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Chemistry World November 1, 2007 Richard Van Noorden |
Step Change for Organic Synthesis US chemists discovered how to attack a complex molecule's unreactive carbon-hydrogen bonds, without resorting to wasteful synthetic aids like protecting and directing groups. |
Chemistry World August 30, 2009 Phillip Broadwith |
C-H oxidation proves its worth US researchers are going against the grain of total synthesis and developing new approaches to complex molecules. |
Chemistry World July 9, 2012 Phillip Broadwith |
'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom. |
Chemistry World February 22, 2008 James Mitchell Crow |
Rhodium Fast Tracks Route to Lactones Chemists in Canada have developed an efficient new way to make lactones, chemical components of many natural products and drugs. |
Chemistry World November 27, 2009 Simon Hadlington |
A simple way to join an olefin to an arene Chemists in the US have developed a simple and effective way to carry out a key class of reaction in organic synthesis - the bolting an olefin to an aromatic ring. |
Chemistry World July 16, 2009 Simon Hadlington |
Strange vibrations Researchers in Taiwan have shown that in a relatively simple molecular system the induced vibrations can inhibit the breaking of the bond and slow the reaction down. |
Chemistry World January 2012 Paul Docherty |
Column: Totally Synthetic What a Japanese team demonstrates in this synthesis of dragmacidin D is the state of the art, uniting all the key fragments using C-H bond couplings. |
Chemistry World February 20, 2012 James Urquhart |
Unusual kinetics of catalyst revealed US researchers have elucidated the unusual reaction kinetics of C-H activation by the palladium(II) catalyst (Pd(OAc) 2). |
Chemistry World January 27, 2010 Phillip Broadwith |
Cracking carbon-carbon bonds Chemists in the US have discovered a tungsten complex that can break a strong carbon-carbon bond in an aromatic ring. |
Chemistry World June 23, 2011 Simon Hadlington |
Breaking the carbon-fluorine bond US chemists have discovered a new way to break the bond between carbon and fluorine atoms - the strongest carbon bond there is. |
Chemistry World March 21, 2007 Richard Van Noorden |
Forcing a Reaction US chemists have forced molecules to react by ripping their bonds apart with ultrasound. The scientists carefully stretched one targeted bond until it snapped, guiding the molecule's subsequent reaction into pathways forbidden by conventional chemistry. |
Chemistry World March 21, 2007 Alison Stoddart |
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. |
Chemistry World July 11, 2010 Simon Hadlington |
Elusive terminal uranium nitride found The compound is important because its ceramic state, uranium mononitride, is a candidate for nuclear fuels of the future. |
Chemistry World January 8, 2014 Karl Collins |
Oxidation station Small molecules are making significant inroads -- with reactivity and selectivity approaching levels previously thought unachievable. |
Chemistry World October 12, 2011 Joanne Thomson |
Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry. |
Chemistry World September 14, 2011 Simon Hadlington |
World's Longest Carbon-Carbon Bond Created Harnessing both attractive and repulsive forces enabled chemists to make a carbon-carbon bond 30 per cent long than normal. |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. |
Chemistry World March 31, 2009 Lewis Brindley |
Giving molecules a stretch A simple way to stretch small molecules and measure the forces at play has been developed by researchers in the US. |
Chemistry World July 29, 2010 Carol Stanier |
Methane all lined up Swiss researchers have found that the way methane molecules vibrate when they hit a nickel surface can have a huge effect on their reactivity. |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? |
Chemistry World February 2010 Paul Docherty |
Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World April 11, 2014 |
The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers |
Chemistry World December 13, 2009 Lewis Brindley |
Breaking the strongest bonds Chemists have uncovered a way to sever two of the strongest bonds in chemistry - in dinitrogen and carbon monoxide - and make useful organic compounds. |
Chemistry World January 29, 2012 Andy Extance |
Calculations reveal carbon-carbon quadruple bond C 2's two carbon atoms aren't joined by a double bond as usually thought, or even a triple bond, but in fact a quadruple bond. |
Chemistry World June 2, 2011 James Urquhart |
Methane activation by organometallic reagent US scientists have demonstrated for the first time that a metal-carbon multiple bond complex can activate methane. |
Chemistry World February 28, 2008 James Mitchell Crow |
Chloride Ions in a Bind Chemists in the US have designed a donut-shaped molecule that tightly binds negatively-charged chloride ions. |
Chemistry World March 9, 2006 Katharine Sanderson |
