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American Journal of Nursing October 2009	Pharmacogenomics: Personalizing Drug Therapy Pharmacogenomics is a rapidly growing field of research into the ways in which genetic variation affects drug response.
Nurse Practitioner October 2011 Krauter & Cook	Pharmacogenetics and the pharmacological management of depression One CYP450 enzyme, CYP2D6, is responsible for the metabolism of 30% of all drugs including many antidepressants. Phenotypes of metabolizer status affect antidepressant treatment outcomes and adverse drug reactions.
Chemistry World July 2010 Anna Lewcock	Medicine made to measure Healthcare tailored to suit the genetic makeup of the patient is finally coming to fruition.
American Family Physician November 15, 2002 Cynthia M. Williams	Using Medications Appropriately in Older Adults Finding the right balance between too few and too many drugs will help ensure increased longevity, improved overall health, and enhanced functioning and quality of life for the aging population.
American Family Physician September 15, 2001	Guideline for the Management of Heart Failure Caused by Systolic Dysfunction: Part II. Treatment Treatment recommendations for patients with left ventricular systolic dysfunction...
Nurse Practitioner February 2011 Jennifer M. Belavic	Annual Drug Update: 2010 in Review In 2010, the FDA approved several new drugs and new indications for use in primary care. From new therapies for adults with rheumatoid arthritis to a combination drug for benign prostatic hyperplasia, NPs need to be aware of the latest medications now available.
Bio-IT World September 9, 2002 Malorye Branca	The New, New Pharmacogenomics The field of pharmacogenomics proves valuable in the battle against toxicity and late-stage drug failure -- one of the pharmaceutical industry's biggest problems.
American Family Physician August 1, 2002 Daphne P. Bicket	Using ACE Inhibitors Appropriately Although angiotensin-converting enzyme (ACE) inhibitors have documented clinical benefits in a variety of clinical situations, the disparity between the evidence from clinical trials and bedside medicine is well documented.
American Family Physician July 15, 2000 Showkat A. Haji	Update on Digoxin Therapy in Congestive Heart Failure Congestive heart failure is a progressive disease with significant morbidity and mortality. Despite advances in the prevention and treatment of cardiovascular diseases, the incidence and prevalence of congestive heart failure have increased in recent years...
Nursing June 2010 Daniel A. Hussar	New drugs 2010, part 2 In this article, you'll learn about 14 recently marketed new drugs.
American Family Physician February 1, 2005 Dickerson & Gibson	Management of Hypertension in Older Persons Antihypertensive therapy has been shown to reduce morbidity and mortality in older patients with elevated systolic or diastolic blood pressures.
Pharmaceutical Executive July 1, 2011 Dickmeyer & Rosenbeck	From Rut to Racetrack Can the pharmaceutical industry deliver on its objective to make cancer a curable, chronic condition?
American Family Physician October 15, 2001 Katherine L. Margo	Spironolactone in Left-Sided Heart Failure: How Does It Fit In? The familiar diuretic spironolactone has taken on new life as a treatment for left-sided congestive heart failure. More research is necessary to determine the order and combinations of spironolactone and other medications in slowing the progression of this disease...
Nursing February 2010 Daniel A. Hussar	New Drugs 2010, PART 1 In this article, you'll learn about 16 new drugs.
Nursing June 2011 Daniel A. Hussar	New Drugs 2011: Part 2 In this article, you'll learn about seven recently approved drugs, including: fingolimod hydrochloride, an oral drug indicated to treat patients with relapsing forms of multiple sclerosis.
American Family Physician December 1, 2004 McConaghy & Smith	Outpatient Treatment of Systolic Heart Failure Optimal outpatient treatment of systolic heart failure has three goals that should be pursued simultaneously: (1) control of risk factors for the development and progression of heart failure, (2) treatment of heart failure, and (3) education of patients.
