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Chemistry World April 19, 2009 Hayley Birch |
Chiral metals shape up for catalysis Dutch and Israeli scientists have found a way to induce the chirality usually only found in organic materials in palladium. |
Chemistry World June 5, 2012 Simon Perks |
Chiral separation with micro-flows How do you separate enantiomers without any kind of chiral recognition between molecules? The answer it seems is to use asymmetric flow in a micro-fluidic channel. |
Chemistry World July 26, 2007 Tom Westgate |
Counterion Does the Twist US chemists have achieved a breakthrough in the design of catalysts that selectively produce chiral compounds. |
Chemistry World October 18, 2011 Steve Down |
Cofactor Control of Catalysis Enantioselectivity Scientists have used cofactors to control the enantioselectivity of supramolecular transition metal catalysts, enabling the asymmetric hydrogenation of a series of acrylates and related compounds with remarkably high selectivities. |
Chemistry World March 8, 2011 Jon Cartwright |
Carbon nanotubes - a boon for chiral catalysts Researchers in China have created a new catalyst that could help in the production of chiral molecules for medical drugs. The catalyst, which consists of platinum nanoparticles encapsulated in carbon nanotubes, is the most active of its type ever reported. |
Chemistry World March 23, 2009 Hayley Birch |
Speeding up screening for chiral catalysts U.S. researchers say their method represents a 'standard workhorse' for discovery and optimisation of chiral catalysts, such as those widely used by the pharmaceutical and pesticide industries. |
Chemistry World November 28, 2013 Andy Extance |
Base metal catalysts strike hydrogenation gold Three teams have shown that chemists need not rely only on expensive and toxic precious metal catalysts for hydrogenation -- they've found complementary alternatives based on cheap, abundant and safer transition metals. |
Chemistry World October 16, 2015 Philippa Matthews |
One pot recipe for incompatible catalytic transformations Researchers from the US have demonstrated a new catalyst support structure allowing two incompatible catalysts to work in tandem. |
Chemistry World November 3, 2014 Debbie Houghton |
Engineered metalloenzyme catalyses Friedel -- Crafts reaction Reprogramming the genetic code of bacteria to incorporate an unnatural amino acid has allowed scientists in the Netherlands to create a new metalloenzyme capable of catalyzing an enantioselective reaction. |
Chemistry World November 17, 2008 Simon Hadlington |
Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions |
Chemistry World May 30, 2013 Andy Extance |
Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity. |
Chemistry World October 14, 2009 James Urquhart |
New route to amino acids US scientists have found a new way of making a class of non-natural amino acids that are widely used as components of pharmaceuticals and chiral catalysts. |
Chemistry World May 15, 2012 Harriet Brewerton |
Chiral Confusion Scientists in Israel have shown that non-biological chiral crystals are much more abundant than previously thought and their findings could clear up a possible confusion over the term 'chiral'. |
Chemistry World September 6, 2006 Michael Gross |
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses. |
Chemistry World December 23, 2015 Karl Collins |
Scratching chiral surfaces There are numerous challenges to developing reactions that exploit chiral surfaces, or employ molecular modifiers (ligands) to create a chiral surface environment and control the stereoselectivity of a transformation. |
Chemistry World June 10, 2010 Phillip Broadwith |
A green and salty chiral catalyst An efficient, chiral, salt-based hypervalent iodine catalyst has been discovered by Japanese chemists that could replace toxic metal catalysts without generating the waste or explosion risks associated with hypervalent organo-iodine complexes. |
Chemistry World November 26, 2010 Amaya Camara-Campos |
Enriching the origin of life theory An enantioenrichment of the amino acid valine, which could shed light on the origin of chirality on Earth, has been achieved by scientists in Spain. |
Chemistry World June 1, 2006 Michael Gross |
New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions. |
Chemistry World March 5, 2014 Andy Extance |
Rotaxanes make symmetry history A UK team has stumbled upon an efficient way to separately produce each member of an unusual mirror image pair of chemical systems that has eluded scientists for over four decades. |
Chemistry World November 6, 2009 Phillip Broadwith |
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. |
Chemistry World May 9, 2010 Phillip Broadwith |
Iron catalyst breaks the mold An iron catalyst that is not only greener than many of its precious metal competitors, but also catalyses reactions that they can't, could open new avenues in transition metal catalysis, say Chinese researchers. |
Chemistry World August 7, 2011 Phillip Broadwith |
Possible Origin of Chirality in the Rna World Given a tiny push one way or the other, simple racemic precursors can lead to the chiral building blocks of RNA using a combination of chemical and physical factors. |
Chemistry World March 2, 2007 Philip Ball |
Giving Life a Hand Why are proteins left-handed and nucleic acids right-handed? Once offered only a few sketchy theories, scientists have found more alternatives for creating homochirality. |
Chemistry World February 6, 2015 Elisabeth Ratcliffe |
Exploiting the chirality of DNA DNA has emerged as an innovative way of controlling the chirality of a reaction product by binding catalysts in such a way that one enantiomer is preferentially generated. |
