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Chemistry World January 20, 2011 Hayley Birch |
Programmable RNA promising for bio-compatible therapies Programmable nanostructures based on ribonucleic acid could be used as vessels for shipping therapeutic molecules into cells, according to US scientists. |
Bio-IT World December 15, 2004 David A. Bumcrot |
Identifying RNAi Drug Candidates Breakthroughs in understanding RNA's extensive role in essential cellular processes have opened up the potential for a whole new class of drugs based on RNAi. |
Chemistry World April 28, 2008 Victoria Gill |
Gene silencing gets fat A team of researchers in the US has developed fat-like nanoparticles that can carry fragments of RNA into cells, bring treatments based on gene silencing a step closer. |
Chemistry World June 9, 2008 Simon Hadlington |
Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes. |
Chemistry World January 31, 2008 John Bonner |
RNAi Scores Victory Against Crohn's Disease in Mice Thousands of people suffering from the debilitating gut condition Crohn's disease could experience relief from their symptoms through a technique that blocks production of a key protein in the inflammation process. |
Chemistry World March 21, 2010 Simon Hadlington |
Nanoparticles successfully deliver RNA interference in cancer patients The system aims to exploit the phenomenon of RNA interference, where short sequences of double-stranded RNA, called small interfering RNA or siRNA, can trigger the disruption of the manufacture of certain proteins in a cell. |
Chemistry World August 7, 2008 Simon Hadlington |
RNA stops HIV in its tracks Scientists have successfully used a biochemical Trojan horse to smuggle killer sequences of RNA into immune cells to mug invading HIV, stopping infection in its tracks |
The Motley Fool February 9, 2006 Jason Mac Gurn |
RNA: Rule Breaker Nucleic Acid Investors, new RNA-based technologies may be the next revolution in biopharmaceuticals. ISIS Pharmaceuticals... Sirna Therapeutics... Alnylam Pharmaceuticals... |
The Motley Fool September 28, 2007 Brian Orelli |
RNAi Doesn't Kill Mice After All From Merck, to AstraZeneca, to Novartis, big pharma continues to pump hundreds of millions of dollars into unproven RNAi technology. Investors, take note. |
HHMI Bulletin Winter 2013 Sarah C.P. Williams |
Cellular Search Engine Craig Mello's lab has now uncovered the reason piRNA molecules are so ubiquitous and exist in so many forms in C. elegans: so they can pair with essentially any genetic sequence they encounter during their endless scanning. |
Chemistry World April 20, 2009 James Urquhart |
New method reveals small molecule-RNA conjugates US scientists using novel chemical screening methods have discovered a new class of small molecules connected to RNA, suggesting that cellular RNA may be more chemically diverse than previously thought. |
Chemistry World July 17, 2012 Simon Perks |
Synthetic nanozymes silence hepatitis C Researchers at the University of Florida, US, have discovered that an artificial nanoparticle complex, known as a nanozyme, can help to treat viral infections by 'shutting off' their genetic material. |
Bio-IT World July 15, 2003 Malorye Branca |
Silence Is Golden RNA interference's scientific, therapeutic, and economic potential is unquestionable, but some sticky questions still remain. |
Chemistry World August 31, 2011 Hayley Birch |
Smallpox vaccine virus puts cancer in its sights The results of a human cancer therapy trial show for the first time that tumors can be targeted and infected by engineered viruses, without damage to surrounding tissues. |
Chemistry World September 3, 2008 Hayley Birch |
Double emulsions could carry combination therapies US scientists have made nanoscale water-in-oil-in-water emulsions that could have important applications in drug delivery. |
Bio-IT World December 15, 2004 William Marshall |
Applications of RNAi RNA interference is a highly coordinated gene regulatory mechanism that appears to be highly conserved across all metazoans studied thus far. |
Bio-IT World December 15, 2004 Zachary Zimmerman |
Silence Is Golden Life Science Insights believes that RNAi therapeutics will dramatically affect the pharmaceutical and healthcare industries, becoming the next major class of therapeutics, joining small molecules, proteins, and monoclonal antibodies. |
Chemistry World May 13, 2009 Lewis Brindley |
Combination nanoparticles to fight cancer Korean chemists have assembled a multitalented nanoparticle that can hunt down, treat, and illuminate cancerous cells. |
Chemistry World February 12, 2014 Manisha Lalloo |
Synthetic strategy targets 'undruggable' small RNAs Chemists in the US have found a way to predict small molecules that can target short pieces of RNA involved in some diseases, such as cancer. |
Chemistry World September 18, 2006 Michael Gross |
Iron Chelates Beat Cancer Cancer cells need more iron than normal body cells to sustain their abnormally rapid growth. Researchers have now identified one particularly potent chelate complex that helps deplete tumors of iron. |
Chemistry World November 27, 2007 James Mitchell Crow |
A Flare for Gene Silencing US scientists have developed nanoparticle probes coated with DNA that release fluorescent 'flares' when they silence genes inside cells. |
Chemistry World January 13, 2010 Simon Hadlington |
Click chemistry reveals sugar synthesis in live animals US researchers have used 'click chemistry' to attach chemical tags to complex sugar molecules in the cells of live mice, allowing the synthesis of the sugars - glycans - within the cells to be tracked. |
The Motley Fool July 11, 2007 Brian Orelli |
Everybody Loves RNAi Roche is the latest firm to (over)pay for the hottest new drug technology. Alnylam announced that it licensed some of its intellectual property to Roche for $331 million. Investors, take note. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
HHMI Bulletin Aug 2011 Cassandra Willyard |
A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice. |
Chemistry World September 26, 2006 Fiona Case |