Nurse Practitioner July 2010 Kristine A. Scordo	Treating antiretroviral-induced dyslipidemia in HIV-infected adults Studies indicate that HIV-infected patients (both males and females) may be at an increased risk for the development of cardiovascular disease
American Family Physician December 1, 2003 Lyle A. Siddoway	Amiodarone: Guidelines for Use and Monitoring Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. The drug prevents the recurrence of life-threatening ventricular arrhythmias and produces a modest reduction of sudden deaths in high-risk patients.
BusinessWeek September 5, 2005 Capell & Arndt	Drugs Get Smart Future medicines will more effectively target what ails you by tailoring treatment to your specific genetic profile. Personalized medicine will also help prevent another Vioxx.
Bio-IT World October 9, 2002 Kevin Davies	Affairs of the Heart A newly discovered SNP in the cardiac sodium channel is unusually common in people of African descent, and may predispose them to potentially life-threatening arrhythmias in conjunction with other risk factors.
Nurse Practitioner March 2009 Patricia Weyland	Warfarin Therapy Management :Tap in to New Ways to Slow the Clot Patients on warfarin require close monitoring in order to decrease their risk of clotting, while also decreasing their risk of bleeding.
American Family Physician April 15, 2001 Robert E. Hoyt & Lester Shawn	Reducing Readmissions for Congestive Heart Failure Hospital admission for congestive heart failure is extremely common and quite expensive, although it is frequently preventable...
Nursing March 2012 Daniel A. Hussar	New Drugs 2012: part I In this article, you'll learn about 11 recently approved drugs.
Pharmaceutical Executive November 1, 2011 Elizabeth O. Coulton	Clinical Trial Issues Not Just Black and White The selection of clinical trial participants must meld with the changing demographics of America if industry is to improve medicines that work for patients.
American Family Physician August 1, 2002 Mark W. Niedfeldt	Managing Hypertension in Athletes and Physically Active Patients Athletes and other physically active patients should be screened for hypertension and given appropriate therapy if needed.
Nursing July 2008 Daniel A. Hussar	New Drugs08, Part 2 Here, you'll learn about eight new drugs, including doripenem, maraviroc and ixabepilone.
Managed Care August 2004 Thomas Morrow	10,000 Cells on a Chip Signal Start of New Era of Diagnosis Diseases will soon be defined by biochemical pathways and genetic interactions. Biochips may identify patients likely to respond to therapeutic agents. All of this is a big deal for health plans.
American Family Physician September 1, 2003 Magill et al.	New Developments in the Management of Hypertension Advances in the management of hypertension have refined our understanding of systolic blood pressure, nutrition, medication selection, and hypertension in special populations.
Managed Care November 2006 Maureen Glabman	Genetic Testing: Major Opportunity, Major Problems Whether a person is likely to develop diabetes, cancer, schizophrenia, or stroke will be reasonably well predicted, and tests can also determine whether a patient will respond to a given therapy. That's the good part.
American Family Physician October 1, 2002 Konzem et al.	Controlling Hypertension in Patients with Diabetes Hypertension and diabetes mellitus are common diseases in the United States. Patients with diabetes have a much higher rate of hypertension than would be expected in the general population. Regardless of the antihypertensive agent used, a reduction in blood pressure helps to prevent diabetic complications.
BusinessWeek January 21, 2010 John Carey	Making Personalized Medicine Pay Medco and other pharmacy benefit managers say future profits depend on matching drugs to patients based on their genes.
American Family Physician July 1, 2005 Micah L. Thorp	Diabetic Nephropathy: Common Questions Diabetic nephropathy, or diabetic kidney disease, affects 20% - 30% of patients with diabetes. This article addresses some of the common questions raised by physicians managing patients with this disease.
Bio-IT World November 14, 2003 Kathy Ordonez	Targeted Medicine via Molecular Diagnostics Using diagnostics to select and deselect target populations for drug therapy will enable life scientists to make more effective medicines.
Nurse Practitioner February 2012 Jennifer M. Belavic	Annual drug update 2011 in review Many new medications were approved throughout 2011. This article will cover a variety of drugs that will be useful in nurse practitioner practice
Nursing February 2009 Daniel A. Hussar	New Drugs 09: Part 1 Learn about 10 new drugs, including nebivolol HCl, the newest beta-adrenergic blocking agent for hypertension.