Chemistry World June 18, 2014 Michael Parkin |
Separation by levitation A team in the US has shown that enantiopure and racemic crystals can be separated by magnetic levitation. |
Chemistry World February 21, 2008 Lewis Brindley |
Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals. |
Chemistry World July 3, 2015 Andy Extance |
Copper catalysis overcomes double bond trouble Some carbon-carbon double bonds seem too unreactive for synthetic use -- but that's just how chemists in the US are now exploiting them. |
Chemistry World October 31, 2014 Andy Extance |
Acid choice flips enantioselectivity Organic chemists in Ireland have developed a pair of reactions they think are unique in producing predominantly one of two mirror-image products without a change of catalyst. |
Chemistry World June 13, 2008 Richard Van Noorden |
Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers. |
Chemistry World April 8, 2008 Mark Peplow |
Meteorite Source for Life's Handedness Scientists have long speculated that life's preference for left-handed amino acids may have been triggered by compounds brought to Earth by meteorites. Now they've shown exactly how two crucial steps in this process could happen. |
Chemistry World June 17, 2013 Eleanor Merritt |
Switching chirality in amino acids An international team of scientists has developed a purely chemical approach to interconvert L- and D-amino acids. This method could rival enzymatic routes used in industry, and enable cheaper production of some pharmaceuticals. |
Chemistry World November 7, 2014 Katrina Kramer |
Stressed ligands switch catalysis selectivity Researchers have discovered that enantioselectivity in palladium-catalyzed reactions depends on the ligand's intramolecular strain. |
Chemistry World February 10, 2011 James Urquhart |
Molecular motor controls chirality A single molecule catalytic system that uses a light driven molecular motor to dynamically control the molecule's chiral states has been developed by scientists in the Netherlands. |
Chemistry World May 3, 2013 Alison Rodger |
VCD spectroscopy for organic chemists I highly recommend VCD Spectroscopy, by Philip Stephens and others, for organic chemists as the textbook of choice on this useful topic. |
Chemistry World February 19, 2010 Simon Hadlington |
Forcing stereoselectivity on reactive cations Chemists in the US have devised a dual catalyst strategy to tame the highly reactive iminium ion to give a high degree of stereochemical control over subsequent reactions of the ion. |
Chemistry World May 26, 2015 Victoria Richards |
Crystalline sponge method strikes again Scientists from Japan report that their revolutionary crystallographic technique has determined the stereochemistries of molecules with axial and planar chiralities, where classical methods had failed. |
Chemistry World February 21, 2007 Tom Westgate |
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules. |
Chemistry World December 17, 2009 Simon Hadlington |
Single catalyst gives two products from racemic mixture Chemists in the US have demonstrated a remarkable reaction in which a single catalyst can transform a racemic mixture - molecules identical in every way except for their chirality - into two distinct enantiomerically pure products. |
Chemistry World November 3, 2011 Erica Wise |
A Model for the Single Chirality of Life The boiling solutions in prebiotic hot springs could shed light on the emergence of a single chiral form of biomolecules in nature, say Spanish scientists. |
Chemistry World March 20, 2007 Tom Westgate |
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries. |
Chemistry World September 2, 2009 Phillip Broadwith |
Shining a light on DNA-binding drugs in living cells German researchers have used standard circular dichroism spectroscopy to probe interactions between drug molecules and DNA within living cells. |
Chemistry World February 1, 2006 Michael Gross |
Chiral Catalysis on a Chip Chiral catalysis and analytical separation of the resulting enantiomers can now be performed on a single chip. The process could be scaled up to serve in high throughput screening for new enantioselective catalysts, claim the chemists who developed the chip. |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists. |
Chemistry World June 17, 2010 Andrew Turley |
Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy. |
Chemistry World May 15, 2014 Jenifer Mizen |
Freeze-dried cells make better biocatalysts A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses. |
Chemistry World May 24, 2013 David Bradley |
Microwaves show their hand The chirality of a gas phase molecule held in an electric field can be revealed using microwave spectroscopy. Hooking the technique to a separation step might even be exploited to isolate a specific enantiomer from a racemic mixture of both forms. |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction. |
Chemistry World July 24, 2009 Nina Notman |
Chiral isotropic liquids from achiral molecules Boomerang-shaped liquid crystal phase molecules that don't exhibit 'handedness' (chirality) have been found to form unusual chiral structures that spontaneously separate into left- and right-handed domains. |
Chemistry World April 25, 2010 Hayley Birch |
New strategy yields best ever catalyst for ammonia decomposition US researchers have developed a new strategy for predicting bimetallic catalysts. |
Chemistry World July 5, 2013 Andre Cobb |
Principles of asymmetric synthesis (2nd edition) The first edition of this book in 1996, by Bob Gawley and Jeff Aube was one of the essential texts for chemists aspiring to understand the fundamentals of constructing stereochemically pure molecules. |