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Chemistry World
August 29, 2012
Paul Docherty |
Amphidinolide F We're plunging into the marine depths to find natural products with prodigious biological activity. The amphidinolide family comprises over 30 members, varying in architecture but (almost) all featuring a complex and highly decorated macrolactone ring at the core.   |
Chemistry World
June 2010
Paul Docherty |
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups. |
Chemistry World
January 31, 2010
Simon Hadlington |
Ketene comes in from the cold The ketene group, -C=C=O, is capable of rich and diverse chemistry, says Craig Hawker of the University of California, Santa Barbara |
Chemistry World
June 1, 2012
Paul Docherty |
atrop-Abyssomicin C This member of the abyssomicin family is the only one to achieve bacteria-bashing prowess, and is also the only one to feature atropisomerism -- a relatively unusual form of stereoisomerism in naturally occurring species |
Chemistry World
September 2010
Paul Docherty |
Column: Totally Synthetic After a target has been synthesised, and the question of 'can we make this?' has been answered, perhaps the most important remaining question is 'how did nature make it?' |
Chemistry World
February 27, 2012
Phillip Broadwith |
Bending carbonyl reactivity rules Belgian chemists have uncovered a method to bypass the standard reactivity hierarchy of carbonyl compounds, allowing a ketone or ester to be reduced in the presence of a more reactive aldehyde. |
Chemistry World
January 6, 2010
Phillip Broadwith |
Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain. |
Chemistry World
August 2010
Paul Docherty |
Column: Totally Synthetic The total synthesis of macrolide targets is now a relatively mature field. Any synthesis that bucks these trends grabs attention, with a recent publication of dictyosphaeric acid A by Richard Taylor's team at the University of York, UK, a case in point. |
Chemistry World
July 30, 2014 |
Psylloborine A It's a somewhat surprising assertion that almost a fifth of natural products are thought to include a dimerization step somewhere in their biosynthesis. |
Chemistry World
September 9, 2009
Lewis Brindley |
Daisy-chain polymers bring artificial muscles a step closer American chemists have made molecular 'daisy-chains' containing threaded rings that can be pulled taut or slackened by chemical stimuli. |
Chemistry World
March 2010
Paul Docherty |
Column: Totally Synthetic Dimeric natural products are a common find, and represent a formidable challenge to synthetic chemists. |
Chemistry World
August 16, 2009
Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis. |
Chemistry World
February 2012
Paul Docherty |
Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities. |
Chemistry World
May 2011
Paul Docherty |
Column: Totally Synthetic The ability to understand molecular structure is perhaps both our greatest skill and largest encumbrance as scientists. A quick glance at the structure of a target such as nanolobatolide tells us much about its connectivity and the manner in which it might react. |
Chemistry World
July 2011
Paul Docherty |
Column: Totally Synthetic At first glance rippertenol looks a mere hop-skip-and-jump from its parent. However, a more careful examination reveals a stray methyl group at C1, complicating the synthesis of an already tricky target. |
Chemistry World
July 27, 2014
Simon Hadlington |
Propeller-shaped molecules give 2D polymers lift-off Crystal engineers have finally succeeded in achieving a goal that has eluded chemists for decades by unambiguously synthesizing two-dimensional polymer crystals, confirmed by single-crystal x-ray diffraction. |