Bio-IT World October 9, 2002 Malorye Branca	The Path to Personalized Medicine The tactics have changed, sometimes dramatically, but hints of the promise of pharmacogenomics are finally starting to trickle in from studies of asthma, cancer, and drug response.
BusinessWeek June 27, 2005 Amy Barrett	Color-Blind Drug Research Is Myopic Researchers will sometimes have to use the blunt instrument of race to help match patients with the right drugs.
Bio-IT World September 9, 2002 Kevin Davies	The Debate Over Race Relations Are self-identified labels of race useful in large-scale population genetic studies? A provocative commentary from a leading Stanford University geneticist has fuelled controversy.
American Family Physician June 1, 2005 O'Brien & Chennubhotla	Treatment of Edema Major causes of edema include venous obstruction, increased capillary permeability, and increased plasma volume secondary to sodium and water retention. A systematic approach is warranted to determine the underlying diagnosis.
Chemistry World July 2010 Hayley Birch	Special Report: Health breakthroughs of the decade New discoveries have been made with cancer vaccines, genomics, statin drugs, allosteric modulators, and RNA interference during the last decade.
American Family Physician June 15, 2005 Hanna & Wenger	Secondary Prevention of Coronary Heart Disease in Elderly Patients A review of the scientific evidence for the secondary prevention of coronary heart disease in the elderly.
Nursing August 2008 Carl A. Kirton	Managing Long-Term Complications of HIV Infection Now that advances in treatment have transformed HIV into a chronic, manageable disease, patients are facing cardiovascular and metabolic complications you might not have expected 15 years ago. Here's how to help your patient manage them.
American Family Physician October 15, 2000 Patricia A. Howard & Edward F. Ellerbeck	Optimizing Beta-Blocker Use After Myocardial Infarction Although beta-adrenergic blockers can significantly reduce mortality after a myocardial infarction, these agents are prescribed to only a minority of patients...
American Family Physician August 15, 2006 Morris, Hatcher & Reddy	Digoxin Therapy for Heart Failure: An Update Digoxin therapy has long been used to treat heart failure; however, its effectiveness was not completely known until recently. Results of the Digitalis Investigation Group trial showed that adding digoxin to standard heart failure therapy had no effect on mortality.
American Family Physician October 1, 2003 Vincent W. Delagarza	Pharmacologic Treatment of Alzheimer's Disease: An Update Alzheimer's disease is characterized by the development of senile plaques and neurofibrillary tangles, which are associated with neuronal destruction, particularly in cholinergic neurons. Drugs that inhibit the degradation of acetylcholine within synapses are the mainstay of therapy.
BusinessWeek September 5, 2005	Putting the FDA Out Front Deputy Commissioner Dr. Janet Woodcock explains how the agency has led the drive for personalized medicine.
Bio-IT World November 2005 Khaleeli & Fernandez	Patent Prosecution and Enforcement in Pharmacogenomics Patenting the composition of an isolated nucleic acid sequence, an isolated protein, and small molecules is possible, but there are challenges claiming that they resulted from pharmacogenomic research.
American Family Physician November 1, 2003 Scow et al.	Combination Therapy with ACE Inhibitors and Angiotensin-Receptor Blockers in Heart Failure This article reviews the literature and available evidence on the use of ACE inhibitors and angiotensin-receptor blockers in combination for the treatment of patients with congestive heart failure.
Bio-IT World May 2006 Kevin Davies	Decoding the Genetics of Common Disease Icelandic biopharma deCODE Genetics' Kari Stefansson says his company's search for genes underlying common diseases is not only pushing promising new drug candidates into the clinic but also revealing new insights into the very basis of common disease.
Nursing February 2012 Pezzotti & Freuler	Using anticoagulants to steer clear of clots This article will review coagulation and provide important information about several commonly used anticoagulants and their reversal agents.