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Chemistry World August 30, 2009 Phillip Broadwith	C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules.
Chemistry World April 2010 Paul Docherty	Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance.
Chemistry World February 2012 Paul Docherty	Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities.
Chemistry World November 5, 2013 Paul Docherty	Marcfortines B & C Natural product isolation is generally a tale of a journey to an obscure or inaccessible location, followed by pulping a harmless plant or marine sponge to get at compounds made by some bacteria hiding out in the core.
Chemistry World April 14, 2009 Lewis Brindley	Osmium and pyridine ring together Organic chemists in China have found a way to put osmium into a pyridine ring - leading to the synthesis of the first metallapyridinium complex.
Chemistry World March 2012 Paul Docherty	Column: Totally Synthetic Ring strain is a fascinating phenomenon - one that is best understood with plastic modelling kits, wearing safety specs for ring sizes of four or less.
Chemistry World October 2010 Paul Docherty	Barekoxide and barekol Like most scientists, organic chemists can often obsess about a problem, endlessly pursuing the perfect yield or enantioselectivity, often leading to tears and broken glassware.
Chemistry World January 28, 2015	Rubriflordilactone A It's likely that organic chemists have been practicing retrosynthesis in one form or another for at least a century, and certainly for decades before E J Corey formalized the concept in the mid-1990s
Chemistry World May 29, 2013 Paul Docherty	Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile.
Chemistry World July 2010 Paul Docherty	Column: Totally Synthetic Isolated in 1986, the steroid family of aplykurodinones have shown selective cytotoxicity in a variety of cancer cell lines, and add to the phenomenal list of steroids with potent medicinal properties.
Chemistry World August 2011 Paul Docherty	Column: Totally Synthetic Yuanhuapin, a fabulously complex member of the daphnane diterpene orthoester class of natural products, bears an astonishing twelve contiguous stereogenic centres around its seven rings (look closely!).
Chemistry World January 2, 2013 Paul Docherty	Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids.
Chemistry World November 2011 Paul Docherty	Column: Totally Synthetic Gelsemoxonine has an extra four-membered azetidine ring, making for a considerable synthetic challenge.
Chemistry World June 27, 2013 Paul Docherty	Bolivianine The still-growing and insanely diverse class of terpene natural products is probably responsible for a considerable number of undergraduate headaches.
Chemistry World April 2012 Paul Docherty	Column: Totally Synthetic Detecting rearrangements still seems like an abstract ability for aspiring synthetic chemists. Erick Carreira's synthesis of indoxamycin B is a great case in point, employing two rearrangement reactions.
Chemistry World November 2, 2015	Batzelladine B Of all the diverse substances that nature produces, the alkaloids -- small molecules containing basic nitrogen -- have had the greatest impact on human history and health.
Chemistry World June 2009 Paul Docherty	Column: Totally Synthetic With potent bacteria-beating activity, it's no surprise that kendomycin has recently grabbed quite a bit of attention.
Chemistry World February 2009 Paul Docherty	Column: Totally Synthetic The farming squeeze has renewed interest in compounds with anti-insect abilities, especially those known for their activity against specific pests.
Chemistry World March 2011 Paul Docherty	Column: Totally Synthetic Discovered independently by two chemists in the 1870s, it's remarkable that 140 years later, science is still tweaking and improving the aldol reaction.
Chemistry World June 2010 Paul Docherty	Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups.
Chemistry World June 1, 2012 Paul Docherty	atrop-Abyssomicin C This member of the abyssomicin family is the only one to achieve bacteria-bashing prowess, and is also the only one to feature atropisomerism -- a relatively unusual form of stereoisomerism in naturally occurring species
Chemistry World June 25, 2008 Lewis Brindley	Slick synthesis to sea sponge structure Chemists in the US have devised a new route to (-)-cyanthiwigin F, a complex biomolecule active against tumors
Chemistry World August 16, 2009 Tom Bond	Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.
Chemistry World January 29, 2014	Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family.