Synchronised Delivery for DNA and Drugs Polymer capsules that can simultaneously deliver drug molecules and DNA into a cell could boost the power of cancer treatments. |
Bio-IT World December 15, 2004 Nancy Weil |
Running Interference The revolution in RNA interference has galvanized basic research. Now, some biopharmas are pushing the technology from the laboratory to the clinic. |
Chemistry World June 21, 2011 Carol Stanier |
Nanotubes Inject Stroke Therapy Into Rats' Brains Carbon nanotubes act as a delivery vehicle for small pieces of RNA that help to prevent cell death in the brain after stroke. |
HHMI Bulletin February 2011 Sarah C.P. Williams |
Skin Sense An early question about aging skin led to answers on how cells code for their location. |
Chemistry World October 5, 2014 Andy Extance |
Tea tonic peps up tumor treatment Researchers in Singapore and the US have brewed up a green tea-based cancer drug delivery system where both the drug and its carrier fight tumor growth. |
Technology Research News September 22, 2004 |
Virus Forms Nano Template Living matter self-assembles into complex organisms that can contain billions of cells, and researchers have tapped biological molecules like DNA and viruses to self-assemble technologically useful structures and materials. |
Chemistry World September 1, 2011 Elinor Richards |
Vitamin scaffold turns silent killer into a healing hero A way to deliver carbon monoxide into the body safely for therapeutic use has been devised by scientists from Switzerland. |
Bio-IT World November 2005 Robert M. Frederickson |
Innovations in Interference RNAi has moved from phenomenon to promising drug in less than five years, but it also has potential to be a tool used in drug discovery. |
Chemistry World July 28, 2009 Michael Gross |
DNA to direct and switch off chemo Researchers in the US have developed a new approach to cancer chemotherapy using short DNA strands to help target delivery of the drug directly to cancer cells, and 'call it off' should problems arise. |
Chemistry World March 16, 2009 Hayley Birch |
Nanodumbbells Target Cancer Cells US scientists have designed nanoparticles that function like 'guided missiles' in the targeted destruction of breast cancer cells. |
Scientific American June 2005 JR Minkel |
RNA to the Rescue The spectacular discovery that a species of plant can summon up genes its parents have lost highlights biologists' increasing recognition of RNA as a more versatile and important molecule in its own right. |
Technology Research News March 12, 2003 |
RNA forms nanomotor Researchers from Purdue University have constructed a tiny motor from DNA and RNA molecules. The device, fueled by ATP, which powers our own movements, could eventually power nanomachines. |
Chemistry World May 22, 2009 Phillip Broadwith |
'Printing' organs with hydrogels Dutch researchers have developed a way to 'print' stable cell-containing scaffolds, creating a method that could one day be used to help make tailor-made tissue grafts |
Chemistry World May 1, 2008 Simon Hadlington |
Click chemistry illuminates embryo development US researchers have smuggled modified sugar molecules into a developing zebrafish embryo and then used 'click chemistry' to snap a fluorescent tag onto them to watch cells and tissues forming. |
Chemistry World September 5, 2013 Emma Stoye |
Raman-based imaging takes guesswork out of brain surgery A new technique that color-codes cancerous and healthy brain cells according to their chemistry could help surgeons remove all traces of brain tumors while minimizing damage to sensitive tissues. |
Chemistry World April 10, 2008 Sarah Houlton |
Radiotherapy Side-Effects Suppressed A new drug being developed by scientists at Cleveland BioLabs (CBLI) in the US may hold the key to protecting healthy cells from the effects of radiotherapy during cancer treatment. |
Technology Research News May 5, 2004 Kimberly Patch |
DNA Bot Targets Cancer Researchers from Israel have constructed a molecular-size computer that is programmed to find signs of cancer cells, and when they are present, dispense DNA molecules designed to eradicate those cells. |
Chemistry World October 2, 2006 Bea Perks |
RNAi Pioneers Win Nobel Prize for Medicine Molecular biologists Andrew Fire and Craig Mello have been awarded this year's Nobel prize in physiology or medicine for their discovery of RNA interference. |
Chemistry World June 4, 2008 John Bonner |
Fireflies make light work of tumours Cancer researchers can see how effective new chemotherapy drugs are at destroying tumours by using the light that causes fireflies to glow in the dark. |
Scientific American September 19, 2005 Charles Q. Choi |
Chatting Up Cells Stem cells can transform into whatever cell the body tells them to. Unfortunately, scientists have yet to master that particular gift of gab. But investigators may soon crack the language with tiny "chat rooms" for stem cells. |
Chemistry World February 19, 2009 Nina Notman |
Nanoparticles give cancer drug a boost US scientists have taken a novel step towards fighting the reoccurrence of lung cancer, using drug delivering nanoparticles. |
Chemistry World November 12, 2009 Hayley Birch |
New drug design looks top Notch against cancer A new type of drug that can block the switching on of certain genes in cancer cells has shown promise in mice. |
Technology Research News January 12, 2005 |
RNA Tiles Form Nanopatterns Researchers have developed a method of coaxing artificial RNA molecules to self-assemble into specific shapes, much like a jigsaw puzzle automatically assembling. The structures could eventually be used as templates for nanochips, nanocircuits and nanocrystals |
Chemistry World January 20, 2011 Erica Wise |
Protective shells for cells A highly permeable shell made for living cells could substantially extend their lifetime in bioengineering applications, including aiding bone repair, say US scientists. |
Chemistry World April 2010 |
Column: The crucible We are getting better at manipulating cells to grow into the tissues we need. Chemical factors are key, says Philip Ball |