Covalent Bonds Crack Under the Strain Chemists must consider engineering principles when designing molecules following news that tough carbon-to-carbon bonds break easily under mechanical strain. |
Chemistry World November 18, 2012 Simon Hadlington |
C-O bond stretched to record length Chemists in the US have stretched the C-O bond to a record length, an 'extraordinary' 1.622 angstroms, compared with a typical length of around 1.43 angstroms in ethers. |
Chemistry World September 12, 2010 Simon Hadlington |
Isotope effect seen on single molecule The isotope effect - where the rate of a reaction is altered depending on the presence of a given isotopic atom in the reactant - is a key tool for elucidating reaction mechanisms |
Chemistry World June 13, 2012 Simon Hadlington |
Exploding molecule provides 3D bond images Researchers from the US and Germany have demonstrated a new way to obtain accurate three-dimensional images of molecules, with precise measurements of the geometry of the molecule's chemical bonds. |
Chemistry World August 15, 2011 Simon Hadlington |
Trifluoromethylation Made Easy US researchers have discovered a simple, low-cost way to add fluorine atoms to heteroaromatic rings. |
Chemistry World May 2009 Paul Docherty |
Column: Totally Synthetic After a glorious 1980s and 90s as the pin-ups of total synthesis, it seems that the macrolides are now passe, and all the cool kids have moved on to work on alkaloid natural products |
Chemistry World September 13, 2012 Philip Ball |
Bright idea to probe bond order The order of multiple bonds can be uncovered using atomic force microscopy, according to Leo Gross of IBM Research in Zurich and his co-workers. |
Chemistry World March 25, 2012 Phillip Broadwith |
Germanium-Oxygen Double Bond Takes Centre Stage The first compound with a germanium-oxygen double bond has been created by Japanese scientists. |
AskMen.com Michael Estrin |
Investing In Bonds Having some bonds in your portfolio is not only a good way to make money, it's also a great way to diversify. Here's what you need to know before you invest in the bond market. |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug |
Chemistry World January 29, 2015 Santiago Alvarez |
What we mean when we talk about bonds The chemical bond is still a matter of lively debate among chemists, even a century after Gilbert Lewis introduced his electron pair bonding concept. |
Chemistry World August 1, 2013 James Urquhart |
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions. |
Chemistry World June 2007 Dylan Stiles |
Opinion: Bench Monkey This PhD student takes an organic chemist's tour around the periodic table. |
Chemistry World October 23, 2009 Phillip Broadwith |
Methane all bound up US chemists have characterized the first stable sigma-methane complex in which methane binds to a metal without breaking its C-H bonds. |
Chemistry World June 2008 Philip Ball |
The Crucible By investigating how far a carbon vertex can be bent before it spontaneously flies apart, chemists can gain some understanding of the parameters within which such frameworks must operate. |
Chemistry World July 27, 2009 Simon Hadlington |
Peer review by live blogging Blogging can immediately bring together expert opinion on a given topic. Poorly reviewed papers claiming novelty can be expected to be rapidly dissected in the blogosphere, as some chemists have found out. |
Chemistry World August 11, 2010 Simon Hadlington |
Non-metal-catalysed C-C coupling Chinese chemists have successfully coupled aromatic molecules without the use of a transition metal catalyst - something that people have been trying to do for years with little success. |
Chemistry World November 7, 2007 James Mitchell Crow |
Shortest Metal Bond Chemists in the US have made a quintuply-bonded dichromium complex with the shortest metal-metal bond ever isolated. |
The Motley Fool August 10, 2005 |
What's a Bond? A bond is a loan from you to a company or government. If a company issues bonds, it's borrowing cash and promising to pay it back at a certain rate of interest. |
Chemistry World June 10, 2009 James Urquhart |
Enzyme employs unusual cleavage reaction The mechanism of an unusual carbon bond cleavage reaction in the biosynthetic pathway of phosphinothricin tripeptide (PTT) - a naturally occurring herbicide and antibiotic compound - has been elucidated by US scientists |
Chemistry World October 28, 2013 Edward Anderson |
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis. |
The Motley Fool April 24, 2007 John Rosevear |
Bonds or Bond Funds? What's the best way to add bonds to your retirement portfolio? |
Chemistry World May 22, 2015 James Urquhart |
Complex amines made easy (and cheap) Phil Baran's lab at the Scripps Research Institute, La Jolla, has come up with a protocol that repurposes two readily available and inexpensive feedstock building blocks; olefins and nitroarenes, via iron-catalysed cross-coupling. |