Chemistry World September 2010 Paul Docherty	Column: Totally Synthetic After a target has been synthesised, and the question of 'can we make this?' has been answered, perhaps the most important remaining question is 'how did nature make it?'
Chemistry World October 1, 2012 Paul Docherty	Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.
Chemistry World October 31, 2012 Paul Docherty	Epicoccin G The class of natural products known as 2,5-diketopiperazines is both broad and synthetically well-trodden. An important sub-class of these targets are found with a sprinkling of sulfur atoms, and seem particularly well-suited to pathogen-bashing.
Chemistry World August 29, 2012 Paul Docherty	Amphidinolide F We're plunging into the marine depths to find natural products with prodigious biological activity. The amphidinolide family comprises over 30 members, varying in architecture but (almost) all featuring a complex and highly decorated macrolactone ring at the core.
Chemistry World June 2011	Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.
Chemistry World January 2010 Paul Docherty	Column: Totally Synthetic Of all the natural product classes, the steroid family are perhaps the most prevalent in the public consciousness; from cholesterol to testosterone, their infamy inflates the 'science bit' in countless advertisements.
Chemistry World September 2, 2013 Paul Docherty	Steviol A discussion is presented on new ways to synthesize the diterpenoid steviol.
Chemistry World September 4, 2008 Fred Campbell	Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.
Chemistry World April 2009 Paul Docherty	Column: Totally Synthetic Perhaps the most frustrating part of being a synthetic chemist is the jealousy with which we must regard nature
Chemistry World December 2010 Paul Docherty	Column: Totally Synthetic In a conversation at the beginning of this year, a friend and I considered the most challenging targets available to the total-synthesizer - and maoecrystal V was at the top of the list.
Chemistry World February 22, 2008 James Mitchell Crow	Rhodium Fast Tracks Route to Lactones Chemists in Canada have developed an efficient new way to make lactones, chemical components of many natural products and drugs.
Chemistry World November 27, 2009 Simon Hadlington	A simple way to join an olefin to an arene Chemists in the US have developed a simple and effective way to carry out a key class of reaction in organic synthesis - the bolting an olefin to an aromatic ring.
Chemistry World September 20, 2007 Lewis Brindley	New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.
Chemistry World September 2009 Paul Docherty	Column: Totally Synthetic Maduropeptin chromophore (the active component of a chromopore-protein complex, noted as for its potent antitumor and antibiotic activity) is built of two distinct domains
Chemistry World July 1, 2012 Paul Docherty	Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity.
Chemistry World August 2008 Paul Docherty	Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses.
Chemistry World May 2011 Paul Docherty	Column: Totally Synthetic The ability to understand molecular structure is perhaps both our greatest skill and largest encumbrance as scientists. A quick glance at the structure of a target such as nanolobatolide tells us much about its connectivity and the manner in which it might react.
Chemistry World December 2008 Paul Docherty	Column: Totally Synthetic Pseudolaric acid B: regular readers of this column's online incarnation will have noticed that this is the second appearance for this particular synthesis.
Chemistry World July 2009 Paul Docherty	Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target.
Chemistry World November 27, 2012 Paul Docherty	Pentalenolactone A methyl ester One team that really gets the Pauson -- Khand reaction or the PKR and all its nuances is that led by Zhen Yang at Peking University in Beijing, China. They recently published a very neat synthesis of the intricate pentalenolactone
Chemistry World November 2010 Paul Docherty	Column: Totally Synthetic Perhaps the most familiar (and dull - they do say that familiarity breeds contempt.) chemical reaction to medicinal chemists is the amide bond formation.
Chemistry World November 27, 2008 Lewis Brindley	Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.
Chemistry World May 8, 2014	Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry.
Chemistry World September 2008 Paul Docherty	Column: Totally Synthetic The need to discover new antibiotics to treat resistant strains of bacteria is a well- documented and discussed challenge for chemists.
Chemistry World November 3, 2008 Simon Hadlington	Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?
Chemistry World October 2008 Paul Docherty	Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential.