks & Arkin |
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering |
Chemistry World June 14, 2011 |
A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR. |
Technology Research News December 3, 2003 Kimberly Patch |
DNA assembles nanotube transistor Scientists have caused a transistor to self-assemble from a test tube concoction of DNA, proteins, antibodies, carbon nanotubes and minuscule specks of silver and gold. The feat shows that it is possible to assemble the smallest of machines and electronic devices by harnessing DNA's properties. |
Chemistry World April 27, 2006 |
`Sticky Trees' Glue Molecules to Proteins Researchers have developed a chemical glue that binds molecules to proteins without compromising protein function. The method could be used to modify a wide range of proteins for a variety of purposes, such as in the development of new protein-based therapies. |
Reactive Reports Issue 51 David Bradley |
Protein Crystals Trapped Researchers have developed a new technique for crystallizing proteins, which could open up a whole range of materials to this powerful analytical technique. |
Bio-IT World September 2006 Robert M. Frederickson |
Assays and Knowledgebases for Genomic Analysis An important aspect of any genomic analysis -- whether expression profiling or analysis of DNA-binding elements as above -- is the integration of the data with existing knowledge. |
HHMI Bulletin February 2012 Sarah C.P. Williams |
The Twists and Turns of Immunity Fred Alt has built a career making sense of the immune system -- specifically, the diverse antibodies that fight off invading molecules, from viruses to cancer cells to pollen. |
Bio-IT World January 21, 2005 Robert M. Frederickson |
High-Throughput Science Although genomic assays led the charge toward high-throughput science, new detection systems and formats are enabling the application of high-throughput techniques to proteins and cells. |
Chemistry World January 31, 2008 John Bonner |
RNAi Scores Victory Against Crohn's Disease in Mice Thousands of people suffering from the debilitating gut condition Crohn's disease could experience relief from their symptoms through a technique that blocks production of a key protein in the inflammation process. |
The Motley Fool July 26, 2007 Brian Orelli |
Affymetrix Advances New products and services should help Affymetrix regain market share. Yesterday, the company even announced a small second-quarter profit. |
Bio-IT World Jul/Aug 2006 Deb Janssen |
Managing the Microarray Data Mountain Genomic studies often involve thousands of samples and require hundreds of thousands of assays per sample. Microarray manufacturers are scurrying to satisfy researcher demands for increased array density, sample number, and content flexibility. |
Bio-IT World July 11, 2002 Malorye Branca |
Deep Sequence Diving Like sailors of old, genomic data miners dream of discovering riches and fame. Given the recent improvements in analytics -- and a little more time -- they just might succeed. |
Chemistry World June 25, 2012 Simon Hadlington |
Bloody Solution to Electrochemical DNA Sensors US researchers have discovered a way to significantly improve the sensitivity of DNA-based electrochemical sensors by incorporating an inexpensive, robust and stable protein into the system - haemoglobin. |
Bio-IT World May 19, 2004 Malorye Branca |
Attack of the Lab-Bots Robots are invading every aspect of discovery and development within pharmaceutical companies, from genotyping to high-throughput screening. |
Industrial Physicist Jennifer Ouellette |
Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems |
Chemistry World December 23, 2015 |
Bones of contention Can protein in dinosaur bones survive for millions of years? Rachel Brazil explores the evidence. |
Reactive Reports Issue 41 David Bradley |
Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip. |
Industrial Physicist |
Biomimetic Nanotechnology Although biomimetic nanotechnology is in its infancy, with no applications yet reaching commercialization, the barriers in some cases lie mainly in scaling up production processes to industrial levels. |
Chemistry World December 16, 2013 Michael Parkin |
1024 samples analysed on a single chip Researchers in Switzerland have developed a microfluidic platform able to measure four protein biomarkers in over 1000 blood samples on a single microfluidic chip. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
Chemistry World September 17, 2012 Ian Le Guillou |
Raising the curtain on single-stranded DNA Scientists have created microfluidic devices containing single-stranded DNA 'curtains' for the first time, allowing scientists to study its interactions with proteins in real time. |
Bio-IT World February 18, 2004 |
Proteomics Goes Cellular Tissue microarrays save big on sample material and reagents. But more importantly, this new high-throughput technology is helping save the lives of cancer patients |
Technology Research News January 12, 2005 |
Silicon Surfaces Speed Circuits Researchers have devised a way to use the chemistry of silicon surfaces to make smaller chip features. |
HHMI Bulletin Spring 2013 Sarah C.P. Williams |
Sounding the Alarm Details on how cells detect and respond to foreign DNA may provide clues to autoimmune diseases. |
Chemistry World February 2011 |
Idle cures Taking a coffee break could help find cures for cancer or Aids. Katrina Megget looks at the future of research that harnesses the computing power of the World Community Grid |
Chemistry World February 2012 |
Column: The crucible To understand the chemical choreography of the cell, we must acknowledge the bustling biomolecular ballroom in which it takes place, says Philip Ball |