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Chemistry World February 9, 2012 Jennifer Newton |
A new generation of tuberculosis drugs Scientists in India are targeting enzymes responsible for catalysing the formation of bonds to repair nicks in the phosphodiester backbone of DNA - called DNA ligases - to tackle the ever-growing health concern of multi-drug resistant bacteria. |
Chemistry World August 15, 2012 |
The latent threat of tuberculosis Although TB was close to being eradicated in the developed world, it is a major problem in developing countries. With drug-resistant strains on the increase, Clare Sansom outlines the latest in the fight against this killer disease |
Chemistry World April 27, 2011 Carol Stanier |
Drug cocktails greater than the sum of their parts Canadian scientists have shown that combining an antibiotic that is past its prime with other drugs can give it a new lease of life. |
HHMI Bulletin Nov 2010 Sarah C.P. Williams |
A Study on Antibiotic Resistance Shows That Bacteria Aren't Just Out To Help Themselves Microbes that are resistant to the drug protect their weaker kin in the colony, HHMI researchers have found. The discovery upends traditional notions of antibiotic resistance and offers a target for new drugs against bacterial infections. |
Chemistry World January 3, 2013 Andrew Turley |
TB drug milestone for bedaquiline Bedaquiline (sirturo) has become the first drug to be approved in the US for the treatment of multi-drug resistant tuberculosis |
Fast Company May 2009 Elizabeth Svoboda |
Biotechs Wage War on Superbugs With antibiotic resistance on the rise, three biotechs are developing new ways to wage war on superbugs. |
Chemistry World January 8, 2015 Matthew Gunther |
New antibiotic could treat infection while dodging resistance problems A new antibiotic that can kill life-threatening bacteria -- without them appearing to be able to develop resistance to the drug -- has been discovered by a team of scientists. |
Chemistry World December 4, 2009 Lewis Brindley |
Potent two-pronged antibiotic provides hope for future drugs A two-headed compound obtained from soil bacteria may hold the key to developing the next generation of antibiotics, researchers in the UK report. |
Wired September 25, 2007 |
Three Smart Things You Should Know About Bacteria The benefits of bacteria. |
Wired May 22, 2009 Erin Biba |
New Germ Busters Outwit Antibiotic-Resistant Bacteria Researchers are testing new bug-killers that bypass the molecular pathways used by old-school antibiotics. |
Bio-IT World April 15, 2003 James Golden |
Sequence Signatures and Homeland Security The bio-IT community has a unique opportunity to contribute to national biodefense. |
Chemistry World June 18, 2015 Emma Stoye |
Crowdsourcing compounds to tackle antibiotic resistance Chemists around the world are being called on to donate samples of novel compounds they have synthesized to a crowdsourcing project that aims to find new antibiotics. |
Chemistry World July 9, 2009 Andy Extance |
Detailed crystal structure raises antibiotic hopes Scientists at King's College London and St. George's, University of London, have shown exactly how quinolones, which are the second line of defense against diseases like pneumonia and meningitis, interact with their topoisomerase IV enzyme target. |
Reactive Reports March 2005 David Bradley |
Microbial Manufacturing A bacterium is a microscopic chemical factory producing antibiotics, immunosuppressants, and anticancer drugs no chemist can synthesize. but pharmaceutical companies have been tapping into microbial drug manufacturing for some time. |
Chemistry World May 29, 2014 Carla Pegoraro |
Dual warhead kills and disarms bacteria A compound that kills bacteria and cleaves their DNA to prevent them passing on drug-resistant genes has been designed by researchers in India. |
Chemistry World August 22, 2012 Alisa Becker |
Trojan horse tuberculosis treatment The emergence of drug resistant bacterial strains has led to an urgent need for new antibiotic agents. Scientists in the US are utilizing the iron uptake pathway of Mycobacterium tuberculosis as a 'Trojan horse' approach to tuberculosis treatment. |
IEEE Spectrum February 2009 Monica Heger |
Computer-Designed Drugs Could Thwart Antibiotic-Resistant Bacteria Researchers use computer algorithms to tweak enzymes that make antibiotics |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery |
AskMen.com Harold Russell |
The Lowdown On Superbugs The overuse and misuse of antibiotics has led to the development of resistant strains of bacteria, commonly referred to as superbugs. |
Chemistry World February 22, 2011 Amaya Camara-Campos |
Repairing faulty genes Israeli scientists have developed compounds that could be better treatments for genetic diseases than current drugs. |
Chemistry World July 15, 2010 Matt Wilkinson |
Biotechs plot path of least resistance Biopharmaceutical companies are moving into antibiotics, and filling the void left by big pharma. |
Chemistry World August 26, 2007 Michael Gross |
Grapevine Genome Reveals Wine's Flavour Secrets The genome of the grapevine, Vitis vinifera, has been decoded by scientists. The research reveals the genetic origins of certain aromas and health-promoting compounds in wine. |
Chemistry World September 17, 2009 Simon Hadlington |
Targeted TB treatment Researchers in the US have discovered that a class of small molecules can selectively disable a key protein complex in the tuberculosis bacterium and kill the organism |
Reactive Reports Issue 73 David Bradley |
Gator Aid It's perhaps not the first place you would think to search for superbug-beating antibiotics, but alligator's blood could be a great source of novel compounds that could defeat strains of bacteria resistant to conventional antibiotics. |
Chemistry World February 27, 2013 Anthony King |
PharmaSea to scour ocean depths for new drugs A new project will soon see scientists trawling the ocean bottoms for new bioactive compounds. Scientists on the PharmaSea mission will haul samples of mud and sediment from the deep sea, isolating marine organisms in the hunt for novel drug candidates. |
