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Chemistry World January 2, 2013 Derek Lowe |
Fear of the unknown My mental file drawer labelled 'Terrible Reagents I Have Known' is even larger than the one called 'Lunatics I Have Worked With and their Life-Threatening Ideas'. We organic chemists really do work with some terrible chemicals, and it's up to us to keep them from causing havoc. |
Chemistry World March 27, 2014 Derek Lowe |
Known unknowns Most dangerous substances announce themselves by their structures and reactivity, and a competent organic chemist should be able to read those signs. |
Chemistry World June 1, 2012 Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Chemistry World October 2011 Derek Lowe |
Column: In the Pipeline Research chemistry has hazards, some of them potentially fatal, and attention to safety is an essential part of working in the field. The hard part comes when you try to figure out what sort of 'attention to safety' is most helpful. |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World February 2008 Dylan Stiles |
Column: Bench Monkey Cast a skeptical eye over new ideas in chemistry. |
Chemistry World September 2008 Derek Lowe |
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful' |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. |
Chemistry World June 2008 |
Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team. |
Chemistry World October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery |
Chemistry World June 2011 |
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most. |
Chemistry World July 2008 Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril |
Chemistry World August 2009 Derek Lowe |
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder |
Chemistry World April 2009 Derek Lowe |
Column: In the pipeline The author considers the problems of addressing drug development out of sequence |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World February 2008 Derek Lowe |
Column: In the Pipeline Does it matter whether or not a pharmaceutical company is run by a chemist? |
Chemistry World August 28, 2015 Derek Lowe |
A risky business How much of a risk is it to work in an organic chemistry lab? Back when I was first beginning bench work in graduate school, I was home during the holidays and telling some lab stories. |
Reactive Reports December 2006 David Bradley |
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database. |
Chemistry World January 25, 2013 Derek Lowe |
Name reactions: how does the label stick? Some of these names go back to the 19th century, and many more of them come from the first decades of the 20th. Once in a while, I wonder if the tradition is dying out. Are we still naming chemical reactions after their discoverers? |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World March 3, 2015 Peter Reed |
Important figures of analytical chemistry from Germany in brief biographies: from the middle ages to the twentieth century This book makes a useful addition to the chemical literature and is recommended to chemists and, in particular, historians of chemistry. |
Chemistry World July 30, 2015 Derek Lowe |
A precision instrument? How much do medicinal chemists and their biology colleagues really trust each other's data? In the end, they have to, because drug discovery is a team sport. |
Chemistry World March 22, 2012 David Bradley |
Taming an explosive chemical tiger Diazomethane - CH 2N 2 - is an extremely useful reagent: it can be used in aziridination, carbonyl homologation, cyclopropanation, dipolar cycloaddition, epoxidation, esterification reactions and more. |
HHMI Bulletin Nov 2011 Sarah C.P. Williams. |
Carolyn Bertozzi: Changed Expectations Chemists trained in biology were once a rarity -- now they're becoming the norm. |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. |
Chemistry World March 6, 2013 Jon Evans |
Data challenges for UK chemists Academic chemists in the UK have a problem with data. That's the claim made by a report that says that both in terms of managing and sharing data produced by their own laboratories and accessing data produced by others, chemists are all at sea. |
Chemistry World September 2006 Yfke Hager |
Careers: Analytical Expertise After years of jumping between chemistry jobs, Adam Hold created his dream career by setting up his own company to provide analytical services. |
Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today. |
Chemistry World November 2009 |
Column: Undercover academic Good laboratory techniques are key skills for a chemistry graduate. All chemists need an appropriate level and range of practical skills. |
Chemistry World September 4, 2012 Derek Lowe |
Light in the Lab We organic chemists do terrible things to our molecules. How about dissolving the starting materials up in a flask, shining a light into the mixture and coming back later to find it transformed into your product? That's photochemistry. |
Reactive Reports Issue 66 David Bradley |
Nuclear Chemist's Love of the Web Benefits Chemists Everywhere Mitch Andre Garcia uses the internet to help the chemistry community. His latest web creation is a ranking tool which allows users to submit research papers of interest and for others to vote on their worthiness or otherwise. |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions |
Chemistry World September 26, 2012 Derek Lowe |
Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run? |
Reactive Reports Issue 71 David Bradley |
Reactive Profile--Sun Rises in the East Interview with graduate student Weixiang Sun on constructing nanoscale materials from the bottom up. |
Chemistry World February 2012 |
Column: In the pipeline Every lab should have a common working language (presumably that of the country where it's located), and it should be the responsibility of every person in it to be able to at least get along with its basic vocabulary. |
Chemistry World December 2007 Richard Van Noorden |
Surfing Web2O The rapid evolution of the world wide web is creating fresh opportunities - and challenges - for chemistry. |
Chemistry World June 5, 2015 |
A prescription for chemists The Public attitudes to chemistry survey revealed that many people confuse chemists with pharmacists. |
HHMI Bulletin Nov 2011 Sarah C. P. Williams |
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. |
Chemistry World September 25, 2015 Derek Lowe |
Spice up your compounds You and your team are optimizing a lead compound, as medicinal chemists are wont to do -- varying its structure to improve its potency, selectivity and other properties. |
Reactive Reports Issue 45 |
Star Picks Chemistry Web sites: Chemists Celebrate Earth Day: Resources... Doing Chemistry... Chemistry Question... |
Chemistry World August 29, 2006 |
Conference Blog About 3000 chemists have gathered in Budapest, Hungary, for the first European Chemistry Congress: Radish Sango on the Menu... Robots in the Lab... Speed Chemistry... etc. |
Chemistry World August 13, 2015 |
Exploiting the data mine Chemists must embrace open data to allow us to collectively get the best out of the masses of new knowledge we unearth, reports Clare Sansom |
Chemistry World October 2, 2013 Rebecca Trager |
US employment picture brightens for chemists The employment picture for US chemists and chemical engineers brightened from 2012 to 2013, with the jobless rate dropping from 4.2% to 3.5% and median salaries for all chemists increasing by 2.2%. |
Chemistry World March 30, 2015 Katrina Kramer |
Chemistry: a very short introduction I heartily recommend this book -- it is an enjoyable read both for chemists and non-chemists alike. Part of the Very short introduction series, it fits perfectly into every suit or lab coat pocket. |
Chemistry World March 20, 2007 Tom Westgate |
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries. |
Chemistry World July 23, 2012 Andrea Sella |
Chattaway's spatula Frederick Chattaway British chemist (1860-1944), was a careful and painstaking explorer of the chemical world. He studied some of the most dangerous compounds known, and was prepared to drop academic security for something more interesting. |
Chemistry World December 1, 2014 Derek Lowe |
Progress at the pace of the slowest Chemistry is a means to an end in drug research, not an end in itself, and that can take some getting used to. It's worth thinking about where chemistry fits into the big picture. |
Chemistry World November 28, 2013 |
What is chemistry? This book is designed to tell the average person all about chemistry, and in a way they can understand. |
Reactive Reports Issue 51 David Bradley |
Jean-Claude Bradley Drexel University and Blogmaster of Usefulchem.Blogspot.Com This chemist is the creator of a fascinating blog (Web log) called UsefulChem, which aims to bring important and global problems to the attention of the wider chemical community in the hope of finding chemistry-based solutions. |