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Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today. |
Chemistry World December 4, 2009 James Urquhart |
Easier ester synthesis Researchers in the US have shown how oxygen-coated gold nanoparticles can selectively oxidise a variety of alcohols and aldehydes. |
Chemistry World October 15, 2012 John Hayward |
Oxidizing agents Oxidation in Organic Synthesis by V.K .Ahluwalia contains an extensive list of reagents and is of some interest as a reference resource, particularly with respect to some of the more exotic reagents. |
Chemistry World January 25, 2013 Derek Lowe |
Name reactions: how does the label stick? Some of these names go back to the 19th century, and many more of them come from the first decades of the 20th. Once in a while, I wonder if the tradition is dying out. Are we still naming chemical reactions after their discoverers? |
Chemistry World February 27, 2012 Phillip Broadwith |
Bending carbonyl reactivity rules Belgian chemists have uncovered a method to bypass the standard reactivity hierarchy of carbonyl compounds, allowing a ketone or ester to be reduced in the presence of a more reactive aldehyde. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World July 27, 2009 Simon Hadlington |
Peer review by live blogging Blogging can immediately bring together expert opinion on a given topic. Poorly reviewed papers claiming novelty can be expected to be rapidly dissected in the blogosphere, as some chemists have found out. |
Chemistry World October 23, 2013 Emma Eley |
Synthesis by sunlight Sustainable oxidation reactions can be performed with inexpensive and readily available photovoltaic cells |
Chemistry World October 2007 Derek Lowe |
In the Pipeline One of the biggest areas of chemical research these days is in catalytic processes. It's one of the places we can really improve our processes, especially when you count the waste stream (as you should) as part of the total energy bill. |
Chemistry World February 22, 2008 James Mitchell Crow |
Rhodium Fast Tracks Route to Lactones Chemists in Canada have developed an efficient new way to make lactones, chemical components of many natural products and drugs. |
Chemistry World September 2, 2010 James Urquhart |
Challenging aqua regia's throne An 'organic' aqua regia which can selectively dissolve noble metals in solution has been discovered by researchers in the US. |
Chemistry World April 2010 Paul Docherty |
Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance. |
Chemistry World January 2010 Paul Docherty |
Column: Totally Synthetic Of all the natural product classes, the steroid family are perhaps the most prevalent in the public consciousness; from cholesterol to testosterone, their infamy inflates the 'science bit' in countless advertisements. |
Chemistry World July 2009 Paul Docherty |
Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target. |
Chemistry World September 4, 2008 Fred Campbell |
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot. |
Chemistry World February 4, 2011 Elinor Richards |
Strychnine in just six steps Strychnine, best known as a poison but also used medicinally as a stimulant, can now be synthesised in just six steps, say US scientists. |
Chemistry World April 2011 Paul Docherty |
Column: Totally Synthetic Reactions in the synthesis of guanacastepene N. Discovered in fungi growing on trees in the Guanacaste conservation area in Costa Rica, several syntheses of this family have appeared in the decade since their isolation. |
Chemistry World May 2012 Paul Docherty |
Column: Totally Synthetic Hopeanol and hopeahainol A |
Chemistry World March 2010 Paul Docherty |
Column: Totally Synthetic Dimeric natural products are a common find, and represent a formidable challenge to synthetic chemists. |
Chemistry World February 2011 Paul Docherty |
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw. |
Chemistry World April 2009 Paul Docherty |
Column: Totally Synthetic Perhaps the most frustrating part of being a synthetic chemist is the jealousy with which we must regard nature |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. |
Chemistry World December 2, 2008 James Mitchell Crow |
Just add air for cleaner carbon bonding UK scientists have found a new way to clip together organic molecules that could be the ultimate green approach to making carbon-carbon bonds |
Chemistry World December 2010 Paul Docherty |
Column: Totally Synthetic In a conversation at the beginning of this year, a friend and I considered the most challenging targets available to the total-synthesizer - and maoecrystal V was at the top of the list. |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. |
Chemistry World February 2012 Paul Docherty |
Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities. |
Chemistry World June 2010 Paul Docherty |
Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups. |