Scientific American November 14, 2005 Gunjan Sinha |
Bugs and Drugs Gut bacteria could determine how well medicines work. |
Chemistry World May 12, 2011 Mike Brown |
Sugars recruited in fight against persistent infections Adding sugar to antibiotics can boost their effectiveness and prevent recurrent and chronic infections, according to researchers in the US. |
Chemistry World May 31, 2009 Nina Notman |
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. |
Chemistry World September 12, 2006 Mark Peplow |
Bacteria Silenced by Conversation Stoppers Molecules that interrupt the chemical conversations of bacterial communities are showing early promise in beating the bugs. |
BusinessWeek June 13, 2005 John Carey |
The NIH's Roadmap for Research Charting the human genome was just the beginning. Now the focus is creating pathways that will lead to practical applications. |
Chemistry World August 28, 2007 Tom Westgate |
Repairing DNA Could Let Frozen Bacteria Survive for Millennia An international team of scientists believe they have strong evidence that bacteria trapped in permafrost are able to survive for hundreds of thousands of years by repairing their DNA. |
Bio-IT World October 2005 Dennis A. Gilbert |
The DNA Sequencing Race: From Sprint to Marathon To create faster, cheaper, and better solutions for DNA analysis, we must remain committed to improving both current and new sequencing technologies. Research that just a short while ago might have been considered too complex, too expensive, or just inconceivable is now well within our grasp. |
Chemistry World April 3, 2008 Philip Ball |
Antibiotic-Eating Bacteria Found in Soil Scientists in the US have found that soil is full of bacteria that will feed and grow on antibiotics the very compounds created to kill them. |
Chemistry World March 13, 2013 Ned Stafford |
Antibiotic resistance is a 'ticking time bomb' Global research efforts to develop new antibiotics need to be accelerated urgently, the UK government's chief medical officer has warned. She adds that that new drugs are desperately needed to fight the 'catastrophic threat' of growing antimicrobial resistance. |
Bio-IT World September 2005 Kevin Davies |
Fantastic 454: DNA Sequencing Pyrotechnics In an exciting advance for DNA sequencing technology, a research team at 454 Life Sciences Corp. has essentially sequenced and assembled a bacterial genome sequence based on a mere 4-hour run on the company's proprietary instrument. |
Chemistry World September 11, 2013 Andria Nicodemou |
Bacteria incriminated by their odor Researchers in Taiwan and the US have developed a device that uses the volatile organic compounds released by bacteria to identify the bacteria as they are cultured. |
Bio-IT World November 14, 2003 Julia Boguslavsky |
Genome Center in a Box Scientists at 454 Life Sciences developed an integrated end-to-end instrument that performs hundreds of thousands of reactions in parallel -- from sample preparation, amplification, and sequencing to data storage and bioinformatics. |
Chemistry World November 5, 2013 Emma Stoye |
Copper signals warn bacteria of antibiotic assault Copper is known for its antimicrobial properties, but new research suggests that copper signalling within bacterial cells may also play an important role in antibiotic resistance. |
The Motley Fool January 14, 2010 Brian Orelli |
$1,000 Genomes, Here We Come Illumina jumps on news of its $10,000 genome. |
IEEE Spectrum July 2010 Prachi Patel |
Computing the Neanderthal Genome New software helped decode the DNA of our stone-age cousins |
Chemistry World April 4, 2011 Carol Stanier |
Mighty micelles that make themselves Scientists in the US and Singapore have made self assembling micelles of cationic polymers that kill bacteria but are biodegradable - raising further hope of a nanotechnology solution to the problem of antibiotic resistance. |
Chemistry World September 24, 2015 Harriet Brewerton |
Antibiotics pit against bacterial biofilms Scientists in the US have designed a simple and inexpensive electrochemical device that monitors bacteria metabolites to gauge the effect of antibiotics. |
Scientific American May 2009 Melinda Wenner |
Quiet Bacteria and Antibiotic Resistance Bacteria devoted to growth instead of "quorum sensing" communication could beat antibiotic resistance. |
Chemistry World February 22, 2010 Hayley Birch |
Soil switches on antibiotic genes in bacteria So-called 'cryptic' bacterial genes that preside over the production of medically important compounds can be switched on using environmental triggers, German scientists have shown. |
Chemistry World April 4, 2007 John Bonner |
Antibiotic Combinations Tackle Resistance Using combinations of certain antimicrobial compounds can favor the growth of non-resistant strains of bacteria at the expense of resistant ones. The surprising finding may provide a general strategy to help eradicate strains of bacteria that are resistant to antibiotic therapy. |
Chemistry World May 6, 2014 Andy Extance |
WHO raises alarm on deadly bacteria The World Health Organization has warned antibiotic resistant bacteria could bring a nightmarish future, where seemingly trivial scrapes turn lethal, and currently routine operations become too risky to contemplate. |
The Motley Fool June 23, 2010 Brian Orelli |
Duo of Diabetes Drug Deals Make J&J Better Licensing deals add to Johnson & Johnson's diabetes franchise. |
The Motley Fool November 17, 2006 Jack Uldrich |
Neanderthal DNA Enlightens Investors Investors, the superb performance of 454's gene sequencing equipment on such a difficult and important project bodes well for its future prospects. |
BusinessWeek May 9, 2005 |
A Genome Pioneer Looks Forward Dr. Francis Collins discusses the end of the Human Genome Project and says an "outpouring of discoveries" is coming soon. |
Chemistry World October 29, 2013 Harriet Brewerton |
Paper device spots antibiotic-resistant bacteria Scientists in Canada have developed a paper-based device that checks if bacteria are resistant to certain antibiotics. The simple system could help users in remote areas. |