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Chemistry World
November 3, 2011
David Bradley |
Faster Synthesis of Fluorine Radioisotope Imaging Agents A palladium-containing fluorination reagent can be used to quickly synthesise aromatic molecules labelled with fluorine-18, a positron emitter used in molecular imaging.   |
Chemistry World
August 17, 2009
James Urquhart |
New method for fluorinating compounds Fluorine atoms are incorporated into aromatic organic compounds for many reasons, including their ability to increase metabolic stability, solubility and bioavailability. |
Chemistry World
January 11, 2013
Marie Cote |
Following her passion Veronique Gouverneur is professor of chemistry at the University of Oxford, UK. She investigates fluorine chemistry and is working on developing novel synthetic methodologies for the preparation of fluorinated targets. |
Chemistry World
August 15, 2011
Simon Hadlington |
Trifluoromethylation Made Easy US researchers have discovered a simple, low-cost way to add fluorine atoms to heteroaromatic rings. |
Chemistry World
March 19, 2009
Manisha Lalloo |
Copper catalysts give meta aromatics UK Researchers have discovered that, simply by using a copper catalyst, they are able to perform tricky substitution reactions at a difficult position on benzene rings |
Chemistry World
July 2008
Kevin Rogers |
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril |
Chemistry World
December 19, 2012
Amy Middleton-Gear |
Early Alzheimer's diagnosis compound UK and US scientists have developed a labelled tracer compound that binds to plaques closely associated with Alzheimer's disease so that the plaques can be picked up by a medical imaging technique. |
Chemistry World
May 29, 2015
Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World
August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World
June 2008
Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World
January 2011 |
Column: In the pipeline Some medicinal chemists can't get enough fluorines in their molecules. The love-hate relationship is explained. |
Chemistry World
June 14, 2006
Simon Hadlington |
Natural Metabolism of Fluorine Scientists have isolated a cluster of bacterial genes responsible for the biochemical processing of fluorine. The research follows the discovery of a unique enzyme that incorporates inorganic fluoride into organic metabolites. |
Chemistry World
August 2007
Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Chemistry World
August 2009
Derek Lowe |
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder |
Chemistry World
September 28, 2015
Karl Collins |
A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research. |
Chemistry World
September 13, 2012
Ian Le guillou |
Fluorination via porphyrin A manganese porphyrin has been used to selectively fluorinate sp 3 carbon -- hydrogen bonds using silver fluoride as a source of fluorine. |
Chemistry World
December 21, 2006
Tom Westgate |
Molecular Probe Identifies Patients at Risk of Alzheimer's A new molecule could provide an early warning system for Alzheimer's disease, US researchers hope. |
Chemistry World
June 12, 2007
Simon Hadlington |
A New Way to Look at the Brain Researchers have for the first time scanned the human brain with positron emission tomography and magnetic resonance imaging simultaneously. The work introduces the possibility of obtaining both highly specific functional data together with anatomical information in a single scan. |
Chemistry World
September 20, 2012
Jessica Cocker |
Biological fate of nanoparticles in the body Nanoparticles are extremely difficult to detect and measure once they are distributed in a biological system. Now, Spanish scientists have developed a novel way for measuring their biodistribution. |
