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Chemistry World
July 2009
Derek Lowe |
Column: In the pipeline The author wonders where we'd be without the formulation chemists   |
Chemistry World
June 2011 |
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most. |
Chemistry World
January 2012 |
Column: In the pipeline Derek Lowe discusses how companies are increasingly trying to do more with the compounds they already know a lot about |
Chemistry World
April 2009
Derek Lowe |
Column: In the pipeline The author considers the problems of addressing drug development out of sequence |
Chemistry World
November 2008
Derek Lowe |
Column: In the pipeline Drug discovery chemists live by assay data; we depend on these numbers to tell us if we're heading in the right direction with our molecules. |
Chemistry World
September 2007
Derek Lowe |
Column: In the Pipeline Will Phase Zero trials actually help drug development? |
Chemistry World
October 2010 |
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery |
Chemistry World
June 2008
Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World
November 2009
Derek Lowe |
Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times |
Chemistry World
August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World
January 2009
Derek Lowe |
Column: In the pipeline The author discusses the age-old tradition of passing the buck in drug development. |
Chemistry World
October 2008
Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat' |
Chemistry World
January 2, 2013
Derek Lowe |
Fear of the unknown My mental file drawer labelled 'Terrible Reagents I Have Known' is even larger than the one called 'Lunatics I Have Worked With and their Life-Threatening Ideas'. We organic chemists really do work with some terrible chemicals, and it's up to us to keep them from causing havoc. |
Chemistry World
February 3, 2011
Ben Merison |
The mystery of the disappearing crystals UK chemists have analysed a fifty year old sample to find out why and say that it's down to impurities. This takes researchers a step closer to understanding why certain pharmaceutical drugs lose their therapeutic effect. |
Chemistry World
June 1, 2012
Derek Lowe |
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. |
Chemistry World
March 2012 |
Column: In the pipeline Drug discovery requires experimentation, says Derek Lowe. But chemists can be reluctant to stray from the elements they know and love |
Chemistry World
June 2010 |
Column: In the pipeline Derek Lowe looks into his crystal ball to see what the future of medicinal chemistry might be |
Chemistry World
August 2007
Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Chemistry World
April 2011 |
Column: In the Pipeline If you look over the whole pharmacopeia, you'll see there are a lot of compounds that got their start as natural products. |
Pharmaceutical Executive
February 1, 2006
Ron Feemster |
Gene Logic: Rescue Squad One or two late-stage clinical failures can land promising drug candidates on the shelf. Forever? Maybe not. Gene Logic tests Big Pharma's dead drugs for hundreds of different targets. |
Chemistry World
July 2008
Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